Follow-up study of adults treated with roentgen rays for thyroid disease

Delawter, Dewitt S.; Winship, Theodore

doi:10.1002/1097-0142(196308)16:8<1028::aid-cncr2820160809>3.0.co;2-5

Cited by 35 publications

(8 citation statements)

References 12 publications

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“…Neither the time relationship between the development of each tumor nor the therapy for either tumor could be incriminated as etiologic factors for the second tumor. It is our belief that the higher No. 4 THYROID CARCINOMA MULTIPLEX * Wyse et aE.…”

Section: Discussionmentioning

confidence: 96%

Other malignant neoplasms associated with carcinoma of the thyroid: Thyroid carcinoma multiplex

Wyse

Hill

Ibañez

et al. 1969

Cancer

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All patients with thyroid carcinoma seen at The University of Texas M. D. Anderson Hospital and Tumor Institute at Houston between March 1944 and June 1968 were studied to determine the incidence of a second malignant tumor either before or after the diagnosis of thyroid cancer. Additionally, those patients having thyroid cancer as the initial cancer were studied to determine their risk of developing a second malignant tumor. Analysis of the latter was by the patient‐year method. Results showed that thyroid cancer patients have an increased number of second primary malignant tumors, and that they have a higher risk of developing a second primary after the diagnosis of thyroid cancer than the general population of the state of Connecticut. Possible explanations for these findings are discussed.

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Section: Discussionmentioning

confidence: 96%

Other malignant neoplasms associated with carcinoma of the thyroid: Thyroid carcinoma multiplex

Wyse

Hill

Ibañez

et al. 1969

Cancer

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“…There is no evidence one way or the other about whether thyroid cancer is more or less easily induced in hyperthyroid than in euthyroid people. DeLawter and Winship (1963) found no thyroid cancers in 222 individuals irradiated over 20 years of age, all with thyroid disease, two-thirds of them thyrotoxic at the time of irradiation, but the mean thyroid dose was 2 100 R.…”

Section: Therapeutic Irradiation In Adult Lifementioning

confidence: 98%

“…Without adequate information about tissue dose in individual patients and about the dose levels above which turnout yield may fall off in man, it may always be objected that the therapeutic doses were in fact above this level. They were certainly sometimes large enough to produce thyroid fibrosis in thyrotoxic people (DeLawter and Winship, 1963) or myxoedema in euthyroid people (Markson and Flatman, 1965 ;McHardy-Young, Lessor, Blackburn and O'Gorman, 1965). Thus the radiotherapeutic evidence to be cited about the relative radiosensitivity of different organs in the neck, even if consistent, should be regarded as suggestive but not by any means decisive.…”

Section: Therapeutic Irradiation In Adult Lifementioning

confidence: 99%

The relative sensitivity of different tissues to tumour induction by radiation: The human evidence

1969

Annals of the ICRP/ICRP Publication

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Introduction 83The most straightforward way to assess the 87 relative sensitivity of different tissues to the induction of tumours by radiation would be to 89 compare the induced tumour rates when all the 89 tissues received the same dose at the same time. 94 No assumption need then be made about the form of the close-response relation except that it 94 is the same in all tissues. The only close approach to this ideal situation in man is the exposure of the 95 foetus in antenatal radiography. In all the other 56 RADIOSENSITIVITY AND SPATIAL DISTRIBUTION OF DOSE 57 Circumstances in which large fractions of the body, and therefore many different organs, have been irradiated, therapeutically, accidentally, occupationally, or in war, the dose received by different organs has varied considerably, even when the organs have been "directly" irradiated. For example, it has been suggested that the dose in the stomach in an ankylosing spondylitic given X-ray therapy was about one-tenth of the dose in the overlying spinal marrow (Dolphin and Eve, 1968). An allowance for the difference in dose has to be made if the observed tumour incidences in the different organs are to provide information about the relative sensitivity of these organs to tumour induction.The ICRP assumes a linear relation between dose and biological effect. This is certainly the simplest function and will be used in what follows. The effect of choosing a different form of dose-response is considered later.A linear relation between radiation dose and tumour induction has implications for the mechanism of carcinogenesis by radiation. It cannot be expected to hold when the dose is high enough to produce gross tissue damage. When a high proportion of tissue cells is killed, tumour yield may well be reduced and when healing is imperfect, or fibrosis is marked, tumour yield may be increased. Extrapolation from such situations is primafacie a highly unreliable guide to what might be expected at dose limit or emergency levels of exposure. Therefore, information about tumour induction following localized therapeutic irradiation for cancer has not been used in formulating our conclusions. Also excluded is all information about tumour induction by radioactive materials that are selectively concentrated in particular organs--such as the bone-seekers and the isotopes of iodine and phosphorus. The problems of estimating the ratio of dose in the concentrating tissue and in the adjacent tissues are formidable (cf. ICRP Publication 11, A Review of the Radiosensitivity of the Tissues in Bone, 1968).Particularly useful information is available from three categories of human subjects--British patients with ankylosing spondylitis irradiated as adults, Americans irradiated in infancy or childhood for a supposedly enlarged thymus or for a variety of childhood complaints, and Japanese of all ages when exposed to an atom bomb explosion. In each category there was a range of exposure levels, and an approximate dose-response can be ascertained for two kinds of malignant diseas...

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“…It would appear that the thyroid is more resistant to carcinoma in adult life. Reporting in 1963, DeLawter and Winship found no cases of malignancy of the thyroid in a 20‐year follow‐up study of 222 patients who had had irradiation to the neck after the age of 20 years …”

Section: Adverse Effects Of Conventional Superficial X‐ray Therapymentioning

confidence: 99%

Adverse Effects of Superficial X‐Ray Therapy and Recommendations for Safe Use in Benign Dermatoses

Rowell

1978

The Journal of Dermatologic Surgery and Oncology

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Follow-up study of adults treated with roentgen rays for thyroid disease

Cited by 35 publications

References 12 publications

Other malignant neoplasms associated with carcinoma of the thyroid: Thyroid carcinoma multiplex

Other malignant neoplasms associated with carcinoma of the thyroid: Thyroid carcinoma multiplex

The relative sensitivity of different tissues to tumour induction by radiation: The human evidence

Adverse Effects of Superficial X‐Ray Therapy and Recommendations for Safe Use in Benign Dermatoses

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