Focally enhanced gastritis in children with Crohn's disease and ulcerative colitis

Abstract

The presence of FEG suggests underlying IBD. Although FEG is particularly common in children with Crohn's disease, it does not reliably differentiate between Crohn's disease and ulcerative colitis.

Ulcerative colitis with gastric and duodenal involvement

“…Both chronic active gastritis and duodenitis without HP infection are more frequent in Crohn's disease than in colitis, with a prevalence of diffuse gastritis of 28.6% and 40% (4), focally enhanced gastritis of 65.1% and 20.8% (4,5), and duodenitis 28% and 8%, respectively (3).…”

Gastroduodenitis associated with ulcerative colitis

“…However, in pediatric patients, not only case reports 7 but also a few case series have been published. [8][9][10][11] A high prevalence of histological gastritis was found in 50%-94% of pediatric patients with UC. [8][9][10][11] In a controlled study, duodenitis was more common in pediatric patients with UC (23%) than in control patients (9%).…”

“…[8][9][10][11] A high prevalence of histological gastritis was found in 50%-94% of pediatric patients with UC. [8][9][10][11] In a controlled study, duodenitis was more common in pediatric patients with UC (23%) than in control patients (9%). 8 These reports have cast doubt on whether upper GI involvement of UC is an unusual complication, although so-called indeterminate colitis (IC) shows a higher proportion in pediatric IBD than in adults.…”

“…Since Crohn's disease (CD), another IBD, can affect any portion of the digestive tract, the difference in distribution is one of the most common methods of discriminating between UC and CD; however, several cases of UC with upper gastrointestinal (GI) involvement have been reported recently. [1][2][3][4][5][6][7][8][9][10][11] The majority of such patients have duodenitis resembling UC both macroscopically and microscopically. [1][2][3] Greater spreading infl ammation such as gastroduodenitis or enteritis was also reported.…”

Pathology of non-Helicobacter pylori gastritis: extending the histopathologic horizons

“…13). First hailed as a specific feature of Crohn's disease, in which the prevalence of FEG ranges from 43 to 76% [82], it has been noted since in up to 21% of patients with ulcerative colitis [83]. Furthermore, FEG also can be diagnosed in bone marrow transplant patients [82], H. pylori gastritis (*3%), and reactive gastropathy [82].…”