Follow-Up of Boys with Unilateral Compensatory Testicular Hypertrophy

Effect of vitamin E on oxidative stress in the contralateral testis of neonatal and pubertal hemicastrated rats

“…Clinical data regarding the fertility of adults with CTH have shown that the quality of semen is poor, and that dysfunction of the testis is anticipated [2]. Similar results have been observed in studies conducted on the quality of semen in animals with CTH [3].…”

“…Despite increased testicular volume, CTH does not seem to improve the quality of semen [6]. Furthermore, studies conducted on animal models show that the quantity and motility of sperm are significantly reduced relative to non-CTH controls [2]. The biological mechanisms by which CTH induces spermatogenic dysfunction have not been fully elucidated.…”

“…In a study published in 1987, it was shown that CTH increased sperm count and improved semen quality [5]. However, earlier studies showed that experimental models of CTH had poor quality semen and, in some cases, testis dysfunction [1,2]. These results were in contrast to an existing hypothesis that CTH increases hormone production and spermatogenesis, compensating for a damaged testis during the critical periods of prepuberty and puberty.…”

“…Previous studies have shown that the unilateral castration of immature animals results in compensatory hypertrophy of the remaining testis [1,2,3,4,5,6]. CTH is the result of the increased size and number of germ cells, as well as increased size of Sertoli cells [3], and of oversecretion of gonadotropins [2,3,4,5,6]. In a study published in 1987, it was shown that CTH increased sperm count and improved semen quality [5].…”

Prepubertal serum inhibin B in cryptorchid infants and in monorchid boys with compensatory testicular hypertrophy

“…During our telephone interviews all of those patients currently report failure after attempting paternity, in accordance with the deficit of serum T levels and azoospermia or oligospermia shown in pubertal males with CTH by Laron et al (6). Therefore, it is reasonable to presume that CTH of one testis is not able to prevent testicular insufficiency in adulthood (6).…”