Focus on blood pressure as a major risk factor

Kahan, Thomas

doi:10.1016/s0140-6736(14)60896-5

Cited by 9 publications

(8 citation statements)

References 12 publications

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“…Hypertension is a chronic medical condition in which the arterial blood pressure (BP) is elevated. It is a well-defined risk factor for many diseases such as coronary heart diseases, atherosclerosis, and stroke [ 1 ], in addition to kidney and cerebrovascular complications [ 2 ]. In the last decades, hypertension becomes one of the most common preventable causes of premature mortality worldwide.…”

Section: Introductionmentioning

confidence: 99%

Antihypertensive Effects of Roselle‐Olive Combination in L‐NAME‐Induced Hypertensive Rats

Abdel-Rahman

Hessin

Abdelbaset

et al. 2017

Oxidative Medicine and Cellular Longevity

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This study aimed to evaluate the antihypertensive efficacy of a new combination therapy of Hibiscus sabdariffa and Olea europaea extracts (2 : 1; Roselle-Olive), using N(G)-nitro-L-arginine-methyl ester- (L-NAME-) induced hypertensive model. Rats received L-NAME (50 mg/kg/day, orally) for 4 weeks. Concurrent treatment with Roselle-Olive (500, 250, and 125 mg/kg/day for 4 weeks) resulted in a dose-dependent decrease in both systolic and diastolic blood pressure, reversed the L-NAME-induced suppression in serum nitric oxide (NO), and improved liver and kidney markers, lipid profile, and oxidative status. Furthermore, Roselle-Olive significantly lowered the elevated angiotensin-converting enzyme activity (ACE) and showed a marked genoprotective effect against oxidative DNA damage in hypertensive rats. Roselle-Olive ameliorated kidney and heart lesions and reduced aortic media thickness. Real-time PCR and immunohistochemistry showed an enhanced endothelial nitric oxide synthase (eNOS) gene and protein expression in both heart and kidney of Roselle-Olive-treated rats. To conclude, our data revealed that Roselle-Olive is an effective combination in which H. sabdariffa and O. europaea synergistically act to control hypertension. These effects are likely to be mediated by antioxidant and genoprotective actions, ACE inhibition, and eNOS upregulation by Roselle-Olive constituents. These findings provide evidences that Roselle-Olive combination affords efficient antihypertensive effect with a broad end-organ protective influence.

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Section: Introductionmentioning

confidence: 99%

Antihypertensive Effects of Roselle‐Olive Combination in L‐NAME‐Induced Hypertensive Rats

Abdel-Rahman

Hessin

Abdelbaset

et al. 2017

Oxidative Medicine and Cellular Longevity

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“…However, this finding does not appear to be valid when lifetime risk (which is more close to a "real life" setting) is taken into consideration [1,3]. This concept provides support for starting treatment in patients with mild hypertension in a younger age [1,3]. Besides, the comparison of the accuracy of 10-year Framingham risk score vs. the Multi-Ethnic Study of Atherosclerosis (MESA) age-adjusted 10-year risk for CVD and vs. the lifetime risk (LTR) for CVD shows that the longer the time of risk estimate and the greater the number of risk factors included the more accurate is the prediction [4].…”

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confidence: 89%

“…Two years ago, a meta-analysis of 11 randomized controlled trials (RCTs) including 8,912 participants (mean follow-up 4-5 years) suggested that in patients with stage I hypertension (systolic BP 140-159 mmHg and/or diastolic BP 90-99 mmHg) antihypertensive drugs do not reduce total mortality, coronary heart disease (CHD), stroke or total CVD events compared with placebo [2]. However, this finding does not appear to be valid when lifetime risk (which is more close to a "real life" setting) is taken into consideration [1,3]. This concept provides support for starting treatment in patients with mild hypertension in a younger age [1,3].…”

mentioning

confidence: 99%

“…Data from a population of 330,000 subjects from Sweden showed that among hypertensive patients > 30 years-old, only 27% had a BP < 140/90 mmHg [6]. Thus, a lot has to be done to improve adherence to antihypertensive treatment and control, mainly with appropriate drug selection and/or with antihypertensive drug combinations [3]. For this reason it is very important to assess global CVD risk to improve the management of the individual patient [1,3].…”

mentioning

confidence: 99%

“…Thus, a lot has to be done to improve adherence to antihypertensive treatment and control, mainly with appropriate drug selection and/or with antihypertensive drug combinations [3]. For this reason it is very important to assess global CVD risk to improve the management of the individual patient [1,3]. Despite the fact that there are many effective antihypertensive drugs at our disposal, the lifetime burden of hypertension remains high [1].…”

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confidence: 99%

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EDITORIAL-Blood Pressure as a Risk Factor of Global Disease Burden and its Association with Lifetime Risks of Different Manifestations of Cardiovascular Disease

Doumas¹,

Τζιόμαλος

Athyros³

2014

TOHYPERJ

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The evaluation of lifetime cardiovascular disease (CVD) risk and the life-years lost due to CVD in specific age groups in a population of 1.25 million people showed that not all elements of hypertension are causally associated with all manifestations of CVD. High systolic blood pressure (BP) was strongly related to intracerebral haemorrhage, subarachnoid haemorrhage, stable angina, myocardial infarction, and peripheral arterial disease (PAD). On the other hand, high diastolic BP had a stronger relationship with abdominal aortic aneurysm and pulse pressure had a stronger association with PAD and an inverse association with abdominal aortic aneurysm. Unstable angina was related to loss of life in younger ages, whereas heart failure and stable angina pectoris were related to years of life lost in the elderly. Thus, specific elements of BP were linked to specific manifestations of CVD and causes of death by CVD. Another recent study analysed the independent effects of 67 all-disease risk factors in 21 regions worldwide in 2010 and compared them with those of 1990. Hypertension immerged as the first cause of all-cause disease burden (7%), while in 1990 it was not included in the first 3 causes. A shift from communicable diseases of the children to the non-communicable diseases of the adults was also recorded in this 20-year period. A plethora of data suggests the hypertension is the number one killer both in Western World and Worldwide. The adoption of lifetime CVD risk estimates combined with efforts for increased awareness, education, and BP control will probably improve outcomes and substantially reduce CVD mortality.

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Polygalacto-fucopyranose from marine alga as a prospective antihypertensive lead

Surabhi

Dhara

Maneesh

et al. 2021

International Journal of Biological Macromolecules

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Focus on blood pressure as a major risk factor

Cited by 9 publications

References 12 publications

Antihypertensive Effects of Roselle‐Olive Combination in L‐NAME‐Induced Hypertensive Rats

Antihypertensive Effects of Roselle‐Olive Combination in L‐NAME‐Induced Hypertensive Rats

EDITORIAL-Blood Pressure as a Risk Factor of Global Disease Burden and its Association with Lifetime Risks of Different Manifestations of Cardiovascular Disease

Polygalacto-fucopyranose from marine alga as a prospective antihypertensive lead

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