Folate and arsenic metabolism: a double-blind, placebo-controlled folic acid–supplementation trial in Bangladesh

Abstract

These data indicate that folic acid supplementation to participants with low plasma folate enhances arsenic methylation. Because persons whose urine contains low proportions of DMA and high proportions of MMA and InAs have been reported to be at greater risk of skin and bladder cancers and peripheral vascular disease, these results suggest that folic acid supplementation may reduce the risk of arsenic-related health outcomes.

Associations of Plasma Selenium with Arsenic and Genomic Methylation of Leukocyte DNA in Bangladesh

“…For these analyses, we have included baseline data from 195 participants who completed the folic acid intervention study from whom high-quality DNA was obtained (Gamble et al 2006(Gamble et al , 2007. An additional 100 participants were recruited from the HEALS cohort study in order to capture a wider range of As exposure and folate nutritional status.…”

Effects of Prenatal Exposure to Endocrine Disruptors and Toxic Metals on The Fetal Epigenome

“…Importantly, folate supplementation has also been observed to reduce levels of more harmful arsenical species, indicating its potential as an intervention to mitigate the harms of iAs exposure [148]. Relationships between exposure to nutritional factors, such as folate and Vitamin D, have also been observed with respect to endocrine disruptors [149,150].…”

Variations in arsenic methylation capacity and oxidative DNA lesions over a 2-year period in a high arsenic-exposed population

“…Other environmental factors such as diet and lifestyle, may be inXuencing methylation capacity. Nutrition is suggested as a major factor that might aVect arsenic methylation (Gamble et al 2006;Heck et al 2007). Even minor dietary diVerences in some nutrients can contribute to variation in the concentration of blood S-adenosyl-methionine (SAM), the methyl donor for arsenic methylation (Poirier et al 2001).…”