Follow-up thallium-201 scintigraphy after mantle field radiotherapy for hodgkin's disease

Myocardial perfusion alterations observed months after radiotherapy are related to the cellular damage

“…The time interval required to observe cardiac perfusion defects is variable (6)(7)(8)11). Similarly, present studies do not have an agreement concerning the type of perfusion defects induced by radiotherapy (6)(7)(8)(9)11). Thus, the possible mechanism underlying the biodistribution alterations that give rise to the perfusion defects is not clearly verified.…”

“…Patients treated for Hodgkin's and non-Hodgkin's lymphoma and breast cancer have been the most extensively studied group (1)(2)(3)(4)(5)(6)(7)(8). The pathologic findings for RIHD are variable and classified by anatomic localization (2,9).…”

Expert consensus for multi-modality imaging evaluation of cardiovascular complications of radiotherapy in adults: a report from the European Association of Cardiovascular Imaging and the American Society of Echocardiography

“…In a recent study, the prevalence of stress-induced perfusion abnormalities increased from 5%, to 11%, and 20% in the 2-10 years, 11-20 years, and >20 years after irradiation, respectively. 109 In that study, myocardial ischaemia on SPECT was shown to be associated with a higher risk for subsequent coronary events, and prompted myocardial revascularization in a substantial proportion of patients. There are limited data comparing the accuracy of different imaging modalities to detect CAD in patients after mediastinal irradiation.…”

Cardiac Magnetic Resonance Imaging Findings in 20-year Survivors of Mediastinal Radiotherapy for Hodgkin's Disease

“…Gustavsson et al (12) described a clearly abnormal finding in 2 of 23 patients and an uneven isotope uptake of mottled type in 12 patients, leading to pathologic findings under treadmill exercise in 61% of their patients. An even higher prevalence of pathologic findings in a thallium-201 tomoscintigraphy at rest was reported by Pierga et al (27); 22 of 26 patients showed clearly abnormal findings 7 years after irradiation. The lastmentioned study used a procedure with a higher sensitivity to planar scintigraphy than was applied in the other studies.…”

“…In those patients, the median (range) time interval between the start of mediastinal radiotherapy and cardiac MRI was 24 (20)(21)(22)(23)(24)(25)(26)(27)(28) years. The median (range) age of the examined patients at the time of MRI was 45 (29-67) years.…”