Follicular Mucinosis and Hodgkin's Disease

Update on primary cicatricial alopecias

“…226 Malignant transformation can occur over months to years. 217,219 Hodgkin's lymphoma is the predominant malignancy observed in children and young adults 211,[214][215][216]244,245 and, in the context of alopecia mucinosa, has a poor prognosis. 211,216,244,245 Several other types of alopecia mucinosa-associated malignancies have been reported.…”

“…217,219 Hodgkin's lymphoma is the predominant malignancy observed in children and young adults 211,[214][215][216]244,245 and, in the context of alopecia mucinosa, has a poor prognosis. 211,216,244,245 Several other types of alopecia mucinosa-associated malignancies have been reported. 209,[246][247][248][249][250][251] Notably, with the exception of MF, alopecia mucinosa can present as a paraneoplastic phenomenon.…”

“…Multiple biopsies may be required before a definitive diagnosis can be made, 213,243 except in cases of paraneoplastic alopecia mucinosa. 216,244,245 Therapeutic management. Identification of malignancy-associated alopecia mucinosa requires malignancy-directed therapy.…”

Follicular Mucinosis

“…46,61,63,64 Besides mycosis fungoides and Sézary syndrome, Hodgkin disease has also been observed in association with FM in several patients. 8,44,[65][66][67] However, the association of Hodgkin disease with mycosis fungoides is well known, 68 and it might be that in at least some of these patients, cutaneous changes represented lesions of mycosis fungoides-associated FM. Indeed, most patients showed clinical presentations uncommon for idiopathic FM: One child described by Gibson et al 44 had a widespread skin eruption involving the upper and lower extremities as well as the face; the child described by Kim and Winkelmann 8 had multiple lesions on the arms and legs; the patient described by Stewart and Smoller 67 had lesions on both legs; and the one described by Ramon et al 65 had multiple lesions on the chest.…”

Alopecia Mucinosa: Report of a Case and Review

“…27 The diagnosis of the associated malignancy may precede, coincide, or be made after the diagnosis of alopecia mucinosa. Other associated malignancies that have been documented include Hodgkin's lymphoma, [28][29][30] chronic lymphocytic leukemia, 31,32 acute myelogenous leukemia, 33 chronic myelogenous leukemia, 17 leukemia cutis, 17 Grawitz tumor (clear cell renal carcinoma), 34 cutaneous B-cell lymphoma, 35 lymphosarcoma, 36 squamous cell carcinoma of the tongue, 37 and CD30+ cutaneous T-cell lymphoma (Ki 1 lymphoma). 38 No uniformly accepted criteria have been used to predict the progression of alopecia mucinosa in those cases that are accompanied by cutaneous T-cell lymphoma or another malignancy.…”