Folliculotropic mycosis fungoides: A case after one-year follow-up

Hung, Tzu-Ling; Yeung, Chi-Yung; Perng, Cherng‐Lih; Gao, Hong‐Wei; Chiang, Chien-Ping

doi:10.1016/j.dsi.2017.05.001

Cited by 3 publications

(7 citation statements)

References 21 publications

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“…On the other hand, folliculotropic MF was not associated with an increased risk of infectious events, even though this form of disease has a worse prognosis than the classic type of MF, and several S. aureus infections have been reported in patients treated for a folliculotropic MF . The small number of patients with folliculotropic MF in our cohort could explain the absence of statistical association.…”

Section: Discussionmentioning

confidence: 56%

Infectious events and associated risk factors in mycosis fungoides/Sézary syndrome: a retrospective cohort study

et al. 2018

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Opportunistic germs were rarely recorded, but their incidence was probably prevented by adequate prophylaxis (ongoing in 28% of patients). As in patients living with AIDS, pneumonias were frequent. On the other hand, bacterial cutaneous infections represent a specific pattern in patients with MF/SS. Patients with chronic organ failure, lymphocytopenia and SS should be considered as being at high risk for infectious events. Pneumococcal vaccination should be systematically recommended, and prophylaxis with co-trimoxazole and valaciclovir when the CD4 count is < 0·2 × 10 cells L .

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Section: Discussionmentioning

confidence: 56%

Infectious events and associated risk factors in mycosis fungoides/Sézary syndrome: a retrospective cohort study

et al. 2018

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“…The staining intensity was deep in 70.0% of MFgroup, while only in 6.7% of BCIDs-group with a statistically significant result (p = 0.001). According to these findings, TOX was found to be overexpressed in MF-lesions by Huang et al (14) and Yu et al (4) . The TOX is a diagnostic marker for MF, and it may serve as a pathogenic component in the course of the disease.…”

Section: Discussionmentioning

confidence: 87%

“…Inversely, a positive TOX-expression is noticed in 6 of 19 (31.6%) of BCID/NS samples, with a strong positive TOX-expression was detected in only 1 of 19 (5.3%) of BCID-samples. However, inferior specificity (75%) and superior sensitivity (90.3%) was noted by Hung et al (14) , as both worked on larger number of cases with different methodology at genetic level and lower cut-off value.…”

Section: Discussionmentioning

confidence: 94%

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Assessment of The Diagnostic Value of TOX Versus CD3 Immunohistochemical Markers in Detection of Early Mycosis Fungoides Cases

Gobran¹,

Embaby²,

Hafeez³

2021

The Egyptian Journal of Hospital Medicine

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“…The abnormal TOX-expression in MF was also consequently proved in the early and chronic dermatitis, but did not adequately show the more advanced disease of MF. For MF diagnosis and prediction, the TOX could be used (14) .…”

Section: Discussionmentioning

confidence: 99%

Mycosis Fungoides Diagnosis Using TOX Versus Old Panel Immunohistochemical Markers

Gobran¹,

Alabiad²,

Hafeez³

et al. 2021

The Egyptian Journal of Hospital Medicine

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Background: For primary cutaneous lymphoma, mycosis fungoides (MF) is the most prevalent form with skin-homing T cells plus clonal proliferation of CD4. In many CTCLs, thymocyte selection associated with the HMG-box (TOX) is an uncontrolled gene, together with MF in comparison with controls. Early mycosis fungoides is difficult to diagnose, and, its distinction from inflammatory diseases is sometimes impossible. Objective: In this study, we compared the TOX vs C7 and CD4 expression as an early mycosis fungoides diagnostic markers & to assess their ability to differentiate Mycosis fungoides from benign cutaneous inflammatory diseases (BCID). Materials and methods: 60 patients who had been previously diagnosed as MF (30 cases) and BCID (30 cases). All were evaluated histopathologically using H & E and immunohistochemically staining for TOX, CD7 & CD 4. Results: There was statistically significant difference between MF and BCID with increased TOX, CD7 & CD4 expression among MF than among BCID and ability of TOX to detect all true positive cases (100.0%) compared to 83.3% for CD4 and 13.3% for CD7. TOX had the highest sensitivity (100.0%) and accuracy (88.3%) followed by CD4 with sensitivity of 88.3% and accuracy of 66.7%, (P < 0.001). Conclusion: TOX had the highest sensitivity (100.0%) & accuracy (88.3%) followed by CD4 with sensitivity of 88.3% and accuracy of 66.7%. Our results suggest that TOX is a useful marker in diagnosis of MF & differentiating it from BCID.

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Folliculotropic mycosis fungoides: A case after one-year follow-up

Cited by 3 publications

References 21 publications

Infectious events and associated risk factors in mycosis fungoides/Sézary syndrome: a retrospective cohort study

Infectious events and associated risk factors in mycosis fungoides/Sézary syndrome: a retrospective cohort study

Assessment of The Diagnostic Value of TOX Versus CD3 Immunohistochemical Markers in Detection of Early Mycosis Fungoides Cases

Mycosis Fungoides Diagnosis Using TOX Versus Old Panel Immunohistochemical Markers

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