Detecção de perda neural localizada através da redução da espessura macular na tomografia de coerência óptica: relato de caso

Cunha, Leonardo Provetti; Vessani, Roberto Murad; Monteiro, Mário Luiz Ribeiro

doi:10.1590/s0004-27492008000500027

Cited by 5 publications

(4 citation statements)

References 10 publications

(21 reference statements)

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“…Both GCL and macular thickness measurements were thinner in migraine patients but the difference was not statistically significant. Reduction in macular thickness with accompanying peripapillary RNFL thinning was documented in a migraine patient [ 27 ]. Ekinci et all reported decreased GCL thickness measurements in migraine patients and thinning in GCL was significant in migraine patients with aura [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

Ocular pulse amplitude and retina nerve fiber layer thickness in migraine patients without aura

et al. 2016

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BackgroundTo evaluate the ocular pulse amplitude (OPA), the posterior pole asymmetry analysis (PPAA), the peripapillary retinal nerve fiber layer (RNFL) thickness, the ganglion cell layer (GCL) thickness, macular thickness and visual field testing in migraine patients without aura.MethodsIn this prospective, cross-sectional and comparative study 38 migraine patients and 44 age and sex matched controls were included. OPA was measured by dynamic contour tonometry (DCT), PPAA, RNFL, GCL and macular thickness were measured by Heidelberg Spectral Domain Optical Coherence Tomography (SD-OCT) and standard perimetry was performed using the Humphrey automated field analyzer.ResultsThe difference in OPA was not statistically significant between the two groups (p ≥ 0.05). In the PPAA there was no significant difference between two hemispheres in each eye (p ≥ 0.05). The RNFL thickness was significantly reduced in the temporal and nasal superior sectors in the migraine group (p ≤ 0.05). The GCL and macular thickness measurements were thinner in migraine patients but the difference between groups was not statistically significant (p ≥ 0.05). There was no correlation between RNFL, GCL, macular thickness measurements and OPA values. There was no significant difference in the mean deviation (MD) and pattern standard deviation (PSD) between the two groups (p ≥ 0.05).ConclusionsMigraine patients without aura have normal OPA values, no significant asymmetry of the posterior pole and decreased peripapillary RNFL thickness in the temporal and nasal superior sectors compared with controls. These findings suggest that there is sectorial RNFL thinning in migraine patients without aura and pulsative choroidal blood flow may not be affected during the chronic course of disease.

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Section: Discussionmentioning

confidence: 99%

Ocular pulse amplitude and retina nerve fiber layer thickness in migraine patients without aura

et al. 2016

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“…We found 35 studies examining specifically the RNFL in migraineurs and found that studies have inconsistently shown that migraineurs have thinner RNFL than controls ( Cunha et al, 2008 ; Costello, 2009 ; Gipponi et al, 2013 ; Sorkhabi et al, 2013 ; Ekinci et al, 2014 ; Demircan et al, 2015 ; Yülek et al, 2015 ; Acer et al, 2016 ; Demirci et al, 2016 ; Feng et al, 2016 ; Verroiopoulos et al, 2016 ; Ergiyit, 2017 ; Reggio et al, 2017 ; Tunç et al, 2017 ; Abdellatif and Fouad, 2018 ; Tak et al, 2018 ; Bing et al, 2019 ; Ulusoy et al, 2019 ; You et al, 2019 ; Sirakaya et al, 2020 ; Yener and Yılmaz, 2020 ; Altunisik and Oren, 2021 ; Kanar et al, 2021 ; Panicker et al, 2021 ; Temel et al, 2021 ; Yurtoğulları et al, 2021 ), generally ipsilateral to the usual side of headache ( Martinez et al, 2008 ; Gunes et al, 2016 ; Khosravi et al, 2018 ). Lin et al examined 26 studies and also found thinner mean RNFL in migraineurs than in controls, especially in the superior and inferior eye quadrants ( Lin et al, 2021 ).…”

Section: Retinamentioning

confidence: 99%

“…In one study, investigators found that aura migraineurs had right-eye macular hypoperfusion during the right aura but left hemicranial pain, resolving within a week after resolution of pain and aura ( González-Martín-Moro et al, 2023 ). Aura migraineurs had thinner maculae after 6 months post-attack ( Cunha et al, 2008 ). Interestingly, the macular deep capillary density may be lower in all regions but the fovea in aura migraineurs (possibly due to retinal ischemia) ( Liu et al, 2023 ).…”

Section: Retinamentioning

confidence: 99%

Using optical coherence tomography and optical coherence tomography angiography to delineate neurovascular homeostasis in migraine: a review

Chaliha,

Vaccarezza,

Charng

et al. 2024

Front. Neurosci.

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Migraine is one of the world’s most debilitating disorders, and it has recently been shown that changes in the retina can be a potential biomarker for the disease. These changes can be detected by optical coherence tomography (OCT), which measures retinal thickness, and optical coherence tomography angiography (OCTA), which measures vessel density. We searched the databases Google Scholar, ProQuest, Scopus, and Web of Science for studies in English using OCT and OCTA in migraineurs, using the search terms “optical coherence tomography,” “OCT,” “optical coherence tomography angiography,” “OCTA” and “migraine.” We found 73 primary studies, 11 reviews, and 8 meta-analyses pertaining to OCT and OCTA findings in migraineurs. They showed that migraineurs had reduced retinal thickness (via OCT), retinal vessel density, and greater foveal avascular zone area (via OCTA) than controls. OCTA changes reflect a perfusion compromise occurring in migraineurs as opposed to in healthy controls. OCT and OCTA deficits were worse in migraine-with-aura and chronic migraine than in migraine-without-aura and episodic migraine. Certain areas of the eye, such as the fovea, may be more vulnerable to these perfusion changes than other parts. Direct comparison between study findings is difficult because of the heterogeneity between the studies in terms of both methodology and analysis. Moreover, as almost all case–control studies were cross-sectional, more longitudinal cohort studies are needed to determine cause and effect between migraine pathophysiology and OCT/OCTA findings. Current evidence suggests both OCT and OCTA may serve as retinal markers for migraineurs, and further research in this field will hopefully enable us to better understand the vascular changes associated with migraine, perhaps also providing a new diagnostic and therapeutic biomarker.

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“…Média da espessura macular em CFNR ou baixa em relação ao sexo espessura macular podem ser consideradas como uma forma de avaliarmos a perda de células ganglionares em afecções da via óptica anterior (5)(6)(7)(8)(9)(10) . Alguns estudos demonstraram que a espessura macular medida pelo OCT em pacientes glaucomatosos é significativamente menor quando comparada a de indivíduos normais (5)(6) .…”

Section: Gráficounclassified

Análise da relação entre espessura macular e espessura da camada de fibras nervosas

Boucault¹,

Moura²,

Mitre³

et al. 2011

Rev. bras.oftalmol.

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Detecção de perda neural localizada através da redução da espessura macular na tomografia de coerência óptica: relato de caso

Cited by 5 publications

References 10 publications

Ocular pulse amplitude and retina nerve fiber layer thickness in migraine patients without aura

Ocular pulse amplitude and retina nerve fiber layer thickness in migraine patients without aura

Using optical coherence tomography and optical coherence tomography angiography to delineate neurovascular homeostasis in migraine: a review

Análise da relação entre espessura macular e espessura da camada de fibras nervosas

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