Focal Cortical Atrophy Syndromes

Black, Sandra E.

doi:10.1006/brcg.1996.0042

Cited by 63 publications

(38 citation statements)

References 131 publications

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“…It has mainly been studied in the context of focal injury caused by stroke but more recently has also been studied in neurodegenerative disorders causing focal cortical damage (Black 1996). Limb apraxia has been reported in various neurodegenerative disorders, such as Alzheimer's Disease (Ochipa et al 1992;Foundas et al 1999;Parakh et al 2004) and Primary Progressive Aphasia (Joshi et al 2003).…”

Section: Introductionmentioning

confidence: 99%

A Model-Based Approach to Understanding Apraxia in Corticobasal Syndrome

2008

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Limb apraxia is a neurological disorder of higher cognitive function characterized by an inability to perform purposeful skilled movements and not attributable to an elementary sensorimotor dysfunction or comprehension difficulty. Corticobasal Syndrome (CBS) is an akinetic rigid syndrome with asymmetric onset and progression with at least one basal ganglia feature (rigidity, limb dystonia or myoclonus) and one cortical feature (limb apraxia, alien hand syndrome or cortical sensory loss). Even though limb apraxia is highly prevalent in CBS (70-80%), very few studies have examined the performance of CBS patients on praxis measures in detail. This review aims to (1) briefly summarize the clinical, neuroanatomical and pathological findings in CBS, (2) briefly outline what limb apraxia is and how it is assessed, (3) to comprehensively review the literature on limb apraxia in CBS to date and (4) to briefly summarize the literature on other forms of apraxia, such as limb-kinetic apraxia and buccofacial apraxia. Overall, the goal of the review is to bring a model-based perspective to the findings available in the literature to date on limb apraxia in CBS.

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Section: Introductionmentioning

confidence: 99%

A Model-Based Approach to Understanding Apraxia in Corticobasal Syndrome

2008

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“…Results from structural imaging in svPPA reveal atrophy in the perisylvian region (Abe et al, 1997;Sinnathamby et al, 1996), with a gradual extension towards posterior brain regions (Black, 1996;Price & Friston, 2001). Patients presenting with svPPA show left or bilateral temporal atrophy with widening of the Sylvian fissure but otherwise mostly normal imaging, with occasional temporoparietal hypoperfusion.…”

Section: Neuroimaging In Svppamentioning

confidence: 99%

Behavioural and neuroimaging changes after naming therapy for semantic variant primary progressive aphasia

et al. 2016

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“…However, atypical cases of Alzheimer's disease can present with "focal" syndromes of aphasia or frontal lobe executive dysfunction [7,8,29]. The subject of "focal" versus more generalized patterns of dementia dates back to Pick's original discussion [1] but has also been echoed in recent years [30].…”

Section: Clinical Featuresmentioning

confidence: 99%

Frontotemporal Dementia and Primary Progressive Aphasia: An Update

Kirshner

2010

Curr Neurol Neurosci Rep

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Frontotemporal dementias are syndromes of progressive dysfunction of the frontal and/or temporal lobes, either unilaterally or bilaterally. These syndromes were described clinically under the terms "primary progressive aphasia" in the United States and "frontotemporal dementia" in Europe and the United Kingdom. They are diagnosed by the clinical features of a frontal lobe neurobehavioral syndrome, or a language and cognitive deterioration. In recent years, molecular genetic findings in these syndromes, especially the tau and progranulin mutations on chromosome 17, have provided a molecular and genetic foundation for the understanding of frontotemporal dementia. These disorders are distinct from Alzheimer's disease but have some overlap with the syndrome of corticobasal degeneration, and with motor neuron disease. Treatments remain very limited, mainly involving therapy for the mood and behavioral symptoms, but advances in the molecular and genetic understanding of these conditions will hopefully lead to more specific therapies in the future.

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Focal Cortical Atrophy Syndromes

Cited by 63 publications

References 131 publications

A Model-Based Approach to Understanding Apraxia in Corticobasal Syndrome

A Model-Based Approach to Understanding Apraxia in Corticobasal Syndrome

Behavioural and neuroimaging changes after naming therapy for semantic variant primary progressive aphasia

Frontotemporal Dementia and Primary Progressive Aphasia: An Update

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