Photodynamic Therapy in Cancer

Pallavi, Pragya; Girigoswami, Agnishwar; Girigoswami, Koyeli; Hansda, Surajit; Ghosh, Rita

doi:10.1007/978-981-16-1247-3_232-1

Cited by 6 publications

(3 citation statements)

References 77 publications

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“…Then, it is preferable that it is amphiphilic and photostable for it to be able to penetrate different types of tissues. Finally, it should have both a relatively long-life span in the triplet state and be soluble in water [ 118 ].…”

Section: In Vitro and In Vivo Applications Of Aunps For Cancer Therapiesmentioning

confidence: 99%

Cancer Treatment Using Different Shapes of Gold-Based Nanomaterials in Combination with Conventional Physical Techniques

et al. 2023

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The conventional methods of cancer treatment and diagnosis, such as radiotherapy, chemotherapy, and computed tomography, have developed a great deal. However, the effectiveness of such methods is limited to the possible failure or collateral effects on the patients. In recent years, nanoscale materials have been studied in the field of medical physics to develop increasingly efficient methods to treat diseases. Gold nanoparticles (AuNPs), thanks to their unique physicochemical and optical properties, were introduced to medicine to promote highly effective treatments. Several studies have confirmed the advantages of AuNPs such as their biocompatibility and the possibility to tune their shapes and sizes or modify their surfaces using different chemical compounds. In this review, the main properties of AuNPs are analyzed, with particular focus on star-shaped AuNPs. In addition, the main methods of tumor treatment and diagnosis involving AuNPs are reviewed.

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Section: In Vitro and In Vivo Applications Of Aunps For Cancer Therapiesmentioning

confidence: 99%

Cancer Treatment Using Different Shapes of Gold-Based Nanomaterials in Combination with Conventional Physical Techniques

et al. 2023

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“…PTT, however, requires high levels of NIR irradiation with excessive power laser densities to produce the required amount of heat for the photothermal process to be effective. On the other hand, PDT is limited in its efficacy when used against hypoxic tumors since it requires cancer cells to take up PS agents effectively [133][134][135]. In recent research, chemotherapeutic drugs and photodynamic agents were found to be better absorbed when the temperature is raised to nearly 43 • C applying photothermal heating.…”

Section: Mos 2 -Based Pdtmentioning

confidence: 99%

MoS₂ nanocomposites for biomolecular sensing, disease monitoring, and therapeutic applications

Harini,

Girigoswami,

Pallavi

et al. 2023

Nano Futures

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The unique physicochemical properties of MoS2 nanocomposites have drawn escalation in attention for the diagnosis and therapy of cancer. Mostly the 2D forms of MoS2 find application in sensing, catalysis, and theranostics, where it was traditionally applied in lubrication and battery industries as electrodes or intercalating agents. As nanostructures, MoS2 has a very high surface-to-volume ratio, and that helps in the engineering of structures and surfaces to promote absorption of a wide range of therapeutics and biomolecules through covalent or non-covalent interaction. This surface engineering provides excellent colloidal stability to MoS2 and makes them ideal nanomedicines with higher selectivity, sensitivity, and biomarker sensing ability. Furthermore, MoS2 exhibits exceptionally well optical absorption of NIR radiation and photothermal conversion, which helps in the NIR-responsive release of payloads in photothermal and photodynamic therapy. There are several reports that the fabricated MoS2 nanomedicines can selectively counter the tumor microenvironment, which leads to the accumulation of therapeutics or imaging agents in the diseased tissues to improve the therapeutic effects decreasing the adverse effects on the healthy cells. An overview of the basic structure and properties of MoS2 is presented in this article, along with an elaborative description of its morphology. At the same time, an attempt was made in this review to summarize the latest developments in the MoS2 structure, surface engineering, and nanocomposite formulations for improving biocompatibility, bioavailability, biomolecular sensing, and theranostic applications.

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“…Despite the antibacterial and anticancer activity of 5-ALA-PDT, a pro-regenerative nature of 5-ALA-mediated PDT is recently emerging in the literature. Several studies reported the capacity of photodynamic therapy to accelerate skin wound healing by promoting epithelial stem cell functions [14][15][16][17]. However, little is known about the potential healing effects of 5-ALA-PDT in periodontal-related tissues.…”

Section: Introductionmentioning

confidence: 99%

Photodynamic Therapy with Aminolevulinic Acid Enhances the Cellular Activity of Cells Cultured on Porcine Acellular Dermal Matrix Membranes Used in Periodontology

Petrini

D’Amico

Pierfelice

et al. 2023

Gels

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This study aims to test a photodynamic protocol based on a gel containing aminolevulinic acid followed by red-LED (ALAD-PDT) irradiation on human gingival fibroblasts (hGFs) and osteoblasts (hOBs) cultured on a porcine acellular dermal matrix membrane (PADMM). In the previous literature, ALAD-PDT showed solid antibacterial activity and proliferative induction on HGFs cultured on plates and HOBs cultured on a cortical lamina. PADMMs are used in dentistry and periodontology to treat gingival recessions and to increase the tissue thickness in the case of a thin biotype without the risks or postoperative discomfort associated with connective tissue grafts. However, one of the possible complications in this type of surgery is represented by bacterial invasion and membrane exposition during the healing period. We hypothesized that the addition of ALAD-PDT to PADMMs could enhance more rapid healing and decrease the risks connected with bacterial invasion. In periodontal surgery, PADMMs are inserted after a full-thickness flap elevation between the bone and the flap. Consequently, all procedures were performed in parallel on hOBs and hGFs obtained by dental patients. The group control (CTRL) was represented by the unexposed cells cultured on the membranes, group LED (PDT) were the cells subjected to 7 min of red LED irradiation, and ALAD-PDT were the cells subjected to 45 min of ALAD incubation and then to 7 min of red LED irradiation. After treatments, all groups were analyzed for MTT assay and subjected to histological examination at 3 and 7 days and to the SEM observations at 3, 7, and 14 days. Different bone mineralization assays were performed to quantify the effects of ALAD-PDT on hOBs: ALP activity, ALP gene expression, osteocalcin, and alizarin red. The effects of ALAD-PDT on hGFs were evaluated by quantifying collagen 1, fibronectin, and MMP-8. Results showed that ALAD-PDT promoted cellular induction, forming a dense cellular network on hOBs and hGFs, and the assays performed showed statistically significantly higher values for ALAD-PDT with respect to LED alone and CTRLs. In conclusion, ALAD-PDT could represent a promising aid for enhancing the healing of gingival tissues after PADMM applications.

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Photodynamic Therapy in Cancer

Cited by 6 publications

References 77 publications

Cancer Treatment Using Different Shapes of Gold-Based Nanomaterials in Combination with Conventional Physical Techniques

Cancer Treatment Using Different Shapes of Gold-Based Nanomaterials in Combination with Conventional Physical Techniques

MoS₂ nanocomposites for biomolecular sensing, disease monitoring, and therapeutic applications

Photodynamic Therapy with Aminolevulinic Acid Enhances the Cellular Activity of Cells Cultured on Porcine Acellular Dermal Matrix Membranes Used in Periodontology

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Photodynamic Therapy in Cancer

Cited by 6 publications

References 77 publications

Cancer Treatment Using Different Shapes of Gold-Based Nanomaterials in Combination with Conventional Physical Techniques

Cancer Treatment Using Different Shapes of Gold-Based Nanomaterials in Combination with Conventional Physical Techniques

MoS2 nanocomposites for biomolecular sensing, disease monitoring, and therapeutic applications

Photodynamic Therapy with Aminolevulinic Acid Enhances the Cellular Activity of Cells Cultured on Porcine Acellular Dermal Matrix Membranes Used in Periodontology

Contact Info

Product

Resources

About

MoS₂ nanocomposites for biomolecular sensing, disease monitoring, and therapeutic applications