Follicular dendritic cell sarcoma of the spleen: A case report and review of the literature

Wang, Lifeng; Xu, Dongfeng; Qiao, Zhenguo; Shen, Li; Dai, Hongzhi; Ji, Yiding

doi:10.3892/ol.2016.4826

Cited by 19 publications

(16 citation statements)

References 20 publications

(14 reference statements)

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“…From 1996 to date we retrieved 22 publications reporting IPT-like FDC tumors [11,15,35,[89][90][91][92][93][94][95][96][97][98][99][100][101][102][103][104][105][106][107]. There were 46 patients described: 24 female, 22 male (ratio 1.1:1), median age 57y (range 29-79y).…”

Section: Follicular Dendritic Cell Tumors Of the Spleenmentioning

confidence: 99%

Inflammatory pseudotumor-like follicular dendritic cell tumor: an underdiagnosed neoplasia

et al. 2017

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Follicular dendritic cell (FDC) tumor is an uncommon neoplasm. It generally presents as a slow-growing, painless mass, without systemic symptoms. Histological features usually include low grade spindle cell proliferation. This tumor occurs primarily in lymph nodes, especially cervical and axillary, however, involvement of extranodal sites such as the tonsils, spleen, liver, and gastrointestinal tract has been reported. Inflammatory pseudotumor-like follicular dendritic cell tumor (IPT-like FDCT) is a rare, distinctive histological subtype of this low-grade malignant neoplasm, with consistent Epstein-Barr virus (EBV) association. The differential diagnosis with other fibro-inflammatory tumor proliferations, as inflammatory pseudotumor (IPT) and inflammatory myofibroblastic tumor (IMT), may be challenging. In the present article, two cases of IPT-like FDCT of the spleen are presented, with a broad overview of the literature: one 77-year-old male and one 70-year-old female. A large immunohistochemical panel should be used for diagnosis, as no single specific and totally sensitive markers are available, including markers for CD21, CD23, CD35, CNA42, and clusterin. Individual cases may express one or more of these markers, so that all of them should be investigated. In situ hybridization for EBV is constantly positive. Immunostaining for ALK should be negative, as it is present in roughly half of the cases of IMT. This panel should be used in combination of clinical, laboratory, and topographic evidences. Importantly, inclusion of this lesion as a possible option in clinical and pathological investigation represents the basis for a correct diagnosis.

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Section: Follicular Dendritic Cell Tumors Of the Spleenmentioning

confidence: 99%

Inflammatory pseudotumor-like follicular dendritic cell tumor: an underdiagnosed neoplasia

et al. 2017

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“…They may infiltrate adjacent parenchymal organs or soft tissues, and are almost always accompanied by abdominal pain. [ 5 , 11 ] Our patient presented with an isolated mass in the right chest wall without other remarkable features clinically or radiographically.…”

Section: Discussionmentioning

confidence: 86%

“…For example, tumors located in the superficial area of the neck often show small nodular or swollen growth and a general absence of hemorrhage and necrosis. [ 11 ] Tumors discovered in the abdomen tend to be deeper and larger, and are often accompanied by hemorrhage and necrosis. They may infiltrate adjacent parenchymal organs or soft tissues, and are almost always accompanied by abdominal pain.…”

Section: Discussionmentioning

confidence: 99%

Follicular dendritic cell sarcoma in the right chest wall

Xu¹,

Chen²,

Jiang

et al. 2020

Medicine

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Rationale: Follicular dendritic cell sarcoma (FDCS) is a rare malignant tumor that originates from germinal center follicular dendritic cells, and can occur at both nodal and extranodal sites. There are very few described cases of FDCS arising in the chest wall. Patient concerns: A 44-year-old male patient presented with a history of right chest wall pain for 5 months. Diagnoses: Positron emission tomography/computed tomography showed a significant increase in 18 F-fluorodeoxyglucose uptake and multiple small axillary lymph nodes without hypermetabolic lesions. Immunohistochemistry results of a core-needle biopsy indicated FDCS, which was consistent with the postoperative pathological examination. Interventions: The patient underwent tumor resection with lymphadenectomy of level I axillary nodes. No metastasis in the lymph nodes was observed in the postoperative pathological examination. The patient did not accept chemotherapy or radiotherapy. Outcomes: After 18 months, the patient remains in good condition with no evidence of disease recurrence. Lessons: This report highlights a rare case of a FDCS arising in the chest wall. Accurate clinical diagnosis and staging of this rare malignant sarcoma is essential for the developmnt of effective treatment strategies. Preoperative 18 F-fluorodeoxyglucose positron emission tomography/computed tomography scanning combined with core-needle biopsy could provide differentiation between benign and malignant tumors, as well as lymph node involvement and metastatic status.

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“…FDCs are located in primary and secondary follicles, trapping and presenting antigens to B cells, and storing immune complexes for long periods of time on the cell surface ( 58 , 59 ). The cause of FDCT remains unknown; potential risk factors may be Epstein Barr Virus (EBV) infection or Castleman disease ( 2 , 26 ), which may be found concurrently with FDCS or may precede the latter by several years ( 27 ). EBV is suspected to carry a viral oncogene-latent membrane protein 1 that may encourage transformation, often detected in the spleen and liver ( 30 , 34 ).…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological characteristics of extranodal follicular dendritic cell sarcoma: A report of two cases

2021

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Follicular dendritic cell sarcoma (FDCS) is an extremely rare tumor, which mainly originates from FDCs in the lymph nodes. Sometimes FDCS can arise from outside the lymph nodes due to the existence of acquired lymphoid tissue, which becomes the histological basis of the tumor. The diagnosis of FDCS, particularly extranodal FDCS, presents a challenge for pathologists and hematopathologists. The present study presents two cases of extranodal FDCS based on clinical features and histomorphology. Soft tissue of the chest wall was involved in case 1 and right tonsil tissue in case 2. Case 1 underwent surgery, and was in good health post-operatively. During the 5-month post-operative follow-up period, the patient was healthy in all respects. Case 2 received surgery combined with radiotherapy, and the follow-up data reported that the patient remained alive, without signs of recurrence or metastasis during the 4-month post-operative follow-up period. Additionally, a total of 102 cases of extranodal FDCS were retrieved from the literature, which were extracted and reviewed carefully. The rates of recurrence, metastasis and mortality were 14.63 (12/82), 17.07 (14/82) and 8.29% (15/82), respectively. The overall survival rates of the 102 cases, showing 2-year total survival rates, were 70%, the same with that of 5-year total survival rates. The 2-year tumor-free total survival rates were 68%, and the 5-year equivalents were 32%. Female patients had a poorer prognosis than male patients (P<0.05). Kaplan-Meier estimation presented no statistically significant differences between disease-free survival rates or overall survival rates and age, tumor size or treatment (P>0.05).

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Follicular dendritic cell sarcoma of the spleen: A case report and review of the literature

Cited by 19 publications

References 20 publications

Inflammatory pseudotumor-like follicular dendritic cell tumor: an underdiagnosed neoplasia

Inflammatory pseudotumor-like follicular dendritic cell tumor: an underdiagnosed neoplasia

Follicular dendritic cell sarcoma in the right chest wall

Clinicopathological characteristics of extranodal follicular dendritic cell sarcoma: A report of two cases

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