Follicular spicules associated with <i>Propionibacterium acnes</i> with response to erythromycin

Chia, Hui Yi; Tey, Hong Liang; Lee, Joyce Siong See

doi:10.1111/j.1346-8138.2010.00979.x

Cited by 4 publications

(5 citation statements)

References 9 publications

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“…A subsequent report of cryoglobulins accumulation in follicular content obtained from a patient with multiple myeloma supports this finding [3]. Besides, there has been speculation that Merkel cell polyomavirus, Propionibacterium acne , and Demodex folliculorum are the causes of the disease [15, 19, 20, 21, 22, 23]. However, there is a lack of evidence to support that these microorganisms play a role in the disease pathogenesis.…”

Section: Discussionmentioning

confidence: 87%

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A Case Report of Idiopathic Follicular Hyperkeratotic Spicules and Literature Review

2019

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Follicular hyperkeratotic spicules is a rare skin disorder that is usually associated with multiple myeloma. The condition typically presents with tiny hyperkeratotic spicules in follicular distribution and predominantly on the face. To our knowledge, there has been one reported case of this condition without underlying disease. We herein report the second case of idiopathic follicular hyperkeratotic spicules in a 54-year-old Thai woman presenting with multiple follicular horn-like spicules on her face and neck.

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Section: Discussionmentioning

confidence: 87%

“…To our knowledge, our patient is the second reported case of idiopathic follicular hyperkeratotic spicules. Previously reported cases of this disorder are demonstrated in Table 1 and Table 2 [1, 2, 3, 5, 6, 7, 8, 9, 10, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23].…”

Section: Discussionmentioning

confidence: 99%

A Case Report of Idiopathic Follicular Hyperkeratotic Spicules and Literature Review

2019

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“…P. acnes has also been associated with hyperkeratotic follicular spicules on the neck that cultured positively for P. acnes had resolved treatment with oral erythromycin. [ 9 ]…”

Section: Discussionmentioning

confidence: 99%

Is Propionibacterium acnes associated with hair casts and alopecia?

2012

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We report a series of four patients who presented with complaints of diffuse non-scarring alopecia. They had similar clinical features of alopecia, hyperseborrhea, and distinct keratinaceous hair casts that encircled the hair shafts. Propionibacterium acnes was isolated from two of the patients’ scalp, and Gram-positive, Giemsa-positive bacteria were seen in the hair follicles in the scalp biopsy of one of the patients. The patients’ symptoms did not respond to standard treatment for seborrheic dermatitis, but responded to a course of systemic antibiotics targeting P. acnes. We propose a role for P. acnes colonization of the terminal hair follicles in the pathogenesis of hair casts, and possibly diffuse non-scarring alopecia. Possible mechanisms of pathogenesis are discussed with a literature review.

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“…Antibiotics are prescribed for acne patients because reduced P. acnes numbers correlate with clinical improvement of acne in patients. 2) Antibiotics like erythromycin and clindamycin in combination with azelaic acid are used to treat severe acne. 3) However, high-dose administration of antibiotics induces the development of multiple-drug resistance and adverse side effects.…”

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confidence: 99%

In Vitro Anti-Propionibacterium Activity by Curcumin Containing Vesicle System

Liu

Huang

2013

Chem. Pharm. Bull.

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Propionibacterium acnes acts a critical role in the development of inflammatory acne when it overgrows in pilosebaceous units. The spread of multiple drug resistance bacteria indicates a growing need for new antimicrobial agents. The objective of this study is to develop lipid vehicles to deliver curcumin and inhibit P. acnes in the skin. The inhibitory activities of the curcumin containing vehicles against P. acnes were studied by the bioluminescence assay. Curcumin accumulation patterns in neonate pig skin were studied using Franz diffusion cells and confocal laser scanning microscopy. The physicochemical properties of the curcumin containing vehicles including interfacial tension, size distribution and viscosity were analyzed. Significant curcumin accumulation (362±8 µg/g skin) was observed with the lipid vehicles developed herein. Curcumin (0.43 µg/mL) in the vehicles significantly inhibited the growth of P. acnes. Confocal laser scanning microscopy confirmed the formation of curcumin reservoir in the skin by the curcumin-loaded vehicles. Curcumin-loaded vehicles could efficiently accumulate in the skin and inhibit P. acnes in vitro. Our results highlight the potential of using vehicles containing lauric acid and curcumin as an alternative treatment for acne vulgaris.

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Follicular spicules associated with Propionibacterium acnes with response to erythromycin

Cited by 4 publications

References 9 publications

A Case Report of Idiopathic Follicular Hyperkeratotic Spicules and Literature Review

A Case Report of Idiopathic Follicular Hyperkeratotic Spicules and Literature Review

Is Propionibacterium acnes associated with hair casts and alopecia?

In Vitro Anti-Propionibacterium Activity by Curcumin Containing Vesicle System

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