Focused Low-Intensity Pulsed Ultrasound Enhances Bone Regeneration in Rat Calvarial Bone Defect through Enhancement of Cell Proliferation

Focused Low-intensity Pulsed Ultrasound Affects Extracellular Matrix Degradation via Decreasing Chondrocyte Apoptosis and Inflammatory Mediators in a Surgically Induced Osteoarthritic Rabbit Model

“…However, unfocused US did not modify cell apoptosis and proliferation Zeng et al 2012). Recently, a FLIPUS technique was applied to heal bone defects (Jung et al 2015). However, few investigations of the application of this technique to healing cartilage have been conducted.…”

“…Although pressure waves propagated by US transfer mechanical energy into tissue (Gleizal et al 2006;Reher et al 1997), energy from unfocused US can diffuse and destroy adjacent structures (Jung et al 2015). Previous work suggests that focused low-intensity pulsed ultrasound (FLIPUS) improves re-ossification by enhancing cell proliferation in calvarial defect sites in rats (Jung et al 2015). However, few applications of FLI-PUS have been published that describe healing cartilage.…”

The Effects of Low Frequency Ultrasound on Serum Levels of Testosterone in Male Rats

“…The results of research indicate that ultrasound waves might be applied in modulation of cardiac rhythm in neonatal rat ventricular cardiomyocytes [9]. Focused low-intensity pulsed ultrasound also can enhance bone regeneration in rat [10]. The results of studies also demonstrate alterations induced by ultrasound in the connective tissue of the cervix and suggests the therapeutic application of ultrasound for the facilitation of labor and delivery [11].…”

Influence of Low-Intensity Pulsed Ultrasound Stimulation on Expression of Bone-Related Genes in Rat Bone Marrow Cells

“…Jung et al also suggested that focused LIPUS treatment can improve reossification through the enhancement of cell proliferation in calvarial defect sites 12) . Thus, it seems that whether or not LIPUS stimulates cell proliferation depends on the cell type tested and the stimulation condition.…”