FNA diagnosis of osteoclast-like giant cell tumor of the pancreas

Sivanandham, Shanthakumari; Subashchandrabose, Priya; Muthusamy, Rajeshwari K

doi:10.4103/0970-9371.103951

Cited by 4 publications

(3 citation statements)

References 8 publications

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“…Previous studies have suggested that OGTP most commonly manifests without any specific sex-bias in individuals between 60 and 70 years of age, although in some cases it has been reported in individuals as young as 32 years old or as old as 82 years [ 16 , 25 ]. We observed OGTP to be the most common in individuals between 50 and 70 years old (range: 35–90 years), consistent with previous studies, although unlike this previous report we observed a significantly higher rate of OGTP among females (70.2% versus 48.7%, P =0.003).…”

Section: Discussionmentioning

confidence: 99%

“…On imaging, OGTP usually presents as a large cystic tumor with variable areas of hemorrhage and necrosis [ 20 , 25 ]. Hence, pancreatic cystic lesions such as pancreatic cystic tumors, pancreatic pseudocysts, and solid pancreatic tumors must be considered in the differential diagnosis with this tumor type [ 25 , 26 ]. However, a definitive diagnosis can only be established based upon histopathology or cytology.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Clinical Characteristics and Prognosis of Osteoclast-like Giant Cell Tumors of the Pancreas Compared with Pancreatic Adenocarcinomas: A Population-Based Study

Chen²,

Wang

et al. 2020

Med Sci Monit

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Background The incidence of osteoclast-like giant cell tumor of the pancreas (OGTP) is very low, and relatively little OGTP clinical data is available. The present study, therefore, sought to conduct a more comprehensive analysis of the clinical characteristics and prognosis of OGTP. Material/Methods A large population-based cohort analysis was conducted using the Surveillance, Epidemiology and End Results (SEER) registry. We conducted a systematic assessment of the demographic and clinical characteristics of these patients, in addition to assessing available prognostic and therapeutic data corresponding to their disease. We further compared overall survival (OS) in these OGTP and pancreatic adenocarcinoma (PA) patient cohorts, adjusting for sex, grade, stage, and surgical treatment by propensity score matching (PSM). Results We included a total of 47 OGTP patients and 73 150 PA patients in the present analysis. The mean ages of PA and OGTP diagnosis were 68.0 and 62.8 years, respectively. Compared with PA patients, OGTP patients were more likely to be female (70.2% versus 48.7%, P <0.01), to have early-stage disease, to have lower rates of lymph node metastasis (17.0% versus 28.8%, P <0.01) and distant metastasis (17.0% versus 45.1%, P <0.01), and to have higher rates of tumor resection (70.2% versus 15.4%, P <0.01). OGTP patients also had a significantly longer median OS than did PA patients (13 months versus 6 months; hazard ratio [HR] 0.55, 95% confidence interval [CI] 0.37–0.57, P <0.0001). No significant differences in tumor site preferences were detected. Our findings also suggested that being female, having early-stage disease, and undergoing surgical resection may be associated with a more favorable prognosis in patients with OGTP. Conclusions OGTP patients had distinctive clinical characteristics and a better prognosis compared with PA patients. Understanding these differences will help clinicians accurately recognize these diseases. Radical resection was beneficial to the survival of OGTP patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Clinical Characteristics and Prognosis of Osteoclast-like Giant Cell Tumors of the Pancreas Compared with Pancreatic Adenocarcinomas: A Population-Based Study

Chen²,

Wang

et al. 2020

Med Sci Monit

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“…Undifferentiated carcinoma with osteoclast-like giant cells (UCWOGC) is a rare abdominal tumor that is estimated to account for 1% of pancreatic tumors. 1 , 2 Although this cytologic variant has been identified in other tissues such as the skin, thyroid gland, ovary, and breast, 3 it has been most commonly reported in the pancreas and was first described by Rosai in 1968. 1 , 4 The tumor is often found on imaging and typically appears as a large heterogeneous mass with well-demarcated hyper- and hypoechoic areas that represent necrotic areas and cystic structures, respectively.…”

Section: Introductionmentioning

confidence: 99%

Undifferentiated Carcinoma with Osteoclast-Like Giant Cells of the Pancreas in a Patient with New Diagnosis of Follicular Non-Hodgkin's Lymphoma

Shah¹,

Khurana²,

Freid³

et al. 2014

ACG Case Reports Journal

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Pancreatic tumors with osteoclast-like giant cells are rare, with only 50 cases published to date. We report a case of a 67-year-old male with a new diagnosis of follicular non-Hodgkin's lymphoma with an incidental pancreatic body mass on abdominal imaging. Cytology from the pancreatic mass obtained via endoscopic ultrasound-directed fine-needle aspiration (EUS-FNA) revealed an undifferentiated carcinoma with osteoclast-like giant cells.

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Undifferentiated carcinoma with osteoclast‐like giant cells of pancreas on cytology: A case report with review of literature

Gupta¹,

Goyal²,

Chaudhary³

et al. 2022

Diagnostic Cytopathology

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Undifferentiated carcinoma with osteoclast‐like giant cells (UC‐OGC) is a rare malignant neoplasm accounting for <1% of pancreatic masses. Very few case reports and small series have described the cytomorphological features of this entity. We report a case of UC‐OGC arising in the pancreas presenting with liver metastasis in a 56‐year‐old man diagnosed by guided fine‐needle aspiration cytology (FNAC). A characteristic biphasic pattern comprising of malignant mononuclear cells with scattered bland giant cells were the hallmark features for cytological diagnosis. Our case along with review of cytology literature emphasize the utility of FNAC and the cell block in the diagnosis and management of this rare entity.

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FNA diagnosis of osteoclast-like giant cell tumor of the pancreas

Cited by 4 publications

References 8 publications

Clinical Characteristics and Prognosis of Osteoclast-like Giant Cell Tumors of the Pancreas Compared with Pancreatic Adenocarcinomas: A Population-Based Study

Clinical Characteristics and Prognosis of Osteoclast-like Giant Cell Tumors of the Pancreas Compared with Pancreatic Adenocarcinomas: A Population-Based Study

Undifferentiated Carcinoma with Osteoclast-Like Giant Cells of the Pancreas in a Patient with New Diagnosis of Follicular Non-Hodgkin's Lymphoma

Undifferentiated carcinoma with osteoclast‐like giant cells of pancreas on cytology: A case report with review of literature

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