ASO Author Reflections: Frequent Relapses Prior to the Start of Adjuvant Therapy in Stage IIIB/C Melanoma

Bloemendal, Martine; Willigen, Wouter W. van; Bol, Kalijn F.; Wilt, Johannes H. W. de

doi:10.1245/s10434-019-07665-5

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Neoadjuvant or Adjuvant Therapy: Which Is Better?1

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“…However, there are several issues with adjuvant therapy. A problem with adjuvant studies is that they are already skewed, given there is a > 15% screening failure rate prior to the start of adjuvant therapy due to relapse [ 45 ]. Adjuvant therapy can involve a high rate of relapse, with recurrence in over 40% of patients.…”

Section: Neoadjuvant or Adjuvant Therapy: Which Is Better?mentioning

confidence: 99%

The “Great Debate” at Melanoma Bridge 2020: December, 5th, 2020

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Atkins²,

Eggermont

et al. 2021

J Transl Med

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The Great Debate session at the 2020 Melanoma Bridge virtual congress (December 3rd–5th, Italy) featured counterpoint views from experts on five specific controversial issues in melanoma. The debates considered whether or not innate immunity is important in the response to cancer and immunotherapy, how useful are the revised American Joint Committee on Cancer (AJCC) classification for the staging of patients, the use of sentinel node biopsy for staging patients, the use of triplet combination of targeted therapy plus immunotherapy versus combined immunotherapy, and the respective benefits of neoadjuvant versus adjuvant therapy. As is usual with Bridge congresses, the debates were assigned by meeting Chairs and positions taken by experts during the debates may not have necessarily reflected their own personal opinion.

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Section: Neoadjuvant or Adjuvant Therapy: Which Is Better?mentioning

confidence: 99%