Folato, vitamina B12 e ferritina sérica e defeitos do tubo neural

Thame, Gizele; Shinohara, Elvira Maria Guerra; Santos, Hosana Gonçalves dos; Moron, Antônio Fernandes

doi:10.1590/s0100-72031998000800004

Cited by 10 publications

(7 citation statements)

References 8 publications

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“…Lack of vitamin B 12 in the maternal diet during pregnancy has been shown to cause severe retardation of myelination in the nervous system of the fetus 2 . Vitamin B 12 deficiency can lead to megaloblastic anaemia and to neuropsychiatric symptoms, which may occur even before the onset of megaloblastic anaemia 2–5 , and may also be involved in the aetiology of neural tube defects 6–8 .…”

Section: Introductionmentioning

confidence: 99%

Relationship between total homocysteine and folate levels in pregnant women and their newborn babies according to maternal serum levels of vitamin B₁₂

Guerra-Shinohara

Paiva

Patrıacute

et al. 2002

BJOG

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Objective To determine total homocysteine and folate levels in pregnant women according to vitamin B 12 (B 12 ) levels, and to analyse the impact of maternal B 12 levels on the nutritional status of their newborn babies. Design Cross sectional observational study.Setting Two public hospitals in Jundiai City, São Paulo, Brazil.Sample Sixty-nine pregnant women and their respective newborn babies at the time of delivery.Methods Maternal blood was collected up to 8 hours before delivery. Umbilical cord blood was collected after the expulsion of the placenta. Total homocysteine was measured by high perfomance liquid chromatography, folate by ion capture methodology and B 12 by enzyme immunoassay. Main outcome measures Relationship between low maternal vitamin B12 levels and total homocysteine and folate levels in pregnant women and newborn babies. Results There was a significant correlation between maternal and neonatal B 12 levels, but not between maternal B 12 and neonatal red blood cell (RBC) folate. There was a weak correlation between maternal B 12 levels and neonatal serum folate. However, there were significant correlations between maternal and neonatal total homocysteine levels and between neonatal B 12 and neonatal total homocysteine levels. Mean (FSD) umbilical cord blood B 12 , RBC folate, serum folate and total homocysteine levels were 1.7 F 0.8, 1.8 F 0.8, 2.2 F 0.8 and 0.9 F 0.3 times higher than maternal B 12 , RBC folate, serum folate and total homocysteine values, respectively. Conclusions These data suggest that pregnant women with low B 12 levels are unable to provide the necessary amount of B 12 to their fetuses. The clinical consequences could be the presence of neurological abnormalities as well as the lack of utilisation of homocysteine for methionine transformation.

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Section: Introductionmentioning

confidence: 99%

Relationship between total homocysteine and folate levels in pregnant women and their newborn babies according to maternal serum levels of vitamin B₁₂

Guerra-Shinohara

Paiva

Patrıacute

et al. 2002

BJOG

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“…To calculate the odds ratio (OR), parameters were considered greater or lesser than the minimum reference limit, which were 3 ng/mL for folic acid and 150 pg/mL for vitamin B12 (Thame et al, 1998); for Hcy the parameter was considered > 12 mM (Vuckovic et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Interactions among methylenetetrahydrofolate reductase (MTHFR) and cystathionine β-synthase (CBS) polymorphisms - a cross-sectional study: multiple heterozygosis as a risk factor for higher homocysteine levels and vaso-occlusive episodes

et al. 2017

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ABSTRACT. High plasma homocysteine (Hcy) levels may be responsible for vaso-occlusive episodes and may have acquired and/or genetic causes. This cross-sectional study aimed to investigate the role of methylenetetrahydrofolate reductase (MTHFR; C677T; A1298C) and cystathionine-b-synthase (CBS; T833C/844ins68, G919A) polymorphisms in serum levels of folic acid, vitamin B12 and Hcy, and to verify a possible association between these polymorphisms and the clinical variability. Blood samples of Brazilian patients with a diagnosis of thrombosis were submitted to genotyping by PCR-based methods and serum dosages of folic acid, vitamin B12 and Hcy. Except for the CBS G919A polymorphism, all other genetic markers were in HardyWeinberg equilibrium. An increased risk for venous thrombosis was found for the MTHFR 1298CC carriers (OR = 1.688; 95%CI = 0.839-3.398, P = 0.018) and those homozygously mutant for the CBS haplotype 844ins68/T833C (OR = 2.488; 95%CI = 0.501-12.363, P = 0.031), while heterozygous for this CBS haplotype showed an increased risk for higher Hcy levels (OR = 5.900; 95%CI = 1.003-34.691, P = 0.030). Significant interactions were observed among the MTHFR C677T, MTHFR A1298C and CBS haplotype 844ins68/T833C polymorphisms in the results for Hcy levels (P = 0.000), where heterozygous had higher values. Interactions among these polymorphisms can affect serum Hcy levels, where multiple heterozygosis could be a risk factor for vasoocclusive episodes.

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“…A ingestão de energia e nutrientes adequados são determinantes para o crescimento e o desenvolvimento do embrião e a saúde da gestante. Entre os nutrientes, o ferro e o ácido fólico têm papel de destaque nos processos como eritropoiese materna e formação de tecido do feto, que ocorrem de forma acelerada 1 .…”

Section: Introdução|unclassified

Uso de suplementos de ácido fólico e ferro em gestantes de uma unidade de saúde do Paraná

Murakami¹,

Höfelmann²

2017

RBPS

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Folato, vitamina B12 e ferritina sérica e defeitos do tubo neural

Cited by 10 publications

References 8 publications

Relationship between total homocysteine and folate levels in pregnant women and their newborn babies according to maternal serum levels of vitamin B₁₂

Relationship between total homocysteine and folate levels in pregnant women and their newborn babies according to maternal serum levels of vitamin B₁₂

Interactions among methylenetetrahydrofolate reductase (MTHFR) and cystathionine β-synthase (CBS) polymorphisms - a cross-sectional study: multiple heterozygosis as a risk factor for higher homocysteine levels and vaso-occlusive episodes

Uso de suplementos de ácido fólico e ferro em gestantes de uma unidade de saúde do Paraná

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Folato, vitamina B12 e ferritina sérica e defeitos do tubo neural

Cited by 10 publications

References 8 publications

Relationship between total homocysteine and folate levels in pregnant women and their newborn babies according to maternal serum levels of vitamin B12

Relationship between total homocysteine and folate levels in pregnant women and their newborn babies according to maternal serum levels of vitamin B12

Interactions among methylenetetrahydrofolate reductase (MTHFR) and cystathionine β-synthase (CBS) polymorphisms - a cross-sectional study: multiple heterozygosis as a risk factor for higher homocysteine levels and vaso-occlusive episodes

Uso de suplementos de ácido fólico e ferro em gestantes de uma unidade de saúde do Paraná

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Product

Resources

About

Relationship between total homocysteine and folate levels in pregnant women and their newborn babies according to maternal serum levels of vitamin B₁₂

Relationship between total homocysteine and folate levels in pregnant women and their newborn babies according to maternal serum levels of vitamin B₁₂