2019
DOI: 10.1159/000503272
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A Case Report of Idiopathic Follicular Hyperkeratotic Spicules and Literature Review

Abstract: Follicular hyperkeratotic spicules is a rare skin disorder that is usually associated with multiple myeloma. The condition typically presents with tiny hyperkeratotic spicules in follicular distribution and predominantly on the face. To our knowledge, there has been one reported case of this condition without underlying disease. We herein report the second case of idiopathic follicular hyperkeratotic spicules in a 54-year-old Thai woman presenting with multiple follicular horn-like spicules on her face and nec… Show more

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Cited by 4 publications
(8 citation statements)
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“…In the literature, SFH is most commonly reported to develop on the chin and neck. 7 , 8 On the contrary, lichen spinulosus most commonly presents with patches of follicular papules with keratotic spines upon the trunk and extremities 9 just like our case. Since the clinical locations of our case were more compatible with typical lichen spinulosus than SFH, the final diagnosis was lichen spinulosus.…”
supporting
confidence: 48%
“…In the literature, SFH is most commonly reported to develop on the chin and neck. 7 , 8 On the contrary, lichen spinulosus most commonly presents with patches of follicular papules with keratotic spines upon the trunk and extremities 9 just like our case. Since the clinical locations of our case were more compatible with typical lichen spinulosus than SFH, the final diagnosis was lichen spinulosus.…”
supporting
confidence: 48%
“…13 28 Other known associations are Crohn's disease, hypovitaminosis A, chronic renal failure, human immunodeficiency virus infection, cryoglobulinemia, Sezary syndrome, and lymphoma. 13 14 28…”
Section: Discussionmentioning
confidence: 99%
“…Treatment of SFH with topical retinoids, fluocinolone acetonide gel, and 12% lactic acid cream has been tried in the past with little benefit. 14 28 Discontinuation of the causative drug or management of the underlying condition is considered the definitive treatment. 13 28 Among the 11 cases of sorafenib-induced SFH in literature, six patients showed complete clearance of the rash on discontinuing sorafenib, with recurrence seen in three patients on reinstitution of treatment.…”
Section: Discussionmentioning
confidence: 99%
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“…We also introduce a classification of GP on purpose that, hopefully, will lead to better characterization for this condition. Clinicians should consider follicular GP in the differential diagnosis of multiple filiform hyperkeratotic lesions, especially on the face or intertriginous area [25].…”
Section: Discussion/conclusionmentioning
confidence: 99%