Follicle-stimulating hormone-mediated decline in miR-92a-3p expression in pubertal mice Sertoli cells is crucial for germ cell differentiation and fertility

Gupta, Alka; Vats, Amandeep; Ghosal, Anindita; Mandal, Kunal Kumar; Sarkar, Rajesh; Bhattacharya, Indrashis; Das, Soumya; Pal, Rahul; Majumdar, Subeer S.

doi:10.1007/s00018-022-04174-9

Cited by 13 publications

(10 citation statements)

References 102 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly, part of miRNA has been proven to be involved in spermatogenesis. For example, miR-92a is linked to the fertilizing potential of bovine sperm and is crucial for Sc-mediated induction of active spermatogenesis at puberty and regulation of male fertility ( 36 , 37 ). MiR-1306 was differently expressed in crossbred bull semen ( 38 ).…”

Section: Discussionmentioning

confidence: 99%

Comprehensive analysis of microRNA and metabolic profiles in bovine seminal plasma of different semen quality

et al. 2023

View full text Add to dashboard Cite

BackgroundSeminal plasma plays a pivotal role in modulating sperm viability and function. However, the underlying mechanisms have not been fully elucidated.MethodIn this study, the bull semen production records of core breeding farms and bull stations in the past 10 years were analyzed.ResultsWe found that the semen of 5-year-old bulls collected for the first time is of the best quality (p < 0.05). Despite the bull semen collected under the above conditions, low-quality sperm is still obtained from part of bulls due to individual differences. Interestingly, seminal plasma from normal semen is capable of improving low-quality semen motility. To identify the potential key factors in seminal plasma, the differences in miRNA and metabolite profiles between normal and low-quality seminal plasma were analyzed. We found that 59 miRNAs were differently expressed, including 38 up-regulated and 21 down-regulated miRNAs. Three hundred and ninety-one and 327 significantly different metabolites were identified from the positive and negative ion models, respectively. These multiple miRNAs and metabolites collectively contribute to the motility of sperm, subsequently, affect semen quality.DiscussionTogether, these results not only revealed the critical factors of seminal plasma improving sperm quality but also provided potential miRNA- or metabolite-based biomarkers to identify the high semen quality.

show abstract

Section: Discussionmentioning

confidence: 99%

Comprehensive analysis of microRNA and metabolic profiles in bovine seminal plasma of different semen quality

et al. 2023

View full text Add to dashboard Cite

show abstract

“…ncRNAs are RNA molecules, which are not translated into a protein, including transfer RNAs, ribosomal RNAs, small non-coding RNAs (snRNAs) and lncRNAs ( 44 ). snRNAs and lncRNAs regulate numerous biological functions and their expression is finely regulated at different stages of development of organisms to fulfill very particular functions ( 45 , 46 ). Numerous lines of evidence indicate their involvement in cancer, specifically in CC, and their differential expression, mainly in blood, has been related to diagnosis, prognosis, and treatment response of patients with CC, as described below.…”

Section: Ncrnasmentioning

confidence: 99%

Circulating cervical cancer biomarkers potentially useful in medical attention (Review)

Garrido

Gutiérrez²,

Flores

2023

Mol Clin Oncol

View full text Add to dashboard Cite

Cervical cancer (CC) is a public health problem worldwide, including Mexico. This type of cancer is the fourth most frequent in women worldwide; in Mexico it is the second most common type in women after breast cancer. The diagnosis of CC is based mainly on Pap smears and colposcopy and the identification of molecular tools that serve as a support for these methods is urgent. Regarding this, differential expressions of specific circulating biomolecules has been detected and, based on this, they have been postulated as potential biomarkers for CC diagnosis, prognosis, and/or to identify the response to treatments. Importantly, the combined analysis of these molecules considerably improves their efficacy as biomarkers and their potential use in the medical attention is promising. Contents1. Introduction 2. Proteins 3. ncRNAs 4. The estrogen effect on the expression of biomarkers 5. cDNA 6. Putative molecular mechanisms altered by the CC biomarkers 7. Circulating biomarkers expression in other HPV-related cancers 8. How feasible is it to use a test of this type in the heath sector of undeveloped countries? 9. The best biomarkers panel, according to our point of view 10. Conclusions and future directions

show abstract

“…Klf4 expression is induced via cAMP/PKA signaling pathway in the TM4 Sertoli cell line [ 87 , 88 ]. A recent in vivo study using mice demonstrates that FSH is able to induce expression of Klf4 via suppressing microRNA-92a-3p [ 141 ]. Nuclear factor (NF)-κB, a transcription factor that induces expression of genes related to SC function such as androgen binding protein, androgen receptor, is activated during SC differentiation following FSH stimulation in rats [ 89 ].…”

Section: Follicle-stimulating Hormone Signaling In Sertoli Cell Regul...mentioning

confidence: 99%

Follicle-stimulating hormone signaling in Sertoli cells: a licence to the early stages of spermatogenesis

Wang

Yang

et al. 2022

Reprod Biol Endocrinol

View full text Add to dashboard Cite

Follicle-stimulating hormone signaling is essential for the initiation and early stages of spermatogenesis. Follicle-stimulating hormone receptor is exclusively expressed in Sertoli cells. As the only type of somatic cell in the seminiferous tubule, Sertoli cells regulate spermatogenesis not only by controlling their own number and function but also through paracrine actions to nourish germ cells surrounded by Sertoli cells. After follicle-stimulating hormone binds to its receptor and activates the follicle-stimulating hormone signaling pathway, follicle-stimulating hormone signaling will establish a normal Sertoli cell number and promote their differentiation. Spermatogonia pool maintenance, spermatogonia differentiation and their entry into meiosis are also positively regulated by follicle-stimulating hormone signaling. In addition, follicle-stimulating hormone signaling regulates germ cell survival and limits their apoptosis. Our review summarizes the aforementioned functions of follicle-stimulating hormone signaling in Sertoli cells. We also describe the clinical potential of follicle-stimulating hormone treatment in male patients with infertility. Furthermore, our review may be helpful for developing better therapies for treating patients with dysfunctional follicle-stimulating hormone signaling in Sertoli cells.

show abstract

Follicle-stimulating hormone-mediated decline in miR-92a-3p expression in pubertal mice Sertoli cells is crucial for germ cell differentiation and fertility

Cited by 13 publications

References 102 publications

Comprehensive analysis of microRNA and metabolic profiles in bovine seminal plasma of different semen quality

Comprehensive analysis of microRNA and metabolic profiles in bovine seminal plasma of different semen quality

Circulating cervical cancer biomarkers potentially useful in medical attention (Review)

Follicle-stimulating hormone signaling in Sertoli cells: a licence to the early stages of spermatogenesis

Contact Info

Product

Resources

About