Interactions between lifestyle and MTHFR polymorphisms on homocysteine concentrations in young adults belonging to the 1982 Pelotas Birth Cohort

Oliveira, Isabel; Silva, L P; Borges, Maria Carolina; Cruz, Otávio Martins; Tessmann, Josiane Weber; Motta, J V S; Seixas, Fabiana Kömmling; Horta, Bernardo Lessa; Gigante, Denise Petrucci

doi:10.1038/ejcn.2016.193

Cited by 10 publications

(16 citation statements)

References 49 publications

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“…It should be noted that the Hcy level in homozygous mutant of MTHFR 1298CC was signi cantly lower than that in wild type 1298AA (13.74 vs 19.46) (shown in Table 5). Similar to the results of IO Oliveira's study (42) , compared with 1298AA group, the Hcy concentration of MTHFR 1298 CC decreased in male -10% and in female -5% respectively. In addition to us, Bruno Zappacosta's study (43) got the same result that Hcy value was higher in the wild-type (1298 AA), and lower in the homozygote's mutation (1298 CC).…”

Section: Discussionsupporting

confidence: 87%

WITHDRAWN: Analysis of Hyperhomocysteinemia and Related Factors : A Case - Control Study in Northeast China

Ding

Zhang

Yang

et al. 2021

Preprint

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Objectives. Hyperhomocysteinemia (HHcy) is an easily neglected disease, which can be hidden in the body for many years without signs or symptoms. We want to explore the causes of HHcy, the correlation of HHcy with micronutrients, lifestyle, dietary habits and HHcy related genes, preventing the occurrence of HHcy.Methods. 800 subjects (M/F, 403/397) were divided into normal Hcy and HHcy group according to the plasma levels of Hcy, compared essential characteristics by questionnaires, genetic polymorphism tested by Realtime PCR and micronutrients detected by mass spectrometry. The statistical analysis methods were Chi - square tests, ANOVA, logistic regression. This trial has been registered with the trial number ChiCTR1900025136. Results. 42.66% of 143 HHcy cases were aged from 10 to 18, with higher levels of zinc (Zn), vitamin A, Uric acid (P < 0.05) and a lower level of 25-OH-D3, VB12, folic acid (Fol) (P < 0.05) compared to the normal group. The multivariate logistic regression significantly predicted HHcy development containing higher level of Zinc (Exp(B) = 1.042; 95% CI, 1.000 - 1.086), higher Uric (Exp(B) = 1.014; 95% CI, 1.008 - 1.019), lower B12 (Exp(B) = 0.993; 95%CI, 0.989 - 0.997), lower Folic acid (Exp(B) = 0.772; 95% CI, 0.657 - 0.907), and polymorphism of MTHFR C677T (Exp(B) = 2.923; 95% CI, 1.399–6.107).Conclusion. Pay more attention to those students who were facing great pressure because they are very likely to be potential HHcy patients with high levels of uric acid and zinc and anxiety.

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Section: Discussionsupporting

confidence: 87%

WITHDRAWN: Analysis of Hyperhomocysteinemia and Related Factors : A Case - Control Study in Northeast China

Ding

Zhang

Yang

et al. 2021

Preprint

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“…Homocysteine, an intermediate sulfhydryl-containing amino acid, is synthesized by the liver in a reaction involving the removal of the methyl group from methionine 19 , 20 . High level of Hcy is mainly found in patients with a nutritional deficiency of B vitamins as well as being present in genetic diseases where there is an insufficient level of cystathionine beta-synthase enzyme (CβS) or a mutation inn the enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR).…”

Section: Introductionmentioning

confidence: 99%

Plasma homocysteine concentrations and risk of intracerebral hemorrhage: a systematic review and meta-analysis

Zhou

Liang

et al. 2018

Sci Rep

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Intracerebral hemorrhage (ICH) has the highest mortality rate in all strokes. However, controversy still exists concerning the association between plasma homocysteine (Hcy) and ICH. A systematic review and meta-analysis was conducted using Pubmed, Embase, and Web of Science up to April 18, 2017. Standard mean difference (SMD) for mean differences of plasma Hcy levels with 95% confidence intervals (CI) was calculated. Seven studies including 667 ICH patients and 1821 ischemic stroke patients were identified for meta-analysis. Our results showed that Hcy levels in ICH patients were significantly higher than those in healthy controls (SMD = 0.59, 95% CI = 0.51–0.68, P < 0.001); no statistic differences were found in the comparisons of Hcy levels between ICH and ischemic stroke (SMD = −0.03, 95% CI = −0.13–0.06, P > 0.05); further subgroup analysis of ethnicity (Asians: SMD = 0.57, 95% CI = 0.48–0.66, P < 0.001; Caucasians: SMD = 0.77, 95% CI = 0.51–1.02, P < 0.001) and sample size (small samples: SMD = 0.55, 95% CI = 0.30–0.80, P < 0.001; large samples size: SMD = 0.60, 95% CI = 0.51–0.69, P < 0.001) in relation to Hcy levels between ICH and healthy controls did not change these results. In conclusion, Hcy level may be an aggravating factor in atherosclerosis, which is positively associated with high risk of ICH. Race-specific differences between Asians and Caucasians have no impact on the risk of ICH.

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“…The interaction between micronutrients and genetic variants on cardiometabolic traits was examined by five Brazilian studies (81)(82)(83)(84)(85). A cross-sectional study of 335 healthy young adults (81), observed a pronounced increase in systolic blood pressure (SBP) (P interaction = 0.016) among carriers of the "G" allele of Angiotensinogen (AGT) SNP rs699 with a higher plasma magnesium (209.3 mg).…”

Section: Interactions Between Micronutrients and Genetic Variants On ...mentioning

confidence: 99%

Interactions between genetic and lifestyle factors on cardiometabolic disease-related outcomes in Latin American and Caribbean populations: A systematic review

et al. 2023

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IntroductionThe prevalence of cardiometabolic diseases has increased in Latin American and the Caribbean populations (LACP). To identify gene-lifestyle interactions that modify the risk of cardiometabolic diseases in LACP, a systematic search using 11 search engines was conducted up to May 2022.MethodsEligible studies were observational and interventional studies in either English, Spanish, or Portuguese. A total of 26,171 publications were screened for title and abstract; of these, 101 potential studies were evaluated for eligibility, and 74 articles were included in this study following full-text screening and risk of bias assessment. The Appraisal tool for Cross-Sectional Studies (AXIS) and the Risk Of Bias In Non-Randomized Studies—of Interventions (ROBINS-I) assessment tool were used to assess the methodological quality and risk of bias of the included studies.ResultsWe identified 122 significant interactions between genetic and lifestyle factors on cardiometabolic traits and the vast majority of studies come from Brazil (29), Mexico (15) and Costa Rica (12) with FTO, APOE, and TCF7L2 being the most studied genes. The results of the gene-lifestyle interactions suggest effects which are population-, gender-, and ethnic-specific. Most of the gene-lifestyle interactions were conducted once, necessitating replication to reinforce these results.DiscussionThe findings of this review indicate that 27 out of 33 LACP have not conducted gene-lifestyle interaction studies and only five studies have been undertaken in low-socioeconomic settings. Most of the studies were cross-sectional, indicating a need for longitudinal/prospective studies. Future gene-lifestyle interaction studies will need to replicate primary research of already studied genetic variants to enable comparison, and to explore the interactions between genetic and other lifestyle factors such as those conditioned by socioeconomic factors and the built environment. The protocol has been registered on PROSPERO, number CRD42022308488.Systematic review registrationhttps://clinicaltrials.gov, identifier CRD420223 08488.

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Interactions between lifestyle and MTHFR polymorphisms on homocysteine concentrations in young adults belonging to the 1982 Pelotas Birth Cohort

Cited by 10 publications

References 49 publications

WITHDRAWN: Analysis of Hyperhomocysteinemia and Related Factors : A Case - Control Study in Northeast China

WITHDRAWN: Analysis of Hyperhomocysteinemia and Related Factors : A Case - Control Study in Northeast China

Plasma homocysteine concentrations and risk of intracerebral hemorrhage: a systematic review and meta-analysis

Interactions between genetic and lifestyle factors on cardiometabolic disease-related outcomes in Latin American and Caribbean populations: A systematic review

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