Determination of ketoprofen in tablet dosage forms by derivative IR spectroscopy

Abstract

The study as a simple and rapid method has been described for determination of ketoprofen depending upon normal and first derivative IR Spectroscopy. The aim of this study is to develop a specific, precise and accurate spectroscopic methods that could be applied in quality control for the determination of ketoprofen in pharmaceutical formulations. Ketoprofen has been determined quantitatively in the range of (1000 to 4000)μg/ml depending on the measurement of transmittance for normal and its first derivative spectrum against the concentration with relative error+4.33% and 4.78% and RSD 1.15% and 1.37%, respectively. The values of r 2 of the both methods were 0.993 and 0.978, respectively. The methods have been applied for determination of ketoprofen in some pharmaceutical samples with recovery 97.691%.The obtained results were statistically compared to those of a reported HPLC technique and t-student's and F-tests at P=0.05 are calculated2SA1`

Hollow Particles Obtained by Prilling and Supercritical Drying as a Potential Conformable Dressing for Chronic Wounds

“…The results obtained by infrared spectroscopy (FTIR-ATR) [ 43 ] are shown in Figure 5 , reporting the spectra of the pure ketoprofen, the alginate, and the loaded aerogel containing 20% of ketoprofen. Two peaks were observed in the stretching region (C=O) for the pure ketoprofen, between 1667 and 1555 cm −1 , which represents the vibrational stretching of the carboxylic group and the vibrational stretching of the carbonyl in the ketonic group, respectively [ 44 ]. In the loaded aerogels, these peaks were not presented, and this could be due to its shift to lower wavelength numbers being covered by the stretching of the alginate carboxylic group, caused by the formation of hydrogen bonds between the alginate and the ketoprofen and the formation of interactions between the hydroxyl groups of ketoprofen and the Ca 2+ present in the gel matrix of the polymeric particles [ 45 ].…”

Analytical Methods for Determination of Ketoprofen Drug: A review

“…The r 2 coefficients for both techniques were 0.993 and 0.978, respectively. The procedures were used to determine ketoprofen in various pharmaceutical samples, with a recovery rate of 97.691% [14].…”

Innovative localized surface plasmon resonance sensing technique for a green spectrofluorimetric assay of ketoprofen, paracetamol and chlorzoxazone in pharmaceutical preparations and biological fluids

“…The authors declare that they have no conict of interest. Normal condition Type of method: direct or indirect (5) Direct Scale of extraction (6) Micro-extraction Solvents/reagents used (7) Green solvents/reagents used Additional treatments (8) Simple treatments (clean up, solvent removal, etc. )…”

“…Different methods were published for the determination of KPN including ion pair chromatography, 5 derivative IR (infrared) spectroscopy, 6 HPLC, 7 electrochemical method, 8 chromatography tandem mass spectrometry 9,10 and terbium sensitized luminescence method. 11 However, most of these methods have some limitations, such as complicated pre-treatment, wasting of time and possible pollution of the environment.…”