Follicular Mucinosis

Cerroni, Lorenzo; Fink‐Puches, Regina; Bäck, Barbara; Kerl, Helmut

doi:10.1001/archderm.138.2.182

Cited by 189 publications

(33 citation statements)

References 60 publications

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“…Histology has not proved to be reliable in accomplishing this distinction. [13] Boer et al . have presented conclusive proof that AM is but one expression of MF and it is a lymphoma from its inception.…”

Section: Discussionmentioning

confidence: 99%

Follicular mycosis fungoides - A report of four Indian cases

Rajalakshmi

Inchara

Antony

2009

Indian J Med Paediatr Oncol

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Background:Follicular Mycosis Fungoides (FMF) is an under-recognized disease in India. Its clinical mimics include Hansen’s disease and Sarcoidosis.Aims:To describe the clinical and pathological features of FMF.Materials and Methods:All cases of FMF between January and December 2007 were retrieved. Cases of conventional epidermotropic MF with a minor follicular component were excluded. Slides were reviewed by two observers. The following criteria were assessed: degree and density of folliculotropism of lymphocytes, location of folliculotropism (infundibular / isthmic / bulbar), follicular mucin, eosinophils, granulomas, and conventional epidermotropism. Each feature was assigned a semi-quantitative grade.Results:There were four cases of FMF, with an equal gender distribution and a mean age of 17.5 years. All lesions were on the face. They presented as: hypopigmented patches (2) and erythematous plaques (2). Alopecia was seen in two cases. The clinical diagnosis was Hansen’s disease in all four, with a differential of Alopecia mucinosa / Sarcoidosis in two cases.The histological features seen were: disproportionate folliculotropism, lymphocyte tagging with haloes, follicular mucin, and nucleomegaly / convolution in all four cases, prominent eosinophils (2), epithelioid granulomas (1), eccrine infiltration (4), parakeratosis at the follicular ostia (2), and sebaceotropism (1). The infiltrate was bulbar (4) and isthmic (2). The rest of the epidermis showed no hint of conventional MF.Conclusion:The preferential features for FMF were involvement of face, dominant folliculotropism, nuclear atypia and convolution, and follicular mucin. Presence of granulomas and eosinophils necessitated exclusion of infectious causes. The absence of findings of MF in the rest of the epidermis should not deter pathologists from rendering this diagnosis.

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Section: Discussionmentioning

confidence: 99%

Follicular mycosis fungoides - A report of four Indian cases

Rajalakshmi

Inchara

Antony

2009

Indian J Med Paediatr Oncol

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“…Benign diseases with an overexpression of mucins include mucocutaneous neuromas, [40] generalized sclerodermatous graft-vs.-host disease, [41] follicular mucinosis (both idiopathic and lymphoma associated types) [42] and morphea profunda. [43]…”

Section: Mucin Expression In Benign Skin Disordersmentioning

confidence: 99%

Role of mucins in the skin during benign and malignant conditions

Chakraborty¹,

Bonthu²,

Swanson³

et al. 2011

Cancer Letters

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Skin related diseases comprise a major health challenge to the practicing physician, and constitute a significant psychological, social and financial burden to the society. Further, skin cancer, especially non-melanoma skin cancer is currently the leading type of malignancy in the Western world. Given the huge burden of skin diseases, there is growing emphasis on understanding their pathophysiology, and towards their early detection. Mucins are high molecular weight O- and N-linked glycoproteins that have emerged in recent years as important molecules in maintaining health and in promoting or protecting against inflammation and cancer. They have also begun to emerge as highly specific diagnostic and prognostic markers and novel therapeutic targets in several malignant disorders. However, their role in cutaneous pathologies has remained largely obscured. The present review provides the expression patterns and proposed role of mucins in the healthy skin and various benign and malignant skin diseases. The review has immense clinical significance as the availability of highly specific reagents including monoclonal antibodies against mucins makes them extremely attractive targets for specific diagnosis and/or immunotherapy of benign and malignant cutaneous diseases.

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“…39 Thus, we believe that idiopathic alopecia mucinosa may represent a variant of cutaneous T-cell lymphoma, requiring longterm followup to observe for the progression to the classic form of cutaneous T-cell lymphoma. 39 Likewise, investigators have tried to develop criteria to determine which cases of alopecia mucinosa would develop into cutaneous T-cell lymphoma, without success. 25,31,40 Others have tried to determine if a T-cell clonal expansion was synonymous with lymphoma in cases of alopecia mucinosa.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, it has been demonstrated that there are no clear-cut histological criteria to differentiate the idiopathic form of alopecia mucinosa from the lymphoma-associated form. 39 Dense lymphoid infiltrates with atypical-appearing lymphocytes can be seen in both idiopathic alopecia mucinosa and lymphoma-associated alopecia mucinosa. 39 Thus, we believe that idiopathic alopecia mucinosa may represent a variant of cutaneous T-cell lymphoma, requiring longterm followup to observe for the progression to the classic form of cutaneous T-cell lymphoma.…”

Section: Discussionmentioning

confidence: 99%

“…39 Dense lymphoid infiltrates with atypical-appearing lymphocytes can be seen in both idiopathic alopecia mucinosa and lymphoma-associated alopecia mucinosa. 39 Thus, we believe that idiopathic alopecia mucinosa may represent a variant of cutaneous T-cell lymphoma, requiring longterm followup to observe for the progression to the classic form of cutaneous T-cell lymphoma. 39 Likewise, investigators have tried to develop criteria to determine which cases of alopecia mucinosa would develop into cutaneous T-cell lymphoma, without success.…”

Section: Discussionmentioning

confidence: 99%

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