Follow‐up of the melanoma patient

Deschner, Benjamin W.; Wayne, Jeffrey D.

doi:10.1002/jso.25324

Cited by 14 publications

(11 citation statements)

References 53 publications

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“…The therapeutic potential of targeting sphingolipid metabolism in melanoma, a tumour for which a resolutive cure is still lacking and with a high risk of local or disseminated recurrence after surgical excision of the primary tumour [55], has been previously demonstrated [24,27,[56][57][58]. Notably, some studies showed the involvement of A-SMase in critical phases of melanoma development such as proliferation, migration, the ability to metastasise, and the response to chemotherapy [29][30][31][59][60][61][62][63].…”

Section: Discussionmentioning

confidence: 99%

Acid Sphingomyelinase Downregulation Enhances Mitochondrial Fusion and Promotes Oxidative Metabolism in a Mouse Model of Melanoma

Coazzoli

Napoli

Roux-Biejat

et al. 2020

Cells

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Melanoma is the most severe type of skin cancer. Its unique and heterogeneous metabolism, relying on both glycolysis and oxidative phosphorylation, allows it to adapt to disparate conditions. Mitochondrial function is strictly interconnected with mitochondrial dynamics and both are fundamental in tumour progression and metastasis. The malignant phenotype of melanoma is also regulated by the expression levels of the enzyme acid sphingomyelinase (A-SMase). By modulating at transcriptional level A-SMase in the melanoma cell line B16-F1 cells, we assessed the effect of enzyme downregulation on mitochondrial dynamics and function. Our results demonstrate that A-SMase influences mitochondrial morphology by affecting the expression of mitofusin 1 and OPA1. The enhanced expression of the two mitochondrial fusion proteins, observed when A-SMase is expressed at low levels, correlates with the increase of mitochondrial function via the stimulation of the genes PGC-1alpha and TFAM, two genes that preside over mitochondrial biogenesis. Thus, the reduction of A-SMase expression, observed in malignant melanomas, may determine their metastatic behaviour through the stimulation of mitochondrial fusion, activity and biogenesis, conferring a metabolic advantage to melanoma cells.

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Section: Discussionmentioning

confidence: 99%

Acid Sphingomyelinase Downregulation Enhances Mitochondrial Fusion and Promotes Oxidative Metabolism in a Mouse Model of Melanoma

Coazzoli

Napoli

Roux-Biejat

et al. 2020

Cells

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“…For cutaneous melanoma, guidelines for followups exist. They are stage-specific and recommend history and physical examination at least annually [10]. Self-examination and patient education are important cornerstones in the follow-up surveillance.…”

Section: Discussionmentioning

confidence: 99%

A rare case of recurrent primary anorectal melanoma emphasizing the importance of postoperative follow-ups

Šandera

Beer

et al. 2020

BMC Surg

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Background: Primary anorectal melanoma can be a rare differential diagnosis of anorectal mass. Due to the low case number reported in the literature, physicians are not aware of this aggressive disease. Although no consensus exists, wide local excision and abdominoperineal resection are considered the mainstay therapy. Case presentation: An 85-year-old female patient presented with fecal incontinence 5 years after local resection of a primary anorectal melanoma. In the rectoscopy, a tumor proximal to the dentate line was identified and later confirmed as a recurrent primary anorectal melanoma. There were no signs of locoregional or distant metastasis on the MRI and PET/CT. She underwent another wide local excision and regained fecal continence postoperatively. Conclusions: Primary anorectal melanoma should belong to the differential diagnosis of anorectal mass. If technically feasible, wide local excision represents a less invasive treatment than abdominoperineal resection, retaining the anal sphincter and patient's quality of life. Even though wide local excision has a higher recurrence rate than abdominoperineal resection, there is no difference in survival between the two procedures. This is only under the premise that patients are followed-up regularly after wide local excision so that recurrence can be spotted early on and locally excised.

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“…Additionally, comparison of the frequency of early relapses in patients referred for trial participation with patients referred for regular adjuvant treatment is of interest. Furthermore, there is a lack of evidence regarding the role of incorporating imaging techniques in the follow-up of stage III melanoma patients in the current therapeutic era 4. Therefore, prospective studies comparing various imaging techniques and intervals might be helpful to the development of consensus regarding the timing and frequency of imaging prior, during, and after adjuvant therapy.…”

Section: Futurementioning

confidence: 99%

ASO Author Reflections: Frequent Relapses Prior to the Start of Adjuvant Therapy in Stage IIIB/C Melanoma

et al. 2019

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Follow‐up of the melanoma patient

Cited by 14 publications

References 53 publications

Acid Sphingomyelinase Downregulation Enhances Mitochondrial Fusion and Promotes Oxidative Metabolism in a Mouse Model of Melanoma

Acid Sphingomyelinase Downregulation Enhances Mitochondrial Fusion and Promotes Oxidative Metabolism in a Mouse Model of Melanoma

A rare case of recurrent primary anorectal melanoma emphasizing the importance of postoperative follow-ups

ASO Author Reflections: Frequent Relapses Prior to the Start of Adjuvant Therapy in Stage IIIB/C Melanoma

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