Follow-up of intracranial aneurysms in autosomal-dominant polycystic kidney disease

Gibbs, Gordon F.; Huston, John; Qian, Qi; Kubly, Vickie; Harris, Peter C.; Brown, Robert D.; Torres, Vicente E.

doi:10.1111/j.1523-1755.2004.00572.x

Cited by 94 publications

(44 citation statements)

References 14 publications

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“…The relative risk is increased for a ruptured aneurysm in the classic and vascular types of EDS (type I/II and IV) and autosomal dominant polycystic kidney disease (ADPKD1 and ADPKD2) (Watnick et al 1999;Nekrysh 2000;Hademenos et al 2001). IAs occur in about 8% of ADKPD patients (Gibbs et al 2004) and recur frequently in ADKPD patients with known aneurysms, particularly if there is a positive family history (Ruggieri et al 1994;Belz et al 2003).…”

Section: Associations With Other Disordersmentioning

confidence: 99%

The genetics of intracranial aneurysms

Krischek

Inoue

2006

J Hum Genet

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The rupture of an intracranial aneurysm (IA) leads to a subarachnoid hemorrhage, a sudden onset disease that can lead to severe disability and death. Several risk factors such as smoking, hypertension and excessive alcohol intake are associated with subarachnoid hemorrhage. IAs, ruptured or unruptured, can be treated either surgically via a craniotomy (through an opening in the skull) or endovascularly by placing coils through a catheter in the femoral artery. Even though the etiology of IA formation is mostly unknown, several studies support a certain role of genetic factors. In reports so far, genome-wide linkage studies suggest several susceptibility loci that may contain one or more predisposing genes. Studies of several candidate genes report association with IAs. To date, no single gene has been identified as responsible for IA formation or rupture. The identification of susceptible genes may lead to the understanding of the mechanism of formation and rupture and possibly lead to the development of a pharmacological therapy.

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Section: Associations With Other Disordersmentioning

confidence: 99%

The genetics of intracranial aneurysms

Krischek

Inoue

2006

J Hum Genet

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“…The prevalence of ICAs is 2.8% in general population and 5.8% in ADPKD (46). ICAs are more commonly (77%-84% of cases) found in the anterior circulation (47,48). ICAs cluster in a small number of ADPKD families, and a positive family history of ICA is the only established risk factor associated with ICA in ADPKD.…”

Section: Surgical Resectionmentioning

confidence: 99%

Renal Relevant Radiology

Rahbari-Oskoui¹,

Mittal²,

Mittal³

et al. 2014

Clinical Journal of the American Society of Nephrology

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SummaryAutosomal-dominant polycystic kidney disease is a systemic disorder and the most common hereditary renal disease, which is characterized by cyst growth, progressive renal enlargement, and development of renal failure. The cystic nature of autosomal dominant polycystic kidney disease and its renal and extrarenal complications (kidney stones, cyst hemorrhage, intracerebral aneurysm, liver cysts, cardiac valve abnormalities, etc.) give radiologic imaging studies a central role in the management of these patients. This article reviews the indications, comparative use, and limitation of various imaging modalities (ultrasonography, magnetic resonance imaging, computerized tomography scan, Positron emission tomography scan, and renal scintigraphy) for the diagnosis and management of complications in autosomal dominant polycystic kidney disease. Finally, this work provides evidence for the value of total kidney volume to predict disease progression in autosomal dominant polycystic kidney disease.

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“…Conservative management is recommended for aneurysms smaller than 7 mm in the anterior circulation. 16,17 Larger aneurysms are treated by coil embolisation or surgical clipping.…”

Section: Intracerebral Aneurysmsmentioning

confidence: 99%