Follow-up of Nonarteritic Anterior Ischemic Optic Neuropathy with Optical Coherence Tomography

Contreras, Inés; Noval, Susana; Rebolleda, Gema; Muñoz‐Negrete, Francisco J.

doi:10.1016/j.ophtha.2007.05.042

Cited by 124 publications

(104 citation statements)

References 44 publications

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“…However, other studies have demonstrated a tendency of NAION to involve the superior quadrant of RNFL, particularly in those patients with inferior altitudinal loss [78,79]. In the acute phase, the thickness of the RNFL can be dramatically increased to nearly double the values seen in the unaffected fellow eye [78,79]. In one study of patients with NAION, arteritic anterior ischemic optic neuropathy (AAION) and open angle glaucoma, patients with open angle glaucoma had greater cup size and thinning of the neuroretinal rim than those with NAION and AAION.…”

Section: Non-arteritic Anterior Ischemic Optic Neuropathymentioning

confidence: 88%

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Optical Coherence Tomography (OCT): Imaging the Visual Pathway as a Model for Neurodegeneration

et al. 2011

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Summary: Axonal and neuronal degeneration are important features of multiple sclerosis (MS) and other neurologic disorders that affect the anterior visual pathway. Optical coherence tomography (OCT) is a non-invasive technique that allows imaging of the retinal nerve fiber layer (RNFL), a structure which is principally composed of ganglion cell axons that form the optic nerves, chiasm, and optic tracts. Since retinal axons are nonmyelinated until they penetrate the lamina cribrosa, the RNFL is an ideal structure (no other central nervous system tract has this unique arrangement) for visualizing the processes of neurodegeneration, neuroprotection and, potentially, even neuro-repair. OCT is capable of providing high-resolution reconstructions of retinal anatomy in a rapid and reproducible fashion and permits objective analysis of the RNFL (axons) as well as ganglion cells and other neurons in the macula. In a systematic OCT examination of multiple sclerosis (MS) patients, RNFL thickness and macular volumes are reduced when compared to disease-free controls.Conspicuously, these changes, which signify disorganization of retinal structural architecture, occur over time even in the absence of a history of acute demyelinating optic neuritis. RNFL axonal loss in MS is most severe in those eyes with a corresponding reduction in low-contrast letter acuity (a sensitive vision test involving the perception of gray letters on a white background) and in those patients who exhibit the greatest magnitude of brain atrophy, as measured by validated magnetic resonance imaging techniques. These unique structure-function correlations make the anterior visual pathway an ideal model for investigating the effects of standard and novel therapies that target axonal and neuronal degeneration. We provide an overview of the physics of OCT, its unique properties as a non-invasive imaging technique, and its potential applications toward understanding mechanisms of brain tissue injury in MS, other optic neuropathies, and neurologic disorders.

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Section: Non-arteritic Anterior Ischemic Optic Neuropathymentioning

confidence: 88%

“…One important characteristic of NAION is a small or absent cup in the fellow eye. In most OCT studies, NAION patients have smaller optic cups than controls [75][76][77][78][79]. The reduction in cup size appears to represent an anatomical risk factor for the development of NAION.…”

Section: Non-arteritic Anterior Ischemic Optic Neuropathymentioning

confidence: 99%

Optical Coherence Tomography (OCT): Imaging the Visual Pathway as a Model for Neurodegeneration

et al. 2011

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“…3,4,7 Contreras et al 3 showed that OCT could be used to diagnose optic disc oedema and monitor pRNFL loss over time and that pRNFL thickness decreased to values within normal limits at the 1.5-month visit. Papchenko et al 7 showed that both macular thickness and volume parameters are correlated with visual sensitivity, using Stratus OCT and Humphrey automated perimetry in NAION.…”

Section: Discussionmentioning

confidence: 99%

“…In these studies, RNFL and macular GCL losses correlated well with visual field (VF) losses in both magnitude and location. 3,4 Using spectral domain OCT, we report a patient with NAION who showed disagreement between the area of early optic disc oedema and macular ganglion cell loss.…”

Section: Inroductionmentioning

confidence: 99%

Lack of Correspondence between Early Optic Disc Oedema and Macular Ganglion Cell Loss in Non-arteritic Anterior Ischaemic Optic Neuropathy

Park

Heo

et al. 2014

Neuro-Ophthalmology

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A 73-year-old Asian male presented with a 2-week history of acute visual disturbance in his right eye. Visual acuity in his right eye was hand movement and fundus examination showed right optic disc oedema and splinter haemorrhages on the disc margin. Each time the patient visited our clinic, spectral domain optical coherence tomography (OCT) was performed. He was diagnosed to have non-arteritic anterior ischaemic optic neuropathy. Optical coherence tomography showed disagreement between the areas of early peripapillary retinal nerve fibre layer thickening and macular ganglion cell layer thickness reduction.

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“…Estudos prévios demonstraram a habilidade do OCT em detectar o dano neural de forma quantitativa e reprodutível em diversas afecções da via óptica anterior (2)(3)(4)(5) . Apesar da grande maioria dos estudos terem avaliado o dano neural através da análise da CFNR peridiscal, trabalhos recentes demonstraram que a medida da espessura macular também pode ser importante para estimar o dano neural (6)(7) , principalmente em afecções onde a análise correta da CFRN na região peridiscal possa estar prejudicada.…”

Section: Introductionunclassified

Detecção de perda neural localizada através da redução da espessura macular na tomografia de coerência óptica: relato de caso

Cunha

Vessani

Monteiro

2008

Arq. Bras. Oftalmol.

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Follow-up of Nonarteritic Anterior Ischemic Optic Neuropathy with Optical Coherence Tomography

Cited by 124 publications

References 44 publications

Optical Coherence Tomography (OCT): Imaging the Visual Pathway as a Model for Neurodegeneration

Optical Coherence Tomography (OCT): Imaging the Visual Pathway as a Model for Neurodegeneration

Lack of Correspondence between Early Optic Disc Oedema and Macular Ganglion Cell Loss in Non-arteritic Anterior Ischaemic Optic Neuropathy

Detecção de perda neural localizada através da redução da espessura macular na tomografia de coerência óptica: relato de caso

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