Effects of high-dose folic acid on protein metabolism in breast muscle and performance of broilers

Liang, Saisai; Liu, Xinshuai; Zhao, Jingyuan; Li, Rui; Huang, Xinhuo; Li, Yanli; Yang, Xiaojun; Yang, Xin

doi:10.1016/j.psj.2022.101935

Cited by 7 publications

(4 citation statements)

References 45 publications

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“…Currently, folic acid is widely used in animal husbandry due to various important physiological functions. For instance, folic acid administration in the basal diet significantly increase the serum immunoglobulin content, reduce the serum cholesterol and improve the apparent digestibility of dry matter, crude protein, and crude fat of chickens ( 67 , 68 ). Moreover, folic acid supplementation can also improve the growth performance of piglets ( 69 ).…”

Section: Discussionmentioning

confidence: 99%

Complete genome analysis of Bacillus subtilis derived from yaks and its probiotic characteristics

Wang

Lin

et al. 2023

Front. Vet. Sci.

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Probiotics have attracted attention due to their multiple health benefits to the host. Yaks inhabiting the Tibetan plateau exhibit excellent disease resistance and tolerance, which may be associated with their inner probiotics. Currently, research on probiotics mainly focuses on their positive effects on the host, but information regarding their genome remains unclear. To reveal the potential functional genes of Bacillus subtilis isolated from yaks, we sequenced its whole genome. Results indicated that the genomic length of Bacillus subtilis was 866,044,638 bp, with 4,429 coding genes. The genome of this bacteria was composed of one chromosome and one plasmid with lengths of 4,214,774 and 54,527 bp, respectively. Moreover, Bacillus subtilis contained 86 tRNAs, 27 rRNAs (9 16S_rRNA, 9 23S_rRNA, and 9 5S_rRNA), and 114 other ncRNA. KEGG annotation indicated that most genes in Bacillus subtilis were associated with biosynthesis of amino acids, carbon metabolism, purine metabolism, pyrimidine metabolism, and ABC transporters. GO annotation demonstrated that most genes in Bacillus subtilis were related to nucleic acid binding transcription factor activity, transporter activity, antioxidant activity, and biological adhesion. EggNOG uncovered that most genes in Bacillus subtilis were related to energy production and conversion, amino acid transport and metabolism, carbohydrate transport and metabolism. CAZy annotation found glycoside hydrolases (33.65%), glycosyl transferases (22.11%), polysaccharide lyases (3.84%), carbohydrate esterases (14.42%), auxiliary activities (3.36%), and carbohydrate-binding modules (22.59%). In conclusion, this study investigated the genome and genetic properties of Bacillus subtilis derived from yaks, which contributed to understanding the potential prebiotic mechanism of probiotics from the genetic perspective.

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Section: Discussionmentioning

confidence: 99%

Complete genome analysis of Bacillus subtilis derived from yaks and its probiotic characteristics

Wang

Lin

et al. 2023

Front. Vet. Sci.

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“…These findings suggested that protein in feed affects protein deposition in muscle. Studies have shown that activating the AKT/mammalian rapamycin (mTOR) pathway and increasing the phosphorylation activity of S6K1 can regulate protein deposition in muscle (Liang et al, 2022 ). Its protein complexes named mTOR C1 can then promote cell growth by inhibiting proteolytic metabolism, while amino acids stimulate the conversion of the regulator to an active nucleotide‐binding state, thereby allowing it to bind raptor and recruit mTOR C1 to the lysosomal surface (Saxton & Sabatini, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Exploring the effects of palm kernel meal feeding on the meat quality and rumen microorganisms of Qinghai Tibetan sheep

Raza

Gui

et al. 2023

Food Science & Nutrition

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Palm kernel meal (PKM) has been shown to be a high‐quality protein source in ruminant feeds. This study focused on the effects of feed, supplemented with different amounts of PKM (ZL‐0 as blank group, and ZL‐15, ZL‐18, and ZL‐21 as treatment group), on the quality and flavor profile of Tibetan sheep meat. Furthermore, the deposition of beneficial metabolites in Tibetan sheep and the composition of rumen microorganisms on underlying regulatory mechanisms of meat quality were studied based on ultra‐performance liquid chromatography coupled with quadrupole time‐of‐flight mass spectrometry as well as 16S rDNA sequencing. The results of the study showed that Tibetan sheep in the ZL‐18 group exhibited superior eating quality and flavor profile while depositing more protein and fat relative to the other groups. The ZL‐18 group also changed significantly in terms of the concentration and metabolic pathways of meat metabolites, as revealed by metabolomics. Metabolomics and correlation analyses finally showed that PKM feed mainly affected carbohydrate metabolism in muscle, which in turn affects meat pH, tenderness, and flavor. In addition, 18% of PKM increased the abundance of Christensenellaceae R‐7 group, Ruminococcaceae UCG‐013, Lachnospiraceae UCG‐002, and Family XIII AD3011 group in the rumen but decreased the abundance of Prevotella 1; the above bacteria groups regulate meat quality by regulating rumen metabolites (succinic acid, DL‐glutamic acid, etc.). Overall, the addition of PKM may improve the quality and flavor of the meat by affecting muscle metabolism and microorganisms in the rumen.

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“…Luo et al [27] highlight the benefits of higher vitamin supplementation for broilers exposed to coccidiosis under commercial conditions, in part, because of lower digestibility by diseased birds. In addition, folic acid at a level roughly 10-fold higher Vitamin Supplementation in Broiler Feeds and U.S. Survey on Fortification Rates DOI: http://dx.doi.org/10.5772/intechopen.112863 than average fortification rates in the U.S. increased gene expression for more muscle accretion in broilers [28]. On the other hand, more breast meat (P. major) accumulation occurred with 25-OH D 3 in ovo injections [29], which is consistent with an improved mitotic satellite cell formation and breast muscle yield in broilers fed 25-OH D 3 [30].…”

Section: Tablementioning

confidence: 99%

Vitamin Supplementation in Broiler Feeds and U.S. Survey on Fortification Rates

E. Ward

2024

Veterinary Medicine and Science

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This chapter covers a short review of the vitamin discovery period, followed by a discussion of the vitamins as nutritional supplements for poultry diets. These organic molecules perform within a complex metabolic system, and function in catalytic, developmental, and protective roles. Research in recent years suggests vitamins also play a pivotal role in the intestinal microbiome and “gut health” and may have direct effects on the establishment of a more desirable microbial population. Rapid changes in poultry genetics requires modifications in fortification rates, especially when less feed is required to attain these improvements. A survey on the vitamin fortification rates of broiler feeds in the U.S. is also included for discussion and comparison with a similar 1993 survey and the National Research Council. Some vitamins showed a wider disparity in fortification levels than others.

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Effects of high-dose folic acid on protein metabolism in breast muscle and performance of broilers

Cited by 7 publications

References 45 publications

Complete genome analysis of Bacillus subtilis derived from yaks and its probiotic characteristics

Complete genome analysis of Bacillus subtilis derived from yaks and its probiotic characteristics

Exploring the effects of palm kernel meal feeding on the meat quality and rumen microorganisms of Qinghai Tibetan sheep

Vitamin Supplementation in Broiler Feeds and U.S. Survey on Fortification Rates

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