Foldable three dimensional neural electrode arrays for simultaneous brain interfacing of cortical surface and intracortical multilayers

Abstract

Challenges in the understanding of three-dimensional (3D) brain networks by simultaneously recording both surface and intracortical areas of brain signals remain due to the difficulties of constructing mechanical design and spatial limitations of the implanted sites. Here, we present a foldable and flexible 3D neural prosthetic that facilitates the 3D mapping of complex neural circuits with high spatiotemporal dynamics from the intracortical to cortical region. This device is the tool to map the 3D neural transmission through sophisticatedly designed four flexible penetrating shanks and surface electrode arrays in one integrated system. We demonstrate the potential possibilities of identifying correlations of neural activities from the intracortical area to cortical regions through continuous monitoring of electrophysiological signals. We also exploited the structural properties of the device to record synchronized signals of single spikes evoked by unidirectional total whisker stimulation. This platform offers opportunities to clarify unpredictable 3D neural pathways and provides a next-generation neural interface.

Materials and Structural Designs for Neural Interfaces

“…Third, the self-assembly method is used to construct complex structures from simple structures, which can be applied to various fields of study, including the fabrication of neural interfaces. Such self-assembly methods include using stimuli-responsive materials, mechanically driven assembly, and mechanically guided 3D assembly methods. , Lee et al fabricated foldable 3D neural electrode arrays, consisting of surface electrodes for recording ECoG signals, a Utah array for multisite recording from cortical regions, and a Michigan probe for recording signals from deep tissue layers (Figure g) . The neural interface was fabricated by the series of the detachment of a fabricated device from the substrate, the partial attachment of the device on the prestretched substrate elastomer layer, and the release of the elastomer.…”

“…94,95 4g). 95 The neural interface was fabricated by the series of the detachment of a fabricated device from the substrate, the partial attachment of the device on the prestretched substrate elastomer layer, and the release of the elastomer. This resulted in the pop-up of the fabricated electrodes that functioned as brain-penetrating electrodes.…”

“…Copyright 2017, Springer Nature. (g) Reproduced under a Creative Commons Attribution 4.0 International License (CC BY) . Copyright 2022, Springer Nature.…”

“…Such self-assembly methods include using stimuli-responsive materials, mechanically driven assembly, and mechanically guided 3D assembly methods. 94,95 4g). 95 The neural interface was fabricated by the series of the detachment of a fabricated device from the substrate, the partial attachment of the device on the prestretched substrate elastomer layer, and the release of the elastomer.…”

Fluorescent-based biodegradable microneedle sensor array for tether-free continuous glucose monitoring with smartphone application

“…Recently, research on soft bioelectronics, such as wearable and implantable devices, has been actively conducted (29)(30)(31)(32)(33)(34)(35). These devices, which use biocompatible materials, are being studied for applications in the field of human health, in many forms, including diagnosis, treatment, physiological research, and clinical trials.…”