Focal nodular hyperplasia coexistent with hemangioma and multiple cysts of the liver

Toshikuni, Nobuyuki; Kawaguchi, Kenji; Miki, Hiroshi; Kihara, Yasuhiro; Sawayama, Tomoyuki; Yamasaki, Satoshi; Takano, Satoshi; Minato, Takeshi

doi:10.1007/s005350170131

Cited by 11 publications

(7 citation statements)

References 19 publications

(18 reference statements)

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“…1-3 FNH is typically an incidental discovery during diagnostic imaging performed for other reasons. 3,4 Although considered a rare a b Fig. 6.…”

Section: Discussionmentioning

confidence: 98%

“…The pathogenesis and natural history of FNH remain largely unknown. [1][2][3][4][5][6][7][8][9] The role of endogenous estrogens has been suggested because of the female predominance and peak incidence during childbearing years. 1,2 Concerning exogenous estrogens, high-dose estrogens may be associated with enhanced growth and marked vascular changes in FNH lesions, resulting in the recommendation that high-dose OCs be discontinued in patients with FNH.…”

Section: Discussionmentioning

confidence: 99%

“…A localized increase in arterial blood flow produced by a vascular abnormality may be involved in the pathogenesis of FNH. [1][2][3] The natural history of FNH is still unknown, because long-term follow-up studies of histologically proven FNH have Microphotograph of the liver biopsy specimen. Hepatocytes were almost normal, but the radial arrangement of liver cell trabecula and lobular architecture is not observed.…”

Section: Introductionmentioning

confidence: 99%

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Spontaneous regression of focal nodular hyperplasia of the liver

Ohmoto

Honda

Hirokawa

et al. 2002

Journal of Gastroenterology

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Focal nodular hyperplasia (FNH) of the liver is a rare benign lesion that probably reflects a local hyperplastic response of hepatocytes to a vascular abnormality. Currently, the natural history of the disease remains largely unknown. We present a patient with FNH of the liver who was followed up for 4 years. A 22-year-old woman with a 3-year history of oral contraceptive use was referred to our hospital in September 1996 for further examination of a liver tumor. A diagnosis of FNH was made using various imaging methods, such as ultrasonography, enhanced computed tomography (CT) scanning, MR imaging, and hepatic angiography, as well as fine-needle biopsy. A decrease in the size of the lesion was observed by enhanced CT scanning during the 4-year observation period. In this patient, oral contraceptive use and its discontinuation may have influenced the natural history of FNH. The present case suggests that an accurate diagnosis is of the utmost importance, and a patient with FNH should be managed conservatively rather than by resection, because FNH has the potential for spontaneous regression with the discontinuation of oral contraceptives.

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“…1-3 FNH is typically an incidental discovery during diagnostic imaging performed for other reasons. 3,4 Although considered a rare a b Fig. 6.…”

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Spontaneous regression of focal nodular hyperplasia of the liver

Ohmoto

Honda

Hirokawa

et al. 2002

Journal of Gastroenterology

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“…Further published associations comprise FNH with hemangioma (Mathieu et al 1989;Wanless 2000;Vilgrain et al 2003), hemangioma and multiple liver cysts (Toshikuni et al 2001), hepatic adenoma and hemangioma (Di Carlo et al 2003), and angiomyolipoma, bile duct adenoma, and hemangioma (Langner et al 2001). FNH occurring with hemangioma of the liver is of particular practical and theoretical interest.…”

Section: Fnh and Hepatic Vascular Tumorsmentioning

confidence: 99%

Focal Nodular Hyperplasia (FNH) of the Liver

Zimmermann¹

2016

Tumors and Tumor-Like Lesions of the Hepatobiliary Tract

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Focal nodular hyperplasia (FNH) of the liver is a reactive mass-forming regenerative hyperplastic response of hepatocytes, secondary to localized vascular and circulatory abnormalities. FNH has a predilection for young females and represents, after hemangioma, the second most common benign hepatic tumorous lesion of the liver in adults. Many FNH are asymptomatic and detected by chance, but a minority of FNH are associated with various symptoms mainly related to large size or atypical location. Most FNH are solitary lesions that are predominantly located in the right liver lobe. In a minority of patients, multiple lesions, sometimes exceeding 30, are present. Macroscopically, FNH are well-circumscribed nodular, yellowish to tan masses with a characteristic nodular texture, radiating septa, and a central stellate scar-like fibrotic structure. Part of the lesions protrude from the liver and can become pedunculated masses. The diameter of FNH may exceed 20 cm. Histologically, FNH is characterized by nodules that consist of normal-looking hepatocytes forming thin plates. These nodules are separated from each other by fibrous septa and interspersed portal tract-like structures. The latter lack interlobular bile ducts but contain ductular proliferations. The fibrous tissue areas contain abnormal thick-walled blood vessels.

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“…Although the coexistence of multiple benign liver tumors, such as focal nodular hyperplasia (FNH), adenomas and hemangiomas, is already described [16,17], the combination of them and especially of FNH with HCC is very rare [18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%