Focal corticothalamic sources during generalized absence seizures: A MEG study

Distinct cerebellar lobules process arousal, valence and their interaction in parallel following a temporal hierarchy

“…However, there is an increasing number of recent demonstrations reporting MEG sensitivity to relatively deep source activity such as thalamus (Papadelis et al, 2012;Tenney et al, 2013), amygdala (Cornwell et al, 2008;Styliadis et al, 2014), hippocampus (Riggs et al, 2009) and cerebellum Martin et al, 2006). In line with these findings, our previous phantom studies have shown the ability of MEG to detect and localize deep thalamic dipolar sources of weak high-frequency activity with an accuracy of 10-15 mm (Papadelis and Ioannides, 2007;Papadelis et al, 2009).…”

Temporal current-source of spikes suggests initial treatment failure in childhood absence epilepsy

“…A study using current-source analysis of EEG data showed that the frontopolar regions were typically associated with seizure onset and were the most activated cortical regions during propagation of seizures in five adult patients with absence epilepsy [4]. Studies using other modalities of functional imaging such as MEG or EEG/ fMRI have demonstrated similar results [6,7,29,30].…”

“…These findings suggest that the localization and area of the cortical generators in IGE may be indicators of drug responsiveness. A circuit interconnecting the cortex and the thalamus plays a critical role in absence seizures [7,27]. Furthermore, cortical activation may lead directly to thalamic activation [28,29].…”

Tapping the Brakes: Cellular and Synaptic Mechanisms that Regulate Thalamic Oscillations

“…Local enhancement and focal starting points of traditionally global oscillations suggest underlying differences between thalamocortical loops (Andrillon et al, 2011; Meeren et al, 2002; Tenney et al, 2013). In this context, we also ask whether nucleus-specific specializations may bias subcircuits within the thalamocortical loop toward hypersynchronization and global propagation of oscillations.…”