Fomitopsis officinalis mushroom: ancient gold mine of functional components and biological activities for modern medicine

Elkhateeb, Waill A; Daba, Ghoson M.; Elnahas, Marwa O.; Thomas, Paul W.

doi:10.4103/epj.epj_46_19

Cited by 12 publications

(5 citation statements)

References 34 publications

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“…The Agarikon mushroom, Fomitopsis officinalis, has been used in countries around the world for thousands of years; its wide range of benefits are still being researched and are yet to be fully developed (Stamets 2005 ). The studies that have been done so far have reported Agarikon as having antibacterial, anticancer, antiviral, anti-inflammatory, and antituberculosis activities (Elkhateeb et al 2019 ; Girometta 2019 ). Unfortunately, this particular mushroom grows very slowly and is increasingly difficult to find which has encouraged its cultivation in the boreal forests (Elkhateeb 2020 ).…”

Section: Medicinal Powerhousesmentioning

confidence: 99%

Old growth forests and large old trees as critical organisms connecting ecosystems and human health. A review

et al. 2022

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Old forests containing ancient trees are essential ecosystems for life on earth. Mechanisms that happen both deep in the root systems and in the highest canopies ensure the viability of our planet. Old forests fix large quantities of atmospheric CO2, produce oxygen, create micro-climates and irreplaceable habitats, in sharp contrast to young forests and monoculture forests. The current intense logging activities induce rapid, adverse effects on our ecosystems and climate. Here we review large old trees with a focus on ecosystem preservation, climate issues, and therapeutic potential. We found that old forests continue to sequester carbon and fix nitrogen. Old trees control below-ground conditions that are essential for tree regeneration. Old forests create micro-climates that slow global warming and are irreplaceable habitats for many endangered species. Old trees produce phytochemicals with many biomedical properties. Old trees also host particular fungi with untapped medicinal potential, including the Agarikon, Fomitopsis officinalis, which is currently being tested against the coronavirus disease 2019 (COVID-19). Large old trees are an important part of our combined cultural heritage, providing people with aesthetic, symbolic, religious, and historical cues. Bringing their numerous environmental, oceanic, ecological, therapeutic, and socio-cultural benefits to the fore, and learning to appreciate old trees in a holistic manner could contribute to halting the worldwide decline of old-growth forests.

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Section: Medicinal Powerhousesmentioning

confidence: 99%

Old growth forests and large old trees as critical organisms connecting ecosystems and human health. A review

et al. 2022

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“…Спектр виявленої фармакологічної активності трутовика лікарського дуже широкий. Численними дослідженнями доведено, що F. officinalis можна використовувати як джерело антибактеріальних, протигрибкових, протизапальних, протипухлинних, противірусних та імуностимулювальних засобів [22][23][24][25][26][27].…”

Section: вступunclassified

Screening of Strains of the Medicinal Mushroom Fomitopsis officinalis (vill.) Bondartsev & Singer Promising for Biotechnological Use

Mykchaylova

Poyedinok

Shchetinin³

2023

Innov Biosyst Bioeng

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Background. Macromycete cultivation methods development will contribute to the production of biotechnological products based on fungus. Determination of the main factors affecting medicinal macromycetes’ life processes allows to control biosynthetic activity of a fungal organism and obtain biotechnological products based on it. Objective. Screening of Fomitopsis officinalis strains promising for biotechnological use, and determining of physico-chemical factors that affect the cultures life processes. Methods. The objects of the study were three pure cultures of F. officinalis (IBK-2497, IBK-2498, IBK-5004). The influence of the acidity of the environment on the growth of mycelium, the needs of the cultures in the sources of carbon and nitrogen nutrition were determined. The following carbon sources were used: monosaccharides (glucose, xylose), disaccharides (sucrose, lactose) and trisaccharides (raffinose), polysaccharides (starch); nitrogen sources: KNO3, (NH4)2HPO4, asparagine, peptone. Dynamics of the culture growth were determined under the conditions of deep cultivation, on a liquid nutrient medium of glucose-peptone-yeast extract (GPA), g/l: glucose – 30.0; peptone – 3.5; yeast extract – 2.0; KH2PO4 – 1.0; K2HPO4 – 1.0; MgSO4×7H2O – 0.25. Results. The pH range between 5.5 and 6.0 was the most favorable for active growth of all studied strains of F. officinalis. The best carbon sources for growth were glucose and starch; peptone and asparagine were the best source of nitrogen. Nutrient media with xylose, lactose and nitrate nitrogen were least suitable for growth. Analysis of the strains growth dynamics on the GPA medium showed that the largest mass of mycelium (up to 11.54 ± 0.2 g/l) was produced by culture F. officinalis IBK-5004 on the 10-th day of cultivation. Cultures F. officinalis IBK-2497, IBK-2498 grew slower, and the mycelial mass was 10.33 ± 0.2 and 9.68 ± 0.3 g/l on the 14-th day of cultivation. Conclusions. Based on the obtained data, the F. officinalis IBK-5004 strain was selected. It can be considered a promising mycelial mass producer based on the set of characteristics.

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“…In recent years, metabolomics has emerged as an important methodology to determine the temporal and spatial correlations between metabolic cues and associated phenotypes in mushroom species [ 12 ]. A large number of studies elucidated the gamut of important metabolites in F. officinalis for their organoleptic properties, flavor, and nutritional and functional aspects, particularly anticancer potential [ 13 , 14 ]. Although the majority of studies characterized the lanostane-type triterpenoids class of secondary metabolites from F. officinalis [ 15 , 16 , 17 , 18 ], the spatial distribution of primary and secondary metabolomes in different mushroom parts is largely unknown with respect to the associated phenotypes.…”

Section: Introductionmentioning

confidence: 99%

Fomitopsis officinalis: Spatial (Pileus and Hymenophore) Metabolomic Variations Affect Functional Components and Biological Activities

et al. 2023

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Fomitopsis officinalis is a holartic polyporous mushroom that forms large fruiting bodies on old standing trees, fallen logs, or stumps. F. officinalis is a medicinal mushroom species that is most commonly used in traditional European medicine. In this study, we explore the spatial metabolic differences in F. officinalis’ mushroom parts, i.e., the cap (median and apical parts) and the hymenium. Additionally, chromatographic analysis was conducted in order to unravel the composition of specialized metabolites in the hydroalcoholic mushroom extracts. The potential antifungal and bacterial effects of extracts were tested against pathogen strains of Gram+ and Gram– bacteria, and yeast, dermatophytic, and fungal-pool species. Extracts from the apical part were the richest in terms of phenolic compounds; consistent with this finding, the extracts were also the most effective antiradical and antimicrobial agents with MIC values < 100 µg/mL for most of the tested bacterial and dermatophytic species. According to these findings, F. officinalis extracts are valuable sources of primary and secondary metabolites, thus suggesting potential applications in the formulation of food supplements with biological properties in terms of antioxidant and antimicrobial activities.

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Fomitopsis officinalis mushroom: ancient gold mine of functional components and biological activities for modern medicine

Cited by 12 publications

References 34 publications

Old growth forests and large old trees as critical organisms connecting ecosystems and human health. A review

Old growth forests and large old trees as critical organisms connecting ecosystems and human health. A review

Screening of Strains of the Medicinal Mushroom Fomitopsis officinalis (vill.) Bondartsev & Singer Promising for Biotechnological Use

Fomitopsis officinalis: Spatial (Pileus and Hymenophore) Metabolomic Variations Affect Functional Components and Biological Activities

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