fMRI Evidence for Separable and Lateralized Prefrontal Memory Monitoring Processes

Dobbins, Ian G.; Simons, Jon S.; Schacter, Daniel L.

doi:10.1162/0898929041502751

Cited by 91 publications

(79 citation statements)

References 43 publications

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“…Given that there were several cognitive control processes that were not directly manipulated in the current experiment, it is possible that right DLPFC activity in this study may be related to any of these control processes. However, our current results are consistent with previous studies implicating right DLPFC in monitoring processes engaged during familiarity-related retrieval processing (Dobbins, Simons, & Schacter, 2004;Dudukovic & Wagner, 2007;Henson, Rugg, Shallice, & Dolan, 2000;Petrides, 2000b) …”

Section: Retrieval-related Activity In Right Dlpfcsupporting

confidence: 93%

“…It has been argued that increased right DLPFC activity during both EM and WM recency tasks reflects the role of this region in familiarity-based retrieval monitoring (Dobbins, Rice, Wagner, & Schacter, 2003;Dobbins, Simons, & Schacter, 2004;Mitchell, Johnson, Raye, & Greene, 2004;Yonelinas, Otten, Shaw, & Rugg, 2005). According to this perspective recognition and temporal context retrieval tasks can be performed by making judgments about the relative feelings-of-familiarity of retrieved stimuli, wherein more recent stimuli are inherently more salient and thus more familiar.…”

Section: Retrieval-related Activity In Right Dlpfcmentioning

confidence: 99%

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Prefrontal contributions to domain-general executive control processes during temporal context retrieval

2008

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Neuroimaging studies have reported increased prefrontal cortex (PFC) activity during temporal context retrieval versus recognition memory. However, it remains unclear if these activations reflect PFC contributions to domain-general executive control processes or domain-specific retrieval processes. To gain a better understanding of the functional roles of these various PFC regions during temporal context retrieval we propose it is necessary to examine PFC activity across tasks from different domains, in which parallel manipulations are included targeting specific cognitive processes. In the current fMRI study, we examined domain-general and domain-specific PFC contributions to temporal context retrieval by increasing stimulus (but maintaining response number) and increasing response number (but maintaining stimulus number) across temporal context memory and ordering control tasks, for faces. The control task required subjects to order faces from youngest to oldest. Our behavioral results indicate that the combination of increased stimulus and response numbers significantly increased task difficulty for temporal context retrieval and ordering tasks. Across domains, increasing stimulus number, while maintaining response numbers, caused greater right lateral premotor cortex (BA 6/8) activity; whereas increasing response number, while maintaining stimulus number, caused greater domain-general left DLPFC (BA 9) and VLPFC (BA 44/45) activity. In addition, we found domain-specific right DLPFC (BA 9) activity only during retrieval events. These results highlight the functional heterogeneity of frontal cortex, and suggest its involvement in temporal context retrieval is related to its role in various cognitive control processes.

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Section: Retrieval-related Activity In Right Dlpfcsupporting

confidence: 93%

Section: Retrieval-related Activity In Right Dlpfcmentioning

confidence: 99%

Prefrontal contributions to domain-general executive control processes during temporal context retrieval

2008

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“…Recent findings from neuroimaging studies have supported the idea that the left and right PFC may contribute differently to recollection and familiarity processes (Nolde et al, 1998;Cabeza et al, 2003;Kensinger et al, 2003;Dobbins et al, 2004;Mitchell et al, 2004) (for review, see Ranganath, 2004). For example, some researchers have suggested that the left PFC might disproportionately contribute to recollection of specific information (Nolde et al, 1998;Kensinger et al, 2003;Dobbins et al, 2004;Mitchell et al, 2004).…”

Section: Discussionmentioning

confidence: 96%

“…Because stimulus presentation was lateralized during encoding, we were able to assess memory performance separately for objects processed preferentially by the lesioned versus the spared hemisphere. In addition, prompted by neuroimaging evidence suggesting that there may be some laterality differences within the PFC in regard to recollection and familiarity (Nolde et al, 1998;Kensinger et al, 2003;Dobbins et al, 2004;Mitchell et al, 2004), we characterized the effects of left versus right frontal lesions.…”

Section: Introductionmentioning

confidence: 99%

Effects of Unilateral Prefrontal Lesions on Familiarity, Recollection, and Source Memory

Duarte¹,

Ranganath²,

Knight³

2005

J. Neurosci.

130

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Recognition memory can be supported by both the assessment of the familiarity of an item and by recollection of the context in which an item was encountered. Some have hypothesized that the prefrontal cortex (PFC) disproportionately contributes to recollection, whereas an alternative view is that the PFC contributes to both recollection and familiarity. Here, we examined the effects of prefrontal lesions on recollection and familiarity. Patients with unilateral PFC lesions and age-, gender-, and education-matched controls encoded pictures of meaningful objects that were presented briefly to the left or right visual field and subsequently performed recognition tests for centrally presented objects. Laterality effects within the PFC were also assessed in relation to recollection and familiarity processes. Patients with prefrontal lesions showed impaired familiarity-based recognition, and this deficit was specific for objects encoded by the lesioned hemisphere. In addition, recollection of the context in which each item was encountered was impaired independent of the visual field of presentation in patients with left prefrontal lesions. Recollection measured by subjective reports ("remember") was not impaired in either left or right frontal patients. These findings suggest that the PFC plays a critical role in recognition memory based on familiarity as well as recollection. Furthermore, these results suggest that left PFC regions are critical for source recollection.

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“…Accordingly, it is thought to play a critical role in the storage and/or recollection of contextual associations (43). In contrast, activation specifically of right-lateralized frontal and parietal regions has been associated with controlled memory retrieval (44) and heuristic evaluation processes (45), the monitoring of retrieved memoranda (46), and more general retrieval-related decision-making (47). Together, these findings indicate that the DMN supports rapid, effortless retrieval of contextual associations, whereas the RFPN may support more strategic searches through memory and/or the monitoring of retrieved information.…”

Section: Discussionmentioning

confidence: 99%

Competitive and cooperative dynamics of large-scale brain functional networks supporting recollection

Fornito

Harrison

Zalesky

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

Self Cite

503

445

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Analyses of functional interactions between large-scale brain networks have identified two broad systems that operate in apparent competition or antagonism with each other. One system, termed the default mode network (DMN), is thought to support internally oriented processing. The other system acts as a generic external attention system (EAS) and mediates attention to exogenous stimuli. Reports that the DMN and EAS show anticorrelated activity across a range of experimental paradigms suggest that competition between these systems supports adaptive behavior. Here, we used functional MRI to characterize functional interactions between the DMN and different EAS components during performance of a recollection task known to coactivate regions of both networks. Using methods to isolate task-related, context-dependent changes in functional connectivity between these systems, we show that increased cooperation between the DMN and a specific right-lateralized frontoparietal component of the EAS is associated with more rapid memory recollection. We also show that these cooperative dynamics are facilitated by a dynamic reconfiguration of the functional architecture of the DMN into core and transitional modules, with the latter serving to enhance integration with frontoparietal regions. In particular, the right posterior cingulate cortex may act as a critical information-processing hub that provokes these context-dependent reconfigurations from an intrinsic or default state of antagonism. Our findings highlight the dynamic, contextdependent nature of large-scale brain dynamics and shed light on their contribution to individual differences in behavior.complex | graph | modularity | rest | connectome I ncreasing evidence points to a fundamental distinction between two large-scale functional systems in the brain (1-4). One system, comprising regions of lateral prefrontal and parietal cortex, dorsal anterior cingulate, and anterior insula/frontoopercular regions, typically shows increased activation during performance of challenging cognitive tasks and has been implicated in attentional and cognitive control functions (5, 6). It may thus be generally referred to as an external attention system (EAS), but it has also been labeled the task-positive and extrinsic network (3, 4). The other system, often called the default mode network (DMN), is localized primarily to midline posterior and anterior cortical regions, the angular gyri, and medial and lateral temporal cortices (7,8). It often shows decreased activity during tasks requiring attention to external stimuli (9, 10) and increased activity during unconstrained thought, introspection, and self-related processing (7, 11). The apparent antagonism between these two systems is mirrored in their spontaneous dynamics, which are often strongly anticorrelated (2). These competitive interactions are thought to promote adaptive and efficient alternation between DMN-dominated introspective thought and EAS-mediated processing of external stimuli (1-4).Several lines of evidence support thi...

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fMRI Evidence for Separable and Lateralized Prefrontal Memory Monitoring Processes

Cited by 91 publications

References 43 publications

Prefrontal contributions to domain-general executive control processes during temporal context retrieval

Prefrontal contributions to domain-general executive control processes during temporal context retrieval

Effects of Unilateral Prefrontal Lesions on Familiarity, Recollection, and Source Memory

Competitive and cooperative dynamics of large-scale brain functional networks supporting recollection

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