Focal liver disease: comparison of dynamic contrast-enhanced CT and T2-weighted fat-suppressed, FLASH, and dynamic gadolinium-enhanced MR imaging at 1.5 T.

Semelka, Richard C.; Shoenut, J P; Kroeker, M A; Greenberg, Howard M.; Simm, F C; Minuk, Gerald Y.; Kroeker, Randall; Micflikier, Allan B.

doi:10.1148/radiology.184.3.1324509

Cited by 169 publications

(66 citation statements)

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“…While dynamic contrast examination has become a component of routine abdominal scans, the contrast material used increases costs and carries the risk of side effects. Additionally, in some cases, distinguishing vascular metastasis from hemangioma is not possible even with dynamic examination 16 . DWI is a technique which can be used within the duration of a held breath with no necessity for contrast material, and it helps to distinguish the "benign-malignant" nature of many focal lesions.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic value of diffusion weighted MRI and ADC in differential diagnosis of cavernous hemangioma of the liver

et al. 2016

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Aims: To investigate the use of diffusion weighted magnetic resonance imaging (DWI) and the apparent diffusion coefficient (ADC) values in the diagnosis of hemangioma. Materials and methods:The study population consisted of 72 patients with liver masses larger than 1 cm (72 focal lesions). DWI examination with a b value of 600 s/mm 2 was carried out for all patients. After DWI examination, an ADC map was created and ADC values were measured for 72 liver masses and normal liver tissue (control group). The average ADC values of normal liver tissue and focal liver lesions, the "cut-off " ADC values, and the diagnostic sensitivity and specificity of the ADC map in diagnosing hemangioma, benign and malignant lesions were researched. Results: Of the 72 liver masses, 51 were benign and 21 were malignant. Benign lesions comprised 38 hemangiomas and 13 simple cysts. Malignant lesions comprised 9 hepatocellular carcinomas, and 12 metastases. The highest ADC values were measured for cysts (3.782±0.53×10-3 mm 2 /s) and hemangiomas (2.705±0.63×10 -3 mm 2 /s). The average ADC value of hemangiomas was significantly higher than malignant lesions and the normal control group (p<0.001). The average ADC value of cysts were significantly higher when compared to hemangiomas and normal control group (p<0.001). To distinguish hemangiomas from malignant liver lesions, the "cut-off " ADC value of 1.800×10-3 mm 2 /s had a sensitivity of 97.4% and a specificity of 90.9%. To distinguish hemangioma from normal liver parenchyma the "cut-off " value of 1.858×10 -3 mm 2 /s had a sensitivity of 97.4% and a specificity of 95.7%. To distinguish benign liver lesions from malignant liver lesions the "cut-off " value of 1.800×10-3 mm 2 /s had a sensitivity of 96.1% and a specificity of 90.0%. Conclusion: DWI and quantitative measurement of ADC values can be used in differential diagnosis of benign and malignant liver lesions and also in the diagnosis and differentiation of hemangiomas. When dynamic examination cannot distinguish cases with vascular metastasis and lesions from hemangioma, DWI and ADC values can be useful in the primary diagnosis and differential diagnosis. The technique does not require contrast material, so it can safely be used in patients with renal failure .

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Section: Discussionmentioning

confidence: 99%

Diagnostic value of diffusion weighted MRI and ADC in differential diagnosis of cavernous hemangioma of the liver

et al. 2016

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“…Although radiolabeled RBC scintigraphy is a reliable test for the diagnosis of hepatic cavernous he mangioma, it does not readily localize small lesions and has a significant false-positive rate [2,4]. It also provides limited information on disease conditions other than hemangioma, which often makes subsequent CT or MR im aging necessary [4,13,14].…”

Section: Discussionmentioning

confidence: 99%

“…On MR imaging,cavernous hemangiomais seen as a strong, light bulbâ€"like signal on heavily T2-weightedimages [4,16], and with the ad vantages of dynamic MR imaging (such as a highly concentrated contrast agent injected over a short time and fast image acquisition in the arterial dominant phase),the characteristic dynamic CT findings of hemangioma can be more clearly observed [5,13,14].…”

Section: Discussionmentioning

confidence: 99%

Hepatic cavernous hemangioma: sonographic patterns and speed of contrast enhancement on multiphase dynamic MR imaging.

Yu¹,

Kim²,

Kim³

et al. 1998

American Journal of Roentgenology

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KiWhangKim1Jae-ChunChang3 Byung-JuneJo1 Tae-HoonKim1 JongTaeLee2 HyungSikYoo2 OBJECTIVE. Our purposewas to investigatea correlationbetweenthe speedof contrast enhancement in patientswith hepaticcavernoushemangiomarevealedby dynamicMR imag ing and the internal echo pattern revealed by sonography.MATERIALS AND METHODS. Forty-five patients underwent multiphase IV con trast-enhanced dynamic MR imaging that revealed7 1 hepaticcavernoushemangiomasless than 4 cm in diameter; the MR findingswere comparedwith the sonographicfindings in these patients.On MR imaging, the hemangiomaswere classifiedas rapid-, intermediate-, and slow-enhancing. We classified sonographic features as hypoechoic, iso-or mixed echoic, and hyperechoic according to the relative echogenicity seen between lesions and the surrounding hepatic parenchyma. Sonographic patterns and MR imaging findings of in dividual lesions were then compared.RESULTS. Rapid-enhancinghemangiomasrevealedon dynamic MR imaging tendedto be hypoechoic on sonography (18/24, 75%; p = .0143), and lesions that were slow-enhancing on MR imaging tended to be hyperechoic (26/29, 90%; p < .0001). Hypoechoic lesions on sonography tended to be rapid-enhancing on dynamic MR imaging (18/18, 100%). Likewise, hyperechoic lesions on sonography tended to be slow-enhancing on MR imaging (26/33, 79%; p = .0009). CONCLUSION.In mostpatientswith hepaticcavernoushemangiomas, we found that the speedof contrast enhancementon multiphase dynamic MR imaging enabled us to predict the echo pattern in sonography and vice versa.

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“…Spin echo echo-planar imaging (SE-EPI) sequence with single shot breath holding tecnique is performed in DWI. With the development of paralel imaging techniques, imaging time has become shorter, quality of EPI sequence has increased and addition of DWI to routine abdominal imaging has become more effective and popular [4][5][6]. Recent studies have shown the efficacy of quantitative apparent coefficient diffusion (ADC) measurements in differential diagnosis of benign and malignant liver masses [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Diffusion-weighted MRI: In differential diagnosis of liver masses

Ergelen¹,

Şahin²,

Bal³

et al. 2017

MMJ

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Objectives: The purpose of our study was to determine apparent diffusion coefficients (ADCs) of focal liver lesions on the basis of respiratory triggered diffusion-weighted single-shot echo-planar MR imaging (DWI-SS-EPI) sequence and to evaluate whether ADC measurements can be used to characterize lesions. Results: Results were correlated with characteristic MRI findings, histopathologic data and follow-up imagings. The ADCs of different lesion types were compared and lesion differentiation using optimal thresholds for ADCs was evaluated. Mean ADCs (x10 -3 mm 2 /s) were 2.15, 1.57, 1.16, 1.08, 1.03 for cysts, hemangiomas, FNHs, metastases and HCCs, respectively. Mean ADCs differed significantly for all lesion types except metastases, HCCs and FNHs. Overall, 88.5% of lesions were correctly classified as benign or malignant using a treshold value of 1.20x10 -3 mm 2 /s. Conclusion:Measurements of the ADCs of focal liver lesions on the basis of a respiratory triggered DWI-SS-EPI sequence may constitute a useful supplementary method for lesion characterization.

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Focal liver disease: comparison of dynamic contrast-enhanced CT and T2-weighted fat-suppressed, FLASH, and dynamic gadolinium-enhanced MR imaging at 1.5 T.

Cited by 169 publications

References 0 publications

Diagnostic value of diffusion weighted MRI and ADC in differential diagnosis of cavernous hemangioma of the liver

Diagnostic value of diffusion weighted MRI and ADC in differential diagnosis of cavernous hemangioma of the liver

Hepatic cavernous hemangioma: sonographic patterns and speed of contrast enhancement on multiphase dynamic MR imaging.

Diffusion-weighted MRI: In differential diagnosis of liver masses

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