Folate-Targeted Polyethylene Glycol–Modified Photosensitizers for Photodynamic Therapy

Tanshinone IIA Liposomes Treat Doxorubicin-Induced Glomerulonephritis by Modulating the Microenvironment of Fibrotic Kidneys

“…Therefore, researchers believe that the density of PEG modification is more important than its relative MW, and the high-density PEG chains can compensate for the influence of low MW of PEG. 42 Nanoparticles could not be transported in ECM when the modification density was lower than 2 PEG molecules per square nanometer. In contrast, when the modified density reaches 8 PEG molecules per square nanometer, the nanoparticles had good mobility in the ECM and could be effectively transported to the lesion site.…”

“…If the density is too large, then the repulsion between PEG chains will be too large. Therefore, researchers believe that the density of PEG modification is more important than its relative MW, and the high-density PEG chains can compensate for the influence of low MW of PEG . Nanoparticles could not be transported in ECM when the modification density was lower than 2 PEG molecules per square nanometer.…”

Lactic-co-glycolic acid-coated methylene blue nanoparticles with enhanced antibacterial activity for efficient wound healing

“…[1][2][3][4] During the process of developing PDTs, various photosensitizers are used. 5,6 Methylene blue (MB) is a traditional photosensitizer, which absorbs energy in light to reach an excited state, and then transfers the energy to a triplet oxygen to induce a singlet state to play a bactericidal role. 7,8 Although MB has wide applications in dentistry and dermatology, the clinical application of MB is limited mainly because of low singlet oxygen yield, toxicity, and low stability.…”