Follicular mucinosis: A detailed morphologic and immunopathologic study

Lancer, Harold A.; Bronstein, Ben R.; Nakagawa, Hidemi; Bhan, Atul K.; Mihm, Martín C.

doi:10.1016/s0190-9622(84)70091-0

Cited by 50 publications

(36 citation statements)

References 27 publications

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“…Similar dense lymphoid infiltrates have been reported in patients with idiopathic FM, which underscores the overlapping histopathologic features between the 2 groups. 1,6,22,47,61 The amount of mucin deposits within hair follicles and the presence of eosinophils within the infiltrate were similar in the 2 groups. It is also of interest to note that in 10 cases (35.7%) of lymphoma-associated FM, the diagnosis of CTCL was not made at presentation, and skin lesions were originally classified as idiopathic FM before analysis of sequential biopsy specimens proved the nature of the infiltrate.…”

Section: Commentmentioning

confidence: 86%

Follicular Mucinosis

Cerroni¹,

Fink‐Puches²,

Bäck³

et al. 2002

Arch Dermatol

189

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Context: Beginning in 1957, patients have been described with localized alopecia characterized histopathologically by mucin deposition within hair follicles (follicular mucinosis [FM]). At least 2 distinct diagnostic entities have been proposed: one occurring in children and young adults without association with other diseases ("idiopathic" FM), the other occurring in elderly patients and associated with mycosis fungoides or Sézary syndrome ("lymphoma-associated" FM).Objective: To determine whether idiopathic and lymphoma-associated FM are distinct or related entities.

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Section: Commentmentioning

confidence: 86%

Follicular Mucinosis

Cerroni¹,

Fink‐Puches²,

Bäck³

et al. 2002

Arch Dermatol

189

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“…Some feel the follicular keratinocytes [17][18][19] are the source, while others feel it is a complex interplay of many cell types. 20 A nonspecific inflammatory cell infiltrate, predominantly of lymphocytes, is seen in a follicular, perifollicular, and perivascular location. 21 Alopecia mucinosa has been shown to be associated with many benign and malignant conditions.…”

Section: Discussionmentioning

confidence: 99%

“…The mucin deposition is felt to be secondary to the interplay of T cells with the follicular keratinocytes. 20 A study showed a majority of the lymphocytes in alopecia mucinosa are of the T-helper-cell lineage. This coupled with the finding of increased Langerhans cells in alopecia mucinosa is the beginning evidence for a possible role for cell-mediated immunity in the pathogenesis of alopecia mucinosa.…”

Section: Discussionmentioning

confidence: 99%

“…This coupled with the finding of increased Langerhans cells in alopecia mucinosa is the beginning evidence for a possible role for cell-mediated immunity in the pathogenesis of alopecia mucinosa. 20 More studies to define the precise role of these inflammatory cells in the pathogenesis of follicular mucinosis are needed. The role of TNF-A and the determination of whether the helper lymphocytes that are present express a Th1 or Th2 profile are two questions that need to be better studied.…”

Section: Discussionmentioning

confidence: 99%

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Alopecia Mucinosa: Report of a Case and Review

Anderson

Mackley

Helm

2003

Journal of Cutaneous Medicine and Surgery: Incorporating Medica

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“…Unlike most other examples of epithelial mucin, the mucin in follicular mucinosis is acidic and is best identified by Alcian blue or colloidal iron staining. 19 The most common cause of follicular inflammation occurring on the face is, in fact, acne, but acne is rarely biopsied because it is readily identified clinically. In the setting of follicular inflammation, the histologic hallmark of acne is the dilation of the inflamed follicle by a plug of keratin and sebum, although that plug can become destroyed in intensely inflammatory lesions.…”

Section: Follicular Inflammationmentioning

confidence: 99%

Biopsies of Facial Dermatoses Made Simple

Al-Mohammedi

Crawford

Martinka

2014

Archives of Pathology &Amp; Laboratory Medicine

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Context.-Biopsy of the face is rarely done for inflammatory skin diseases, unless the entire process is confined to the face.Objective.-We hypothesized that facial dermatitis has a differential diagnosis that is more limited than the differential diagnosis of inflammatory skin diseases that affect other parts of the body. To our knowledge, the classification of inflammatory skin diseases occurring on the face has never been conducted before in the English literature.Design.-The most-recent 100 facial biopsies of inflammatory skin conditions were retrieved from our files, and the cases were categorized into the main inflammatory skin patterns.Results.-Forty-seven cases (47%) were categorized as interface dermatitis, 2 cases (2%) as psoriasiform dermatitis, 11 cases (11%) as spongiotic dermatitis, 16 cases (16%) as diffuse and nodular dermatitis, 8 cases (8%) as perivascular dermatitis, 14 cases (14%) as folliculitis and perifolliculitis, 1 case (1%) as panniculitis, and 1 case (1%) as fibrosing dermatitis. The number of diagnostic entities represented within each of these patterns was small.Conclusions.-We believe that facial dermatitis should have its own more-circumscribed differential diagnosis. From a practical viewpoint, many of the inflammatory skin diseases that affect other parts of the body should be excluded from the differential diagnosis after the tissue is determined to be from a facial skin biopsy, and others should not be considered unless the biopsy is from the face.(Arch Pathol Lab Med. 2014;138:550-552; doi: 10.5858/ arpa.2013-0055-OA) P hysicians and scientists interested in the skin have microscopically examined every visible abnormality on our exterior for more than a century, before surgical pathology emerged as a medical specialty and before endoscopic techniques facilitated histopathologic examination of other organ systems. This has resulted in a plethora of clinicopathologic correlation, and the result has been the clinicopathologic definition of literally hundreds of nonneoplastic skin conditions. Therefore, the critical task in assisting pathologists in practicing the dermatopathology of inflammatory skin conditions largely consists of prioritizing that wealth of information, rather than presenting recent discoveries.There is a particular opportunity for the distillation of information when biopsies of facial dermatoses are considered. Most patients affected by an inflammatory dermatosis do not have facial involvement, and sites other than the face are chosen for biopsy. Of those that do occur on the face, most occur synchronously elsewhere on the body. Patients and clinicians prefer that a site other than the face be biopsied whenever possible; therefore, facial biopsies usually come from dermatoses that are confined to the face at the time they present. Therefore, it was our hypothesis that, of the hundreds of inflammatory dermatoses, only a few would regularly appear in facial biopsies, and an analysis of the most recent 100 facial dermatoses submitted to our dermatopathology practi...

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Follicular mucinosis: A detailed morphologic and immunopathologic study

Cited by 50 publications

References 27 publications

Follicular Mucinosis

Follicular Mucinosis

Alopecia Mucinosa: Report of a Case and Review

Biopsies of Facial Dermatoses Made Simple

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