Folic acid–PEO-labeled liposomes to improve gastrointestinal absorption of encapsulated agents

Anderson, Keith E.; Stevenson, Bruce R.; Rogers, James A.

doi:10.1016/s0168-3659(99)00072-3

Cited by 47 publications

(28 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MAL-PEG-PPSu spectrum includes the following peaks: the strong band at 1726 cm -1 assigned to the carbonyl groups of polyester and a broad band at 3500-3400 cm -1 corresponds to the hydroxyl groups of PEG conjugated to the polymer. Three small peaks that recorded at 1608, 1686 and a 606 cm -1 in FA-PEGPPSu copolymer indicated the conjugation of modified FA into PEG-PPSu since these two peaks existed only in the neat modified FA [26]. Evidence of the existence of hydrogen bonding between FA and PEG provides the shifting in lower wavenumber of band at 1608 cm -1 .…”

Section: Chemical Structure and Characterization Of Functional Materialsmentioning

confidence: 94%

Synthesis of folate- pegylated polyester nanoparticles encapsulating ixabepilone for targeting folate receptor overexpressing breast cancer cells

Sıafaka

Betsiou

Tsolou

et al. 2015

J Mater Sci: Mater Med

View full text Add to dashboard Cite

The aim of this study was the preparation of novel polyester nanoparticles based on folic acid (FA)-functionalized poly(ethylene glycol)-poly(propylene succinate) (PEG-PPSu) copolymer and loaded with the new anticancer drug ixabepilone (IXA). These nanoparticles may serve as a more selective (targeted) treatment of breast cancer tumors overexpressing the folate receptor. The synthesized materials were characterized by 1 H-NMR, FTIR, XRD and DSC. The nanoparticles were prepared by a double emulsification and solvent evaporation method and characterized with regard to their morphology by scanning electron microscopy, drug loading with HPLC-UV and size by dynamic light scattering. An average size of 195 nm and satisfactory drug loading efficiency (3.5 %) were observed. XRD data indicated that IXA was incorporated into nanoparticles in amorphous form. The nanoparticles exhibited sustained drug release properties in vitro. Based on in vitro cytotoxicity studies, the blank FA-PEG-PPSu nanoparticles were found to be non-toxic to the cells. Fluorescent nanoparticles were prepared by conjugating Rhodanine B to PEG-PPSu, and live cell, fluorescence, confocal microscopy was applied in order to demonstrate the ability of FA-PEG-PPSu nanoparticles to enter into human breast cancer cells expressing the folate receptor. Graphical Abstract 1 Introduction

show abstract

Section: Chemical Structure and Characterization Of Functional Materialsmentioning

confidence: 94%

Synthesis of folate- pegylated polyester nanoparticles encapsulating ixabepilone for targeting folate receptor overexpressing breast cancer cells

Sıafaka

Betsiou

Tsolou

et al. 2015

J Mater Sci: Mater Med

View full text Add to dashboard Cite

show abstract

“…As the PEO content decreased from 15.84% to 3.96 % (A 5 to A 10 ), there was a decrease in swelling index. It is 30.00 ± 5.23 A 5 27.75 ± 1.83 A 6 20.87 ± 3.43 A 7 19.20 ± 2.14 A 8 16.25 ± 4.09 A 9 14.00 ± 2.34 A 10 12.50 ± 2.42 A 11 13.56 ± 2.40 postulated that polymers having a higher cross-linking have more cross-link sites to constrain the polymer and therefore, the polymer does not ''open up'' easily. Such results have been reported by Ch'ng et al [31] Since crosslinking density of CP 934P is higher than PEO, [20] CP showed less swelling than PEO.…”

Section: Swelling Studiesmentioning

confidence: 99%

“…Polyethyene oxide has been successfully used in other drug delivery systems such as the geomatrix system, [2] pulsatile drug delivery, [3] osmotically controlled drug delivery, [4,5] solid dispersion, [6] micelles, [7] liposomes, [8] nanoparticles, [9] microparticles, [10] ophthalmics, [11] and injectables. [12] Polyethylene oxide possesses all the characteristics of an excellent mucoadhesive polymer, mucoadhesion capacity being greatly dependent on the average molecular weight.…”

Section: Introductionmentioning

confidence: 99%

Release of Diltiazem Hydrochloride from Hydrophilic Matrices of Polyethylene Oxide and Carbopol

Varma

Singla

Dhawan

2004

Drug Development and Industrial Pharmacy

View full text Add to dashboard Cite

The mucoadhesion, swelling, and drug release behavior of polyethylene oxide (PEO) and carbopol (CP) matrices were studied using a water soluble model drug diltiazem hydrochloride. The mucoadhesive strength of the matrices increased with increase in polymer content. The results showed that PEO was more mucoadhesive than CP. Mucoadhesion of the tablets was dependent upon the swelling. Swelling was ascertained by measuring the axial and radial expansion of matrix tablets following exposure to media of physiological ionic strength. There was a marked increase in the swelling index of matrices containing high polymer content of PEO as compared to CP. Drug release kinetics were found to be closely related to dissolution and swelling properties of the matrices. The release was found to be non-Fickian with n (release exponent) values ranging from 0.45-0.58. At a constant polymer content (15.84% w/w), the main contributing factor for the mucoadhesion, swelling, and release was the amount of PEO.

show abstract

“…[41] Consequently, in order to design the system with target specificity, FA is introduced into the nanocarriers which facilitated the delivery of them via receptor-mediated endocytosis. [42,43] Insulin can be loaded into the nanocarreris due to the hydrophoblic reactions between of insulin and VPBA. Because of the harsh conditions in GI tract, insulin as a kind of protein drugs is easily to be degraded.…”

Section: Characterization Of Nanocarriers and Composite Hydrogel Systmentioning

confidence: 99%

A composite hydrogel system containing glucose-responsive nanocarriers for oral delivery of insulin

Jiang

Yang

et al. 2016

Materials Science and Engineering: C

View full text Add to dashboard Cite

Folic acid–PEO-labeled liposomes to improve gastrointestinal absorption of encapsulated agents

Cited by 47 publications

References 21 publications

Synthesis of folate- pegylated polyester nanoparticles encapsulating ixabepilone for targeting folate receptor overexpressing breast cancer cells

Synthesis of folate- pegylated polyester nanoparticles encapsulating ixabepilone for targeting folate receptor overexpressing breast cancer cells

Release of Diltiazem Hydrochloride from Hydrophilic Matrices of Polyethylene Oxide and Carbopol

A composite hydrogel system containing glucose-responsive nanocarriers for oral delivery of insulin

Contact Info

Product

Resources

About