Focused Low-intensity Pulsed Ultrasound Affects Extracellular Matrix Degradation via Decreasing Chondrocyte Apoptosis and Inflammatory Mediators in a Surgically Induced Osteoarthritic Rabbit Model

Jia, Lang; Chen, Jinyun; Wang, Yan; Zhang, Yu; Chen, Wenzhi

doi:10.1016/j.ultrasmedbio.2015.08.010

Cited by 26 publications

(31 citation statements)

References 51 publications

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“…The cartilage of lateral and medial femoral condyle was the tissue being targeted. The Model CZG200 Ultrasound Therapeutic Device for Arthritis used (Chongqing Haifu Medical Technology Co. Ltd., China) had an ultrasonic transducer diameter of 25 mm, a radius-of-curvature of 28 mm, a frequency of 0.6 MHz, a pulse repetition frequency of 300 Hz, a spatial and temporal average intensity (I sta ) of 120 mW/cm 2 , and a duty cycle of 20% 28 29 . The ellipsoid-shaped acoustic focus was 0.25 mm in diameter and 0.54 mm in length, measured at the full width at half-maximum of the acoustic intensity 30 .…”

Section: Methodsmentioning

confidence: 99%

Efficacy of focused low-intensity pulsed ultrasound therapy for the management of knee osteoarthritis: a randomized, double blind, placebo-controlled trial

Jia

Wang

Chen

et al. 2016

Sci Rep

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The aim of this study was to investigate the effects of focused low-intensity pulsed ultrasound (FLIPUS) therapy on the functional and health status of patients with knee osteoarthritis (KOA). A total of 106 subjects with bilateral KOA were randomized sequentially into two groups. Group I received FLIPUS + diclofenac sodium, and group II received sham FLIPUS + diclofenac sodium. The therapeutic effects of the interventions were evaluated by measuring changes in VAS pain, the WOMAC scores, and the LI scores after 10 days of treatment as well as changes in LI and VAS at follow-up, 4 and 12 weeks later. In addition, changes in the range of motion, ambulation speed, and the SF-36 in each group were recorded after 10 days of treatment. Compared with those in group II, patients in group Ishowed significant improvements in VAS, WOMAC, LI, ambulation speed, and most items in the SF-36 after 10 days of treatment. In addition, patients in group I showed significant improvements in LI and VAS at follow-up. There were no FLIPUS-related adverse events during and after the interventions. In conclusion, FLIPUS is a safe and effective treatment modality for relieving pain and improving the functions and quality of life of patients with KOA.

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Section: Methodsmentioning

confidence: 99%

Efficacy of focused low-intensity pulsed ultrasound therapy for the management of knee osteoarthritis: a randomized, double blind, placebo-controlled trial

Jia

Wang

Chen

et al. 2016

Sci Rep

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“…The assumption that instruments and methods used to assess LIPUS outcome were carefully chosen, calibrated, valid, and reliable, along with the fact that ultrasound can propagate in the human knee [56] , tends to heighten the credibility and possible clinical relevance of the cummulative body of preclinical findings. Parallel research in advance of clinical trials, also provides further support for a variety of plausible biophysical mechanisms of action to explain LIPUS outcomes, that are highly consistent with known mechanotransducer effects on anabolic as well as catabolic chondrocyte pathways [57][58][59][60] , and potential osteoarthritis related therapeutic genes [32] .…”

Section: Discussionmentioning

confidence: 72%

Low Intensity Pulsed Ultrasound and Articular Cartilage Repair

Marks

2019

International Journal of Orthopaedics

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Low intensity pulsed ultrasound [LIPUS], a physical modality that has demonstrated utility in bone healing contexts including non union fracture situations has been proposed to also impact articular cartilage chondrocyte cell metabolism in a favorable way. This current review focuses on two questions: a) whether LIPUS produces any clinically significant impact on chondrocyte structure or function; b) whether the impacts observed support a role for LIPUS in efforts to foster cartilage regeneration and healing applications. Drawn from the English language literature published over the last 35 years, the majority of the available basic or preclinical studies presently reviewed demonstrate LIPUS applications to consistently yield favorable cartilage chondrogenic responses, regardless of substrate, and to be worthy of further exploration in the clinical realm for promoting much sought

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“…6 Pulsed ultrasound at 1.0 MHZ applied through the patella and soft tissue to stimulate the cartilage directly, and also protect cartilage by decreasing the Joint Effusion volume, pro inflammatory mediators, cell apoptosis, and also inducing cell proliferation. 7 Recently, pulsed US applied using a low intensity (<1 W/cm 2 ) and low frequency (<1 MHZ) had positive effect on patients with Knee OA, including alleviating joint pain, relieving swelling, increasing joint mobility and reducing inflammation. 8 Ozgonelel et al conducted a randomized double blind, placebo controlled study the effects of therapeutic pulsed ultrasound treatment and placebo treatment results showed a statistically significant improvement in pain, difference in recovery in the pulsed ultrasound group in terms of VAS score.…”

Section: Resultsmentioning

confidence: 99%

Effects of low intensity pulsed ultrasound to reduce the effusion volumes and pain with knee osteoarthritis: a randomized controlled trial

Raju¹,

Chokkarapu²,

Harshavardhan³

et al. 2018

Int J Res Orthop

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Background: The study aim was to determine the effect of low intensity pulsed ultrasound therapy to reduce the effusion volumes and pain in patients with Knee OA.Methods: This study design was randomized controlled trial. Total 50 patients diagnosed with Knee osteoarthritis were randomly assigned to two groups. Group I was using treatment of low intensity pulsed ultrasound therapy and group II was administered TENS with home exercise respectively. Treatments were 6 days per week and duration of 2 week. The amount of effusion volume will be measured via ultrasonograpy in knee.Results: The maximum number of cases are lying in age group >60 years which is 28% and 40% in cases and control group respectively and age distribution in both the group is statistically not significant. The mean age of patients in cases and control group is 57.08±7.40 years and 58.04±9.93 years respectively.Conclusions: Low intensity pulsed ultrasound therapy significantly reduced the effusion volumes and pain in patients with knee osteoarthritis.

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Focused Low-intensity Pulsed Ultrasound Affects Extracellular Matrix Degradation via Decreasing Chondrocyte Apoptosis and Inflammatory Mediators in a Surgically Induced Osteoarthritic Rabbit Model

Cited by 26 publications

References 51 publications

Efficacy of focused low-intensity pulsed ultrasound therapy for the management of knee osteoarthritis: a randomized, double blind, placebo-controlled trial

Efficacy of focused low-intensity pulsed ultrasound therapy for the management of knee osteoarthritis: a randomized, double blind, placebo-controlled trial

Low Intensity Pulsed Ultrasound and Articular Cartilage Repair

Effects of low intensity pulsed ultrasound to reduce the effusion volumes and pain with knee osteoarthritis: a randomized controlled trial

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