Undifferentiated Carcinoma with Osteoclast-Like Giant Cells of the Pancreas in a Patient with New Diagnosis of Follicular Non-Hodgkin's Lymphoma

Shah, Apeksha; Khurana, Tanvi; Freid, Lauren; Siddiqui, Ali A.

doi:10.14309/crj.2014.17

Cited by 5 publications

(4 citation statements)

References 9 publications

(12 reference statements)

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“…8,[21][22][23] Although the histologic features of UOC (aka, "osteoclastic giant cell carcinoma") are well known, its cytologic features are described only rarely and mostly in isolated reports or small series. 12,[24][25][26][27][28][29][30][31][32][33][34][35][36][37][38] Herein, we present the cytologic findings in 15 fine-needle aspirations (FNAs) defined by the presence of OGCs and highlight useful diagnostic cytologic characteristics as well as pertinent clinicopathologic features and associations. To date, this is the largest cytologic series in the English literature.…”

Section: Introductionmentioning

confidence: 99%

Cytologic features and clinical implications of undifferentiated carcinoma with osteoclastic giant cells of the pancreas: An analysis of 15 cases

Reid

Muraki

HooKim

et al. 2017

Cancer Cytopathology

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Section: Introductionmentioning

confidence: 99%

Cytologic features and clinical implications of undifferentiated carcinoma with osteoclastic giant cells of the pancreas: An analysis of 15 cases

Reid

Muraki

HooKim

et al. 2017

Cancer Cytopathology

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“…Tumor compression of the pancreatic duct may cause pancreatitis 22 or dilation of the pancreatic duct, 23 and there may be complaints of discomfort due to elevated tumor markers 24 or incidental detection of other diseases during examination. 25,26 The preoperative diagnosis of UCOGCP mainly depends on CT and MRI. PETCT can provide useful information about the metabolic status of the tumor and the presence or absence of distant metastasis.…”

Section: Discussionmentioning

confidence: 99%

Undifferentiated Carcinoma of Pancreas with Osteoclast-Like Giant Cells: One Center’s Experience of 13 Cases and Characteristic Pre-Operative Images

Gao¹,

Cai²,

Yin³

et al. 2022

CMAR

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Background: Undifferentiated carcinoma of pancreas with osteoclast-like giant cells is an extremely rare tumor in pancreas. It is relatively difficult to have preoperative diagnosis due to the lack of specific tumor markers and pre-operative images. Methods: In the present study, database of the pancreas center in the First Affiliated Hospital of Nanjing Medical University was retrospectively screened. A total of thirteen cases diagnosed as undifferentiated carcinoma of pancreas with osteoclast-like giant cells were included. Their clinical data and treatments were collected. Results: Thirteen patients include eight males and five females, and the median age was 67 (60-72) years old. The lesions were found in more than half patients through health examination with no symptoms. NSE was elevated in eight cases (66%). CT scan revealed that cystic and solid lesions often had thick (4/5), contrast-enhanced (5/5) wall with smooth edges (5/5) and the boundary of lesions mainly with solid composition (4/10) is not well demarcated with normal pancreatic parenchyma. All patients received surgical resection. Eight patients had adjuvant chemotherapy and only one patient had adjuvant radiotherapy. The median survival time was 13 months. Five patients had postoperative metastasis or recurrence of tumor and four of them had died of this disease during follow-up. Conclusion: Our data showed that elevated level of NSE and characteristic pre-operative images might provide aid with the preoperative diagnosis for undifferentiated carcinoma of pancreas with osteoclast-like giant cells. Patients with suspected diagnosis should receive surgical intervention as soon as possible, supplemented with postoperative chemotherapy, in order to prolong the survival of patients.

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“…Despite its rapid growth and large tumor size, the biological behavior of UCOGCP is different from that of common PDAC ( 77 ). Although UCOGCP grows rapidly, recent reports suggest that perineural invasion and lymph node metastasis are rare, and its prognosis is relatively better than that of PDAC and pleomorphic giant cell tumor ( 32 , 78 ). According to Muraki’s study, the five-year survival rate of resected UCOGCP is 59.1%, while the five-year survival rate of resected PDAC is 15.7% ( 32 ).…”

Section: Prognosismentioning

confidence: 99%

Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas: a narrative review

2024

Front. Oncol.

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Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas (UCOGCP) is a rare pancreatic tumor that accounts for less than 1% of all pancreatic malignancies. The characteristic pathological manifestation of UCOGCP is the presence of osteoclast-like giant cells (OGCs) distributed among pleomorphic undifferentiated tumor cells. UCOGCP can occur either alone or in association with other types of pancreatic tumors. At present, there is no unified consensus or guideline for the diagnosis and treatment of UCOGCP, and most of the literature are individual case reports. With the accumulation in the number of clinical cases and the development of precision medicine technology, the understanding of UCOGCP is also deepening. Researchers have begun to recognize that UCOGCP is a pancreatic tumor with distinctive clinical and molecular characteristics. In this review, we focus on the latest research status and future exploration directions in the diagnosis, treatment, and prognosis of UCOGCP.

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Undifferentiated Carcinoma with Osteoclast-Like Giant Cells of the Pancreas in a Patient with New Diagnosis of Follicular Non-Hodgkin's Lymphoma

Cited by 5 publications

References 9 publications

Cytologic features and clinical implications of undifferentiated carcinoma with osteoclastic giant cells of the pancreas: An analysis of 15 cases

Cytologic features and clinical implications of undifferentiated carcinoma with osteoclastic giant cells of the pancreas: An analysis of 15 cases

Undifferentiated Carcinoma of Pancreas with Osteoclast-Like Giant Cells: One Center’s Experience of 13 Cases and Characteristic Pre-Operative Images

Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas: a narrative review

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