Focused ultrasound-induced blood brain-barrier opening enhanced vascular permeability for GDNF delivery in Huntington's disease mouse model

Lin, Chung-Yin; Tsai, Chih-Hung; Feng, Lin; Chai, Wen-Yen; Lin, Chia‐Jung; Huang, Chung Cheng; Wei, Kuo-Chen; Yeh, Chih‐Kuang; Chen, Chiung‐Mei; Liu, Hao-Li

doi:10.1016/j.brs.2019.04.011

Cited by 42 publications

(25 citation statements)

References 38 publications

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“…Liposome encapsulated drugs for brain delivery with FUS have been used with many drugs and for various applications (Treat et al, 2012; Yang et al, 2012; Lin et al, 2015; Lin et al, 2016; Zhao et al, 2018; Lin et al, 2019). In 2012, liposomal doxorubicin delivery to rat gliosarcoma following FUS-mediated BBB opening was investigated (Treat et al, 2012).…”

Section: Polymer and Lipid-based Nanoparticles For Delivery To The Cnmentioning

confidence: 99%

“…Further, the combination group also had a 24% increase in survival time over the nontreated group. More recently, liposomal glial-derived neurotrophic factor (GDNF) and FUS-induced BBB opening were used for treatment in a mouse model of Huntington’s disease (Lin et al, 2019). Mice were treated with either liposomal GDNF, BBB opening via FUS, or the combination of the two on a weekly basis for a total of 9 weeks and motor function was assessed during this time.…”

Section: Polymer and Lipid-based Nanoparticles For Delivery To The Cnmentioning

confidence: 99%

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Recent Advances in the Use of Focused Ultrasound for Magnetic Resonance Image-Guided Therapeutic Nanoparticle Delivery to the Central Nervous System

Fisher

Price

2019

Front. Pharmacol.

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Targeting systemically-administered drugs and genes to specific regions of the central nervous system (CNS) remains a challenge. With applications extending into numerous disorders and cancers, there is an obvious need for approaches that facilitate the delivery of therapeutics across the impervious blood-brain barrier (BBB). Focused ultrasound (FUS) is an emerging treatment method that leverages acoustic energy to oscillate simultaneously administered contrast agent microbubbles. This FUS-mediated technique temporarily disrupts the BBB, allowing ordinarily impenetrable agents to diffuse and/or convect into the CNS. Under magnetic resonance image guidance, FUS and microbubbles enable regional targeting—limiting the large, and potentially toxic, dosage that is often characteristic of systemically-administered therapies. Subsequent to delivery across the BBB, therapeutics face yet another challenge: penetrating the electrostatically-charged, mesh-like brain parenchyma. Non-bioadhesive, encapsulated nanoparticles can help overcome this additional barrier to promote widespread treatment in selected target areas. Furthermore, nanoparticles offer significant advantages over conventional systemically-administered therapeutics. Surface modifications of nanoparticles can be engineered to enhance targeted cellular uptake, and nanoparticle formulations can be tailored to control many pharmacokinetic properties such as rate of drug liberation, distribution, and excretion. For instance, nanoparticles loaded with gene plasmids foster relatively stable transfection, thus obviating the need for multiple, successive treatments. As the formulations and applications of these nanoparticles can vary greatly, this review article provides an overview of FUS coupled with polymeric or lipid-based nanoparticles currently utilized for drug delivery, diagnosis, and assessment of function in the CNS.

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Section: Polymer and Lipid-based Nanoparticles For Delivery To The Cnmentioning

confidence: 99%

Section: Polymer and Lipid-based Nanoparticles For Delivery To The Cnmentioning

confidence: 99%

Recent Advances in the Use of Focused Ultrasound for Magnetic Resonance Image-Guided Therapeutic Nanoparticle Delivery to the Central Nervous System

Fisher

Price

2019

Front. Pharmacol.

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“…Nanomedicine has offered better nanodelivery systems for gene therapy [2]. Promising results also yielded by combining treatment strategies, i.e., focused ultrasound, in order to enhance vascular permeability and open BBB for delivering liposomes carrying plasmids for gene therapy of HD [35]. Moreover, nanomedical advances also contribute to the construction of better research mechanistic models in order to investigate the molecular pathophysiology of neurodegenerative movement disorders such as HD, giving as well insights of their clinical manifestations [25].…”

Section: Neurodegenerative Diseasesmentioning

confidence: 99%

Nanotechnology in neurosurgery: a systematic review

Giakoumettis

Sgouros

2021

Childs Nerv Syst

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Background The application of nanotechnology in medicine encompasses an interdisciplinary field of sciences for the diagnosis, treatment, and monitoring of medical conditions. This study aims to systematically review and summarize the advances of nanotechnology applicable to neurosurgery. Methods We performed a PubMed advanced search of reports exploring the advances of nanotechnology and nanomedicine relating to diagnosis, treatment, or both, in neurosurgery, for the last decade. The search was performed according to PRISMA guidelines, and the following data were extracted from each paper: title; authors; article type; PMID; DOI; year of publication; in vitro, in vivo model; nanomedical, nanotechnological material; nanofield; neurosurgical field; the application of the system; and main conclusions of the study. Results A total of 78 original studies were included in this review. The results were organized into the following categories: functional neurosurgery, head trauma, neurodegenerative diseases, neuro-oncology, spinal surgery and peripheral nerves, vascular neurosurgery, and studies that apply to more than one field. A further categorization applied in terms of nanomedical field such as neuroimaging, neuro-nanotechnology, neuroregeneration, theranostics, and neuro-nanotherapy. Conclusion In reviewing the literature, significant advances in imaging and treatment of central nervous system diseases are underway and are expected to reach clinical practice in the next decade by the application of the rapidly evolving nanotechnology techniques.

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“…We considered that a similar situation occurred when pDNA was transfected to the brain using the combination of ultrasound and Ang2-modified cationic nanobubbles mentioned above. Many research groups have reported the effects of BBB opening and the potential applications of gene therapy using pDNA, siRNA, or AAV [ 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 ]. In a clinical setting, the state-of-the-art MRI-guided focused low-intensity ultrasound was used for a patient with a malignant brain tumor to deliver chemotherapeutic agents in 2015 [ 94 ].…”

Section: Various Ultrasound Devices and Ultrasound Delivery In CLImentioning

confidence: 99%

Microbubbles and Nanobubbles with Ultrasound for Systemic Gene Delivery

Endo‐Takahashi

Negishi

2020

Pharmaceutics

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The regulation of gene expression is a promising therapeutic approach for many intractable diseases. However, its use in clinical applications requires the efficient delivery of nucleic acids to target tissues, which is a major challenge. Recently, various delivery systems employing physical energy, such as ultrasound, magnetic force, electric force, and light, have been developed. Ultrasound-mediated delivery has particularly attracted interest due to its safety and low costs. Its delivery effects are also enhanced when combined with microbubbles or nanobubbles that entrap an ultrasound contrast gas. Furthermore, ultrasound-mediated nucleic acid delivery could be performed only in ultrasound exposed areas. In this review, we summarize the ultrasound-mediated nucleic acid systemic delivery system, using microbubbles or nanobubbles, and discuss its possibilities as a therapeutic tool.

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Focused ultrasound-induced blood brain-barrier opening enhanced vascular permeability for GDNF delivery in Huntington's disease mouse model

Cited by 42 publications

References 38 publications

Recent Advances in the Use of Focused Ultrasound for Magnetic Resonance Image-Guided Therapeutic Nanoparticle Delivery to the Central Nervous System

Recent Advances in the Use of Focused Ultrasound for Magnetic Resonance Image-Guided Therapeutic Nanoparticle Delivery to the Central Nervous System

Nanotechnology in neurosurgery: a systematic review

Microbubbles and Nanobubbles with Ultrasound for Systemic Gene Delivery

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