Folic acid conjugated capecitabine capped green synthesized fluorescent carbon dots as a targeted nano-delivery system for colorectal cancer

Paliwal, Shivangi; Jana, Pradip; Singh, Sneha; Madhyastha, Harishkumar; Webster, Thomas J.; Dev, Abhimanyu

doi:10.1016/j.mtcomm.2022.104590

Cited by 5 publications

(7 citation statements)

References 44 publications

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“…As a result, the currently in development CAP-FA-CNDP nanodelivery system presents a viable approach for efficient and targeted medication delivery in colorectal cancer. 169 In order to create dsRNA nanocomposites, Josemari ́a Delgado-Marti ́n et al obtained CNDs from glucose or saccharose as the nucleation source and passivated them with branched polyethylenimines. Hydrodynamic studies, transmission electron microscopy, X-ray photoelectron spectroscopy, and Fourier transform infrared spectroscopy were used to completely characterize the CDs.…”

Section: Resultsmentioning

confidence: 99%

“…Lastly, the apoptotic potential of the CAP-FA-CNDPs coupled system on HT-29 cells was demonstrated with clarity by flow cytometry analysis, where apoptotic cells rose to 77.2% and viable cells drastically fell to 21.4%. As a result, the currently in development CAP-FA-CNDP nanodelivery system presents a viable approach for efficient and targeted medication delivery in colorectal cancer …”

Section: Resultsmentioning

confidence: 99%

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Carbon Dots: Synthesis, Characterizations, and Recent Advancements in Biomedical, Optoelectronics, Sensing, and Catalysis Applications

Lamba,

Yukta,

Mondal

et al. 2024

ACS Appl. Bio Mater.

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Carbon nanodots (CNDs), a fascinating carbon-based nanomaterial (typical size 2−10 nm) owing to their superior optical properties, high biocompatibility, and cell penetrability, have tremendous applications in different interdisciplinary fields. Here, in this Review, we first explore the superiority of CNDs over other nanomaterials in the biomedical, optoelectronics, analytical sensing, and photocatalysis domains. Beginning with synthesis, characterization, and purification techniques, we even address fundamental questions surrounding CNDs such as emission origin and excitation-dependent behavior. Then we explore recent advancements in their applications, focusing on biological/biomedical uses like specific organelle bioimaging, drug/gene delivery, biosensing, and photothermal therapy. In optoelectronics, we cover CND-based solar cells, perovskite solar cells, and their role in LEDs and WLEDs. Analytical sensing applications include the detection of metals, hazardous chemicals, and proteins. In catalysis, we examine roles in photocatalysis, CO 2 reduction, water splitting, stereospecific synthesis, and pollutant degradation. With this Review, we intend to further spark interest in CNDs and CND-based composites by highlighting their many benefits across a wide range of applications.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Carbon Dots: Synthesis, Characterizations, and Recent Advancements in Biomedical, Optoelectronics, Sensing, and Catalysis Applications

Lamba,

Yukta,

Mondal

et al. 2024

ACS Appl. Bio Mater.

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“…In order to strengthen their stability, provide additional drug delivery capabilities, and lessen their intrinsic cytotoxicity, magnetic nanoparticles are often coated with polymers (Figure 4). Aside from covering magnetic nanoparticles with a substance to promote colloidal stability and biocompatibility, another question is avoiding further oxidation of the magnetic core, which would change its physical characteristics (Paliwal et al 2022). Magnetic nanoparticles are prospective drug delivery options for drug tracking using magnetic resonance imaging and therapeutic agent thermal administration.…”

Section: Microbiotamentioning

confidence: 99%

Cyclodextrin based nanoparticles for smart drug delivery in colorectal cancer

Marabada,

Li,

Wei

et al. 2023

Chem Biol Drug Des

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The advancement of colorectal cancer (CRC) prevention, detection, and treatment is essential to ensure that survivors live longer and higher‐quality lives. The field of cancer detection and therapy has undergone a revolution with the development of nanotechnology for targeted drug delivery. The significant problems with the delivery of cancer drugs are their solubility, stability, and nonspecific distribution. There is a challenge that the acidic and enzymatic environment in the digestive tract will modify or destroy the medication or the active pharmaceutical ingredient. To overcome the problems, nanoparticles have been widely employed during the past several years to increase the specificity, selectivity, and controlled release of drug delivery systems. The site‐specific and targeted delivery leads to reduce toxicity and side effects. With respect to the capability and utilization of cyclodextrin‐based nanoparticles in different aspects of the tumour microenvironment and gut microbiota, a survey of current research papers was conducted via looking through databases including GoogleScholar, PubMed, Web of Science, and Scopus. This review aims to summarize cutting‐edge nanoparticulate‐based technologies and therapies for CRC.

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“…[21,22,23] Moreover, in active tumor targeting, conjugating folic acid and anti-FR antibodies with nanocarriers can considerably raise the internalization efficiency of nanocarriers by cancer cells via folate receptor-mediated endocytosis. [24,25] In this strategy, the cellular uptake of nanocarriers can increase by ten-fold compared with non-targeted drug delivery systems and administration of pure chemotherapeutics. [26] In this study, we applied functionalized fluorescent GQDs as a new selective drug delivery system for targeting of tamoxifen anticancer agent to folate and estrogen receptor positive breast cancer cells with simultaneously applicable in detect, tracing and treatment.…”

Section: Introductionmentioning

confidence: 99%

“…PEGylation of nanoparticles can not only facilitate the passive targeting of cancer cells but also increase their hydrophilicity, avoid the immune system response, and increase the circulation time of nano‐complex in body serum [21,22,23] . Moreover, in active tumor targeting, conjugating folic acid and anti‐FR antibodies with nanocarriers can considerably raise the internalization efficiency of nanocarriers by cancer cells via folate receptor‐mediated endocytosis [24,25] . In this strategy, the cellular uptake of nanocarriers can increase by ten‐fold compared with non‐targeted drug delivery systems and administration of pure chemotherapeutics [26] …”

Section: Introductionmentioning

confidence: 99%

Efficient and Traceable Tamoxifen Delivery to Breast Cancer Cells Using Folic Acid‐Decorated and PEGylated Graphene Quantum Dots

Amraee,

Torbati,

Majd

et al. 2023

ChemistrySelect

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Graphene quantum dots (GQDs) possess potential properties for the targeted transport and tracking of anticancer medication to tumor cells. For this purpose, the synthesized GQDs were decorated with folic acid (FA) and methoxy polyethylene glycol (mPEG2000), and finally loaded with tamoxifen (TMX) drug. The synthesized nano‐drug was characterized using FTIR, XRD, UV‐Vis, PL, HRTEM, FESEM, and DLS analytical devices. Based on the obtained data, the average hydrodynamic diameter of particles dissolved in water was 294.7 nm and the size of dehydrated particles was between 53 and 210 nm. PL data showed that prepared nanoparticles have an emission wavelength of 438 nm, which is in the blue fluorescent wavelength range, thus making these nanoparticles suitable for cell imaging. The encapsulation efficiency and loading percentage of tamoxifen in nanoparticles were calculated at about 52.5 % and 30 %, respectively, and cumulative drug release reached 89 % within 42 hours. The cytotoxicity effects of nanoparticles were investigated. According to IC50 results, the targeted mPEG‐GQDs‐FA/TMX (TMX‐FPGs) nano‐drug was more toxic than free TMX on MCF‐7 cells and had reduced side effects on healthy HDF cells. TMX‐FPGs induced apoptosis cell death, significantly. The confocal imaging experiments showed that TMX‐FPGs are appropriate for monitoring and targeting MCF‐7 cells.

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Folic acid conjugated capecitabine capped green synthesized fluorescent carbon dots as a targeted nano-delivery system for colorectal cancer

Cited by 5 publications

References 44 publications

Carbon Dots: Synthesis, Characterizations, and Recent Advancements in Biomedical, Optoelectronics, Sensing, and Catalysis Applications

Carbon Dots: Synthesis, Characterizations, and Recent Advancements in Biomedical, Optoelectronics, Sensing, and Catalysis Applications

Cyclodextrin based nanoparticles for smart drug delivery in colorectal cancer

Efficient and Traceable Tamoxifen Delivery to Breast Cancer Cells Using Folic Acid‐Decorated and PEGylated Graphene Quantum Dots

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