Folic acid perfusion administration reduced abdominal fat deposition in starter Arbor Acres broilers

Transcriptome Analysis of Effects of Folic Acid Supplement on Gene Expression in Liver of Broiler Chickens

“…On the other hand, our previous study has found that the folate-deficient food of broiler breeders remarkably increased the size of the lipid droplets and the expression of LPL and IGF2 genes in liver of offspring ( 20 ). Conversely, previous studies indicated that folic acid increased the expression of LPL and IGF2 genes and decreased the methylation level of IGF2 gene in liver of broilers ( 18 , 58 ). The differences in the LPL and IGF2 expression levels may be due to the different physiological stages of the chickens.…”

“…Until now, some studies are available regarding the effects of folic acid reducing lipid accumulation in 3T3-L1 adipocytes ( 56 ), chicken hepatocytes ( 17 , 57 ), and broilers ( 18 ). These results suggest that folic acid nutrients have the potential to regulate lipid metabolism.…”

“…Also, folic acid addition could reduce lipid deposition in primary chicken hepatocytes ( 17 ). Recently, Liu et al revealed that folic acid perfusion administration reduced abdominal fat deposition in broilers ( 18 ). On the other hand, it has been shown that the lipid and glucose metabolism of breeder cocks and broiler offspring were affected by paternal folic acid supplementation ( 19 ).…”

Effects of high-dose folic acid on protein metabolism in breast muscle and performance of broilers

“…Deposition of protein in muscle is a decisive process of gaining weight for animals ( Geiger et al, 2018 ). A previous study found that perfusion administration of 10 times the dose of folic acid to broiler chickens effectively reduced abdominal fat, but no change of body weight and feed conversion ratio were observed ( Liu et al, 2019 ). This might be due to the fact that perfusion was only administered for 11 d. Wang et al (2011) reported that appropriate amount of folic acid had potential to promote the protein synthesis in lactating sows.…”

“… Wang et al (2019) found that maternal folic acid supplementation enabled to affect metabolism of skeletal muscle protein by regulating relative genes of muscle growth and development in offspring lambs. In addition, our team previous study elucidated that perfusion of folic acid significantly reduced the weight and percentage of broiler abdominal fat, but no adverse effect was observed on body weight ( Liu et al, 2019 ). Hereby, we wondered if the high dose of folic acid enables to manipulate the protein deposition in broiler chest, and the potential regulatory mechanism also need to be further elucidated.…”