Follicular Hybrid Cyst (Trichilemmal Cyst and Pilomatricoma) Arising Within a Nevus Sebaceus

Miyake, Hideaki; Hara, Hiroyuki; Shimojima, Hiroyuki; Suzuki, Hiroyuki

doi:10.1097/00000372-200410000-00008

Cited by 14 publications

(4 citation statements)

References 9 publications

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“…One author has hypothesized that pilomatrical differentiation within a hybrid cyst may be a feature of Gardner’s syndrome (12). A similar case to ours has been described (13)—an 11‐year‐old Japanese boy who developed a hybrid follicular cyst within a nevus sebaceous. This cyst displayed superficial trichilemmal differentiation and deep pilomatrical differentiation.…”

Section: Discussionsupporting

confidence: 80%

Hybrid Follicular Cyst (Pilomatrical and Infundibular) Arising Within a Sebaceous Nevus

Rodins

Baillie

2011

Pediatric Dermatology

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A 7-year-old girl presented with a 3-month history of a small blue-brown papule arising within a large sebaceous nevus on her temporal scalp. A punch excision was performed that demonstrated a hybrid follicular cyst. The majority of the cyst wall displayed pilomatrical differentiation consisting of basaloid matrical-type cells with luminal shadow cell keratinization. The matrical epithelium displayed strong membranous, cytoplasmic, and nuclear staining for β-catenin. Only a small component of the wall displayed infundibular differentiation. These findings were consistent with a hybrid follicular cyst predominantly displaying pilomatrical differentiation with only a small component of infundibular lining. The most common tumors arising within sebaceous nevi are the syringocystadenoma papilliferum and trichoblastoma. Follicular cysts with infundibular (sebaceous cyst) and trichilemmal (pilar cyst) differentiation are exceedingly common, although their development within sebaceous nevi appears to be rare. We report a rare case of a hybrid follicular cyst with matrical differentiation occurring within a sebaceous nevus.

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Section: Discussionsupporting

confidence: 80%

Hybrid Follicular Cyst (Pilomatrical and Infundibular) Arising Within a Sebaceous Nevus

Rodins

Baillie

2011

Pediatric Dermatology

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“…11,12 Furthermore, nevus trichilemmocysticus should be distinguished from cases of nevus sebaceus superimposed by a proliferating cyst that usually occurs as a solitary lesion. 22,23 Our patient had arthritis in her childhood and adolescence, severe osteomalacia with bone The origin of trichilemmal cyst nevus is unknown. Multiple nonsegmental trichilemmal cysts are inherited as an autosomal dominant trait, and the underlying gene TRICY1 has been mapped to chromosome 3p24-p21.2.…”

Section: Discussionmentioning

confidence: 94%

Trichilemmal cyst nevus: A new complex organoid epidermal nevus

Tantcheva‐Poór

Reinhold

Krieg

et al. 2007

Journal of the American Academy of Dermatology

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“…[ 5 ] Follicular hybrid cyst of trichilemmal cyst and pilomatricoma has been reported in one case. [ 17 ] Lichenoid interface dermatitis in the lining of epidermal cysts is uncommon. [ 18 ] We observed lichenoid tissue reaction in a follicular hybrid cyst, which has not been described before.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological Appraisal of Cutaneous Cysts: A 2-Year Retrospective Observational Study

Khullar,

Chandra

2023

Indian Dermatology Online Journal

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Background: Cysts, primarily epidermal and trichilemmal, are commonly seen in clinical practice. Rupture, infection, inflammation, and rarely malignant transformation may complicate the cysts. This study aims to analyze the clinicohistological features of cutaneous cysts. Materials and Methods: A retrospective review of patients with the diagnosis of cyst confirmed on histopathology over the past two years (2020–2021) was performed. Clinical details comprised of age, gender, site of involvement, size, duration, and associated symptoms. Histological examination included cyst wall lining, type of keratinization, complications like rupture, inflammation, foreign body giant cell reaction, calcification, and malignant change. Results: A total of 324 cases with mean age of 37.9 years and equal gender distribution were identified. Most frequent diagnosis was epidermal cyst in 89.8%, followed by trichilemmal cyst in 8.9% of cases. Rare types included follicular hybrid cyst, verrucous cyst, vellus hair cyst, and steatocystoma. Most common complication was cyst rupture in 54.3% of epidermal cysts. Proliferating epidermal and proliferating trichilemmal cysts were noted in one and two cases, respectively. Two cases revealed malignancy arising in the wall of epidermal cyst. Limitations: The retrospective study design and non-availability of follow-up data, especially for proliferating cysts and cysts with malignant transformation were the main limitations of this study. Conclusion: Histopathologic examination of excised cutaneous cysts is paramount in reaching accurate diagnosis of the type of cyst and associated secondary changes to enable appropriate management.

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Follicular Hybrid Cyst (Trichilemmal Cyst and Pilomatricoma) Arising Within a Nevus Sebaceus

Cited by 14 publications

References 9 publications

Hybrid Follicular Cyst (Pilomatrical and Infundibular) Arising Within a Sebaceous Nevus

Hybrid Follicular Cyst (Pilomatrical and Infundibular) Arising Within a Sebaceous Nevus

Trichilemmal cyst nevus: A new complex organoid epidermal nevus

Clinicopathological Appraisal of Cutaneous Cysts: A 2-Year Retrospective Observational Study

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