Focused Microwave-Assisted Extraction and LC Determination of Ketoprofen in the Presence of Preservatives in a Pharmaceutical Cream Formulation

Labbozzetta, Stefano; Valvo, Luisa; Bertocchi, Paola; Alimonti, S.; Gaudiano, Maria Cristina; Manna, Livia

doi:10.1365/s10337-008-0892-z

Cited by 11 publications

(10 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The sustainability of the proposed process is promising when compared to others reported in literature. Some processes were suggested aimed at recovering naproxen, ketoprofen, and ibuprofen from pharmaceutical formulations, e.g., suppositories, topical creams, and tablets. Even though speeding up the recovery process, the use of microwave-assisted methods, e.g., microwave irradiation of 2450 MHz, , and/or high temperatures (≥35 °C, 65 °C, and 70 °C) generate high energetic inputs.…”

Section: Resultsmentioning

confidence: 99%

Recovery of Nonsteroidal Anti-Inflammatory Drugs from Wastes Using Ionic-Liquid-Based Three-Phase Partitioning Systems

Silva

Caban

Kholany

et al. 2018

ACS Sustainable Chem. Eng.

View full text Add to dashboard Cite

Aiming at outlining new strategies for the valorization of solid pharmaceutical wastes as viable alternatives to incineration, this work proposes the use of ionic liquids-based three phase partitioning (IL-based TPP) systems. Ibuprofen, naproxen, and ketoprofen, all belonging to the class of nonsteroidal anti-inflammatory drugs (NSAIDs), were adopted as model compounds. An integrated process has been conceptualized based on three steps: (1) extraction and purification of NSAIDs using the IL-based TPP systems, (2) drug isolation by precipitation with antisolvents, and (3) recycling and reusing the solvents. With the optimization of steps 1 and 2 as objects of this investigation, aqueous biphasic systems (ABS) composed of three distinct ILs (tetrabutylammonium chloride, 1-butyl-3-methylimidazolium chloride, and benzyldimethyl(2-hydroxyethyl)ammonium chloride) and potassium citrate buffer were studied. The corresponding IL-based TPP systems were further applied in the purification of each NSAID, and different antisolvents (citric acid aqueous solutions for ibuprofen and naproxen and aluminum sulfate aqueous solutions for ketoprofen) were evaluated as precipitating agents to isolate each drug. The success of the process developed is demonstrated by extraction efficiencies higher than 83.8 ± 7.7% attained in step 1 and isolation efficiencies higher than 76.2 ± 1.8% in step 2. The stability of the three NSAIDs in IL-based aqueous matrices was additionally checked by using a protocol adapted from the OECD guidelines. The economic efficiency and environmental benignity of the process herein developed is underlined, based on not only the low cost of the solvents chosen but also the possibility of recycling and reusing the phase-forming components and antisolvents employed.

show abstract

Section: Resultsmentioning

confidence: 99%

Recovery of Nonsteroidal Anti-Inflammatory Drugs from Wastes Using Ionic-Liquid-Based Three-Phase Partitioning Systems

Silva

Caban

Kholany

et al. 2018

ACS Sustainable Chem. Eng.

View full text Add to dashboard Cite

show abstract

“…This law makes that the interaction between the analytes in a matrix and the extractant is better and the extraction is more efficient [22]. There are some examples of focused microwave extraction that improve the extraction of polar and non-polar compounds in different matrixes as the extraction of ketoprofen in pharmaceutical cream formulation [37], the extraction of heterocyclic amines in meat [38] or in order to clarify the possible hazard of acidic pharmaceuticals (ibuprofen, naproxen, ketoprofen, and diclofenac) in river water and sediments [39]. Using microwave in solid samples allows more efficient and faster sample treatment, so it is being more used in analysis laboratories.…”

Section: Determination Of Vanillin In Extractsmentioning

confidence: 99%

Antioxidant Capacity in Vanilla Extracts Obtained by Applying Focused Microwaves

Rojas-López¹,

Cañizares-Macías²

2013

FNS

View full text Add to dashboard Cite

ORAC method and a continuous flow injection method based on Folin-Ciocalteau reaction (FI-FC) were used for determining the antioxidant activity in extracts obtained by using focused microwaves. Analysis of the antioxidant capacity (AC) of the main compounds of vanilla (vanillin, p-hydroxybenzaldehyde, p-hydroxybenzoic acid and vanillic acid) was also carried out. Vanilla extracts obtained by using focused microwaves had a higher AC (between 72% and 117%) than the obtained by conventional methods. Vanillin had a linear correlation with the antioxidant capacity of the extracts and it is the most influential compound in the antioxidant power. The AC calculated by the ORAC method and the FI-FC method had a ratio 2:1 because of different kinetics and reaction mechanisms of the antioxidants with the reagents, so it is necessary more than one method to establish the antioxidant power in food. On base on the results of the present study microwaves energy can be used to obtain vanilla extracts to improve the AC of them.

show abstract

“…A range of different analytical methods have been used for the determination of ketoprofen in pharmaceutical formulations. These techniques including UV-spectrophotometry [8][9][10][11][12], capillary zone electrophoresis [13], high-performance liquid chromatography [14][15][16][17][18], voltametric methods [19,20], electrokinetic chromatography [21], and quantitative Fourier transform infrared spectroscopy using attenuated total reflectance analysis [22]. In addition, flow injection technique conjugated with other techniques have been also used for determination of ketoprofen, such as flowinjection technique with chemiluminescence [23,24] and flow injection with UV-detection [25].…”

Section: Introductionmentioning

confidence: 99%

Determination of ketoprofen in tablet dosage forms by derivative IR spectroscopy

Azeez¹,

Fakhre²

2021

Egypt. J. Chem.

View full text Add to dashboard Cite

The study as a simple and rapid method has been described for determination of ketoprofen depending upon normal and first derivative IR Spectroscopy. The aim of this study is to develop a specific, precise and accurate spectroscopic methods that could be applied in quality control for the determination of ketoprofen in pharmaceutical formulations. Ketoprofen has been determined quantitatively in the range of (1000 to 4000)μg/ml depending on the measurement of transmittance for normal and its first derivative spectrum against the concentration with relative error+4.33% and 4.78% and RSD 1.15% and 1.37%, respectively. The values of r 2 of the both methods were 0.993 and 0.978, respectively. The methods have been applied for determination of ketoprofen in some pharmaceutical samples with recovery 97.691%.The obtained results were statistically compared to those of a reported HPLC technique and t-student's and F-tests at P=0.05 are calculated2SA1`

show abstract

Focused Microwave-Assisted Extraction and LC Determination of Ketoprofen in the Presence of Preservatives in a Pharmaceutical Cream Formulation

Cited by 11 publications

References 27 publications

Recovery of Nonsteroidal Anti-Inflammatory Drugs from Wastes Using Ionic-Liquid-Based Three-Phase Partitioning Systems

Recovery of Nonsteroidal Anti-Inflammatory Drugs from Wastes Using Ionic-Liquid-Based Three-Phase Partitioning Systems

Antioxidant Capacity in Vanilla Extracts Obtained by Applying Focused Microwaves

Determination of ketoprofen in tablet dosage forms by derivative IR spectroscopy

Contact Info

Product

Resources

About