Folliculostatins, gonadotropins and a model for control of growth in the grey fleshfly, Neobellieria (Sarcophaga) bullata

Loof, Arnold De; Bylemans, D.; Schoofs, Liliane; Janssen, Ine; Spittaels, Kurt; Broeck, Jozef Vanden; Huybrechts, Roger; Borovsky, Dov; Hua, Yuejin; Koolman, Jan; Sower, Stacia A.

doi:10.1016/0965-1748(95)00005-g

Cited by 47 publications

(19 citation statements)

References 27 publications

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“…Since trypsin biosynthesis in the gut of N. bullata is not controlled by 20 OH-ecdysone , it is possible that captopril directly stimulates ecdysteroid production, with an increase in vitellogenin synthesis as a result. In addition, since Neb-TMOF has ecdysiostatic properties (Hua et al,1994a,b;De Loof et al, 1995), the most likely explanation for the increase in vitellogenin titers in the hemolymph due to captopril feeding, is that captopril increases ecdysteriod titers by inhibiting the breakdown of Neb-TMOF. So Neb-TMOF may have an effect on ecdysteroid biosynthesis whereas breakdown product(s) of Neb-TMOF may have biological activity on trypsin biosynthesis.…”

Section: Discussionmentioning

confidence: 96%

Captopril, a specific inhibitor of angiotensin converting enzyme, enhances both trypsin and vitellogenin titers in the grey fleshflyNeobellieria bullata

Vandingenen

Hens

Macours

et al. 2001

Arch Insect Biochem Physiol

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A strong and constitutive angiotensin converting enzyme- or ACE-like activity was demonstrated in the hemolymph of the adult grey fleshfly Neobellieria bullata. In a competition assay, the N. bullata trypsin modulating oostatic factor (Neb-TMOF) was confirmed to be an in vitro substrate for this circulating Neb-ACE. Oral uptake of captopril, a selective and specific inhibitor of ACE, resulted in a complete phenotypic knockout of circulating ACE activity. When compared with control animals, captopril-fed female flies showed an increase in the liver meal-induced trypsin peak in the midgut and elevated levels of protein meal-induced yolk polypeptides in the hemolymph. The latter effect was not due to a slower vitellogenin uptake by the ovaries, because oocyte growth was not affected by the captopril treatment. The apparent synergism between the demonstrated ACE functionality and the previously reported effects of the oostatic peptide Neb-TMOF are discussed in the context of our recent finding that Neb-TMOF represents a prime candidate for being the first known in vivo substrate for circulating insect ACE. Arch.

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Section: Discussionmentioning

confidence: 96%

Captopril, a specific inhibitor of angiotensin converting enzyme, enhances both trypsin and vitellogenin titers in the grey fleshflyNeobellieria bullata

Vandingenen

Hens

Macours

et al. 2001

Arch Insect Biochem Physiol

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“…Such a strong divergence in development between the basal and the next follicle was also noted in ovarioles of solitary bees (Martins and Serrão, 2004b), and in fact, this seems to be an ancestral feature which these bees share with dipterans. The latter also have polytrophic meroistic ovaries and in many species development of the penultimate follicle is hormonally blocked until the basal follicle is released (Bylemans et al, 1994;De Loof et al, 1995).…”

Section: Discussionmentioning

confidence: 99%

Ovariole structure and oogenesis in queens and workers of the stingless beeMelipona quadrifasciata(Hymenoptera: Apidae, Meliponini) kept under different social conditions

Tanaka¹,

Santana²,

Hartfelder³

2009

Apidologie

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-The high variability in the reproductive biology of stingless bees makes them very amenable for comparative studies with other eusocial bee taxa. We investigated the structural organization of the ovaries of Melipona quadrifasciata queens and workers kept under different social conditions by analyzing their general histology, mitotic activity, and microfilament organization. The overall dynamics of ovarian activity were similar in the two castes, and at emergence their ovarioles contained a previtellogenic follicle. Stingless bees and honey bees differ in the structural organization in the lower germarium, but they have in common synchronized mitotic activity and putative germ line stem cells in the terminal filament. Unlike honey bees, stingless bee workers lay trophic eggs in addition to reproductive eggs. The overall similarities in oogenesis between the two taxa suggest that the decision to form trophic eggs should only occur in the late stages of oogenesis.worker reproduction / follicle development / actin cytoskeleton / ovary histology

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“…The studies have shown that Neb-TMOF also inhibits the biosynthesis of ecdysone, the vitellogenin synthesis inducing hormone of insect larvae [3][4][5]. The peptide undergoes a fast enzymatic degradation in the haemolymph, whereas it is stable in the intestine [6].…”

Section: Introductionmentioning

confidence: 99%

Copper(II) complexes of Neobelliera Bullata Trypsin Modulating Oostatic Factor and its analogues

Kowalik-Jankowska

Biega

Kuczer

et al. 2008

Journal of Inorganic Biochemistry

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Folliculostatins, gonadotropins and a model for control of growth in the grey fleshfly, Neobellieria (Sarcophaga) bullata

Cited by 47 publications

References 27 publications

Captopril, a specific inhibitor of angiotensin converting enzyme, enhances both trypsin and vitellogenin titers in the grey fleshflyNeobellieria bullata

Captopril, a specific inhibitor of angiotensin converting enzyme, enhances both trypsin and vitellogenin titers in the grey fleshflyNeobellieria bullata

Ovariole structure and oogenesis in queens and workers of the stingless beeMelipona quadrifasciata(Hymenoptera: Apidae, Meliponini) kept under different social conditions

Copper(II) complexes of Neobelliera Bullata Trypsin Modulating Oostatic Factor and its analogues

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