Cardiac Magnetic Resonance Imaging Findings in 20-year Survivors of Mediastinal Radiotherapy for Hodgkin's Disease

Long-term Cardiovascular Toxicity in Children, Adolescents, and Young Adults Who Receive Cancer Therapy: Pathophysiology, Course, Monitoring, Management, Prevention, and Research Directions

“…Several small studies have evaluated the use of cardiac MRI in monitoring for early and late cardiotoxicity in children 251 and adults. [252][253][254] In 28 children during and immediately after chemotherapy, Oberholzer et al, 251 using cardiac MRI, found that end-systolic volume increased and that left and right ventricular ejection fraction decreased.…”

“…175 Furthermore, clinical evaluations may be misleading, because many patients are asymptomatic, 227 despite evidence from cardiac MRI studies of late myocardial enhancement that suggests that ≈30% of survivors have myocardial fibrosis or scarring and that ≈70% have perfusion deficits. 253 The diagnostic performance characteristics of noninvasive screening modalities, including stress echocardiography, ECG, and scintigraphy, to detect stress-induced ischemia are not as good as those of coronary angiography. 227 The sensitivity of new diagnostic tools, such as computed CT, magnetic resonance angiography, and coronary artery calcium scores, for detecting clinically important (>50%) stenosis as measured by angiography varies from 81% to 97% for men and from 76% to 98% for women, with specificity >77%.…”

2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines

“…Ponadto w ocenie morfologii zastawki mitralnej pomocna może być echokardiografia trójwymiarowa. U pacjentów z suboptymalną jakością obrazowania lub rozbieżnymi wynikami echokardiografii przydatny może być również CMR [309].…”

Cardiac Toxicity after Radiotherapy for Breast Cancer: Myths and Facts

“…The incidence of valvular disease is only related to mediastinal radiation doses > 30 Gy and younger age at irradiation, which was shown for survivors of Hodgkin's disease. After 20 years of follow-up, Machann et al [20] performed cardiac magnetic resonance imaging in 36 patients and revealed a hemodynamically relevant valvular dysfunction in 13 patients and a perfusion deficit in 21 patients.…”