Folate receptor‐targeted ¹⁹F MR molecular imaging and proliferation evaluation of lung cancer

Abstract

1 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018;48:1617-1625.

19F MRI-guided Flexible Low-intensity Focused Ultrasound for Drug Delivery and Molecular Targeted Therapy

“…PFCE and AZD9291 were encapsulated simultaneously in the core and surface, respectively. AZD9291-PFCE NPs with nanoscale size could pass through the tumor vascular endothelial gap to the extravascular tumor tissue via active folic acid targeting, thus overcoming biological barrier for effective tumor treatment, which had been proved by our previous study 33 . Transmission electron microscopy (TEM) images revealed that AZD9291-PFCE NPs have spherical morphology with uniform particle size and distribution (Fig.…”

Intratracheal Delivery of Nano- and Microparticles and Hyperpolarized Gases

“…Indeed, PFC nanoparticles are safe in vitro and in vivo and are constrained to the tumor. 9,15 As PFC has a long history of medical applications as an artificial blood substitute, in liquid ventilation, and as a drug delivery vehicle, 37,40 the logical extension of this work suggests that PFC nanoparticles may represent an important theranostic opportunity to address the formidable challenges in treating lung cancer. More importantly, active targeted PFC nanoparticles show great promise as quantitative biomarkers for lung cancer molecular imaging.…”

“…Given the excellent advantages of 19 F, such as its 100% natural abundance, high gyromagnetic ratio (w95% of 1 H), and high sensitivity of 83%, 9 it is opportune to develop 19 F-MR imaging. In 1996, perfluorocarbon (PFC) partial liquid ventilation was shown to alleviate neonatal respiratory distress syndrome and improve pulmonary function, due to its high oxygendissolving and releasing capability, low surface tension, and excellent physical-chemical properties.…”

“…Nanoparticles with a size range from 1 to 1,000 nm, enabling unique medical effects, 6 have been successfully employed for biomedical applications in the past several decades. 7 To achieve specific imaging and therapeutic effects, nanoparticles can enter the human body via ocular penetration, 8 IV injection, 9 oral administration, 10 and the subcutaneous route. 11 However, factors such as hepatic first-pass metabolism, rapid blood clearance, and high-dose exposure in off-target tissues limit the efficacy of these conventional delivery methods, especially for respiratory disease.…”

Nanotechnology as a Versatile Tool for 19F-MRI Agent’s Formulation: A Glimpse into the Use of Perfluorinated and Fluorinated Compounds in Nanoparticles

“…Using macrocyclic perfluoropolyethers (PFPEs), e.g., the 12, 15, or 18 crown ethers with their high number of equivalent fluorine atoms (16, 20, and 24, respectively) assure an outstanding NMR performance, notably of chemical shift artifacts, SNR, single sharp resonance peak that enable for unambiguous identification, etc. Macrocyclic PFCs such as the perfluoro-15-crown-5 ether (PFCE) assure a substantial improvement in MRI sensitivity with 20 chemically equivalent fluorines (NMR resonance at around ~−92.5 ppm) [98] and is one of the most explored PFC [105][106][107][108][109][110][111][112]. 4.…”