Focused OCT and LIF endoscope

Wall, R. Andrew; Bonnema, Garret T.; Barton, Jennifer K.

doi:10.1117/12.842659

Cited by 3 publications

(3 citation statements)

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“…For the OCT modality, an edge response method previously described in detail was used to calculate the experimental resolution of the constructed system. 19,20 The FWHM lateral OCT resolution of the system was calculated to be approximately 4 μm, which compares favorably with the theoretical value of 3.9 μm.…”

Section: Dual Modality Resolutionsupporting

confidence: 75%

Fluorescence-based surface magnifying chromoendoscopy and optical coherence tomography endoscope

Wall¹,

Barton²

2012

SPIE Proceedings

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A side-viewing, 2.3-mm diameter, surface magnifying chromoendoscopy-optical coherence tomography (SMC-OCT) endoscope has been designed for simultaneous, nondestructive surface fluorescence visualization and cross-sectional imaging. We apply this endoscope to in vivo examination of the mouse colon. A 30,000 element fiber bundle is combined with single mode fibers, for SMC and OCT imaging, respectively. The distal optics consist of a gradient-index lens and spacer to provide a 1× magnification at a working distance of 1.58 mm in air, necessary to image the sample through a 0.23-mm thick outer glass envelope, and an aluminized right-angle prism fixed to the distal end of the gradient-index lens assembly. The resulting 1∶1 imaging system is capable of 3.9-μm lateral and 2.3-μm axial resolution in the OCT channel, and 125-lp∕mm resolution across a 0.70-mm field of view in the SMC channel. The endoscope can perform high contrast crypt visualization, molecular imaging, and crosssectional imaging of colon microstructure.

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Section: Dual Modality Resolutionsupporting

confidence: 75%

Fluorescence-based surface magnifying chromoendoscopy and optical coherence tomography endoscope

Wall¹,

Barton²

2012

SPIE Proceedings

Self Cite

View full text Add to dashboard Cite

show abstract

“…19,20 The FWHM lateral OCT resolution of the system was calculated to be approximately 4 μm, which compares favorably with the theoretical value of 3.9 μm.…”

Section: Dual Modality Resolutionsupporting

confidence: 60%

Fluorescence-based surface magnifying chromoendoscopy and optical coherence tomography endoscope

Wall

Barton

2012

J. Biomed. Opt

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Abstract. A side-viewing, 2.3-mm diameter, surface magnifying chromoendoscopy-optical coherence tomography (SMC-OCT) endoscope has been designed for simultaneous, nondestructive surface fluorescence visualization and cross-sectional imaging. We apply this endoscope to in vivo examination of the mouse colon. A 30,000 element fiber bundle is combined with single mode fibers, for SMC and OCT imaging, respectively. The distal optics consist of a gradient-index lens and spacer to provide a 1× magnification at a working distance of 1.58 mm in air, necessary to image the sample through a 0.23-mm thick outer glass envelope, and an aluminized right-angle prism fixed to the distal end of the gradient-index lens assembly. The resulting 1∶1 imaging system is capable of 3.9-μm lateral and 2.3-μm axial resolution in the OCT channel, and 125-lp∕mm resolution across a 0.70-mm field of view in the SMC channel. The endoscope can perform high contrast crypt visualization, molecular imaging, and crosssectional imaging of colon microstructure.

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“…A couple of designs for dual-modal endoscopes have been proposed and demonstrated. One design used multiple optical fibers with one for sending/receiving OCT source/backscattered light, another for delivery fluorescence excitation and a third for collecting fluorescence emission [ 15 ]. Another design used double-clad fiber (DCF) in conjunction with a fiber-optic rotary joint to construct an endoscope probe [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

An all-fiber-optic endoscopy platform for simultaneous OCT and fluorescence imaging

Mavadia¹,

Xi²,

Chen³

et al. 2012

Biomed. Opt. Express

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We present an all-fiber-optically based endoscope platform for simultaneous optical coherence tomography (OCT) and fluorescence imaging. This design entails the use of double-clad fiber (DCF) in the endoscope for delivery of OCT source and fluorescence excitation light while collecting the backscattered OCT signal through the single-mode core and fluorescence emission through the large inner cladding of the DCF. Circumferential beam scanning was performed by rotating a 45° reflector using a miniature DC motor at the distal end of the endoscope. Additionally, a custom DCF coupler and a wavelength division multiplexer (WDM) were utilized to seamlessly integrate both imaging modalities to achieve an entirely fiber-optically based dual-modality imaging system. We demonstrated simultaneous intraluminal 3D OCT and 2D (surface) fluorescence imaging in ex vivo rabbit esophagus using the dual-modal endomicroscopy system. Structural morphologies (provided by OCT) and fluorophore distribution (provided by the fluorescence module) could be clearly visualized, suggesting the potential of the dual-modality system for future in vivo and clinical applications.

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Focused OCT and LIF endoscope

Cited by 3 publications

References 0 publications

Fluorescence-based surface magnifying chromoendoscopy and optical coherence tomography endoscope

Fluorescence-based surface magnifying chromoendoscopy and optical coherence tomography endoscope

Fluorescence-based surface magnifying chromoendoscopy and optical coherence tomography endoscope

An all-fiber-optic endoscopy platform for simultaneous OCT and fluorescence imaging

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