Follicular hyperkeratosis and cryocrystalglobulinemia syndrome. Occurrence in a patient with multiple myeloma

A Case Report of Idiopathic Follicular Hyperkeratotic Spicules and Literature Review

“…To our knowledge, our patient is the second reported case of idiopathic follicular hyperkeratotic spicules. Previously reported cases of this disorder are demonstrated in Table 1 and Table 2 [1, 2, 3, 5, 6, 7, 8, 9, 10, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23].…”

“…None of them showed effectiveness. However, improvement of the lesions in patients with multiple myeloma after receiving systemic chemotherapy has been reported [6, 12, 13, 16].…”

Cutaneous follicular hyperkeratotic spicules – the first clinical sign of multiple myeloma progression or relapse

“…Previous case reports did not describe the temporal relationship between the onset of cutaneous spicules with the disease activity of myeloma. There is, however, a strong suggestion of a close relation between both the hematologic disease and cutaneous manifestation, based on previous reports describing a resolution of the cutaneous lesions after treatment of the myeloma 3–5,19,20 …”

A case of bilateral renal arterial thrombosis associated with cryocrystalglobulinaemia

“…The true incidence of cryocrystalglobulinaemia is unknown. A review of the literature found ∼50 cases, but it is important to distinguish cryocrystalglobulinaemia and the other immunoglobulin crystalline nephropathies (crystal-storing histiocytosis, light chain Fanconi syndrome or light chain crystal deposition disease) which do not show crystal formation upon cooling [ 2–5 , 8 , 10 , 12–15 , 18–22 ]. In addition, the cutaneous and arthropathic features that are often found in cryocrystalglobulinaemia are absent in these entities.…”