2015
DOI: 10.1186/s12937-015-0006-3
|View full text |Cite
|
Sign up to set email alerts
|

Folate, Vitamin B12 and Homocysteine status in the post-folic acid fortification era in different subgroups of the Brazilian population attended to at a public health care center

Abstract: Background: Folate and vitamin B12 are essential nutrients, whose deficiencies are considerable public health problems worldwide, affecting all age groups. Low levels of these vitamins have been associated with high concentrations of homocysteine (Hcy) and can lead to health complications. Several genetic polymorphisms affect the metabolism of these vitamins. The aims of this study were to assess folate, vitamin B12 and homocysteine status in distinct Brazilian individuals after the initiation of folic acid fo… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

2
29
4
2

Year Published

2016
2016
2020
2020

Publication Types

Select...
8
1
1

Relationship

0
10

Authors

Journals

citations
Cited by 48 publications
(37 citation statements)
references
References 55 publications
(70 reference statements)
2
29
4
2
Order By: Relevance
“…These distributions were similar to previously published Brazilian population data. 21 Stratified analysis was used to assess the distribution of genotypes according to other variables. As expected, both polymorphisms were strongly associated with self-reported skin color (P o 0.001), and for that reason, subsequent analyses were adjusted for this variable.…”
Section: Resultsmentioning
confidence: 99%
“…These distributions were similar to previously published Brazilian population data. 21 Stratified analysis was used to assess the distribution of genotypes according to other variables. As expected, both polymorphisms were strongly associated with self-reported skin color (P o 0.001), and for that reason, subsequent analyses were adjusted for this variable.…”
Section: Resultsmentioning
confidence: 99%
“…To our knowledge, insufficient dietary intake of vitamins B, are supposed as a main cause of hyperhomocysteinemia. Hence, attempts to normalize homocystine level by the supplementation of these vitamins, such as folic acid become the main measure (Barnabé et al, 2015 ). However, Mao et al reported in their study that folic acid in doses 0.4 mg/d and 0.8 mg/d did not lower SBP or DBP, the differences in SBP/DBP change compared to the control group being 0.6/0.0 mmHg (Mao et al, 2008 ).…”
Section: Discussionmentioning
confidence: 99%
“…Otherwise available data indicate both MMPs to be equivalent in their potential to increase Fol-E, although it may still warrant further investigation whether the combination provides superior benefit to women with genetic variants of MTHFR. Interestingly, in countries with mandatory folic acid fortification folate deficiency today appears to be less prevalent, however in a Brazilian study, pregnant women with the MTHFR 677TT genotype appeared to have significantly lower plasma folate levels than women with the wildtype enzyme [30].…”
Section: Discussionmentioning
confidence: 99%