FMRFamide neuropeptides and neuropeptide-associated enzymes inDrosophila

Taghert, Paul H.

doi:10.1002/(sici)1097-0029(19990415)45:2<80::aid-jemt3>3.0.co;2-x

Cited by 62 publications

(41 citation statements)

References 68 publications

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“…The Drosophila FMRFamides have been reported to activate larval neuromuscular junctions and to inhibit heartbeat (3,38,40,41). At the larval neuromuscular junctions, all FMRFamides acted similarly (except for FMRFamide-7, which was inactive), suggesting that these peptides were functionally redundant (3,40).…”

Section: Discussionmentioning

confidence: 99%

“…Since then, FMRFamide and FMRFamide-related peptides have been isolated from a wide variety of invertebrate species, ranging from primitive metazoans, such as cnidarians, to higher invertebrates, such as insects (2)(3)(4)(5). FMRFamide-related peptides occur in all classes of cnidarians, suggesting that these peptides were among the first transmitters used in evolution (6).…”

mentioning

confidence: 99%

“…FMRFamide-related peptides may act excitatory or inhibitory on their target cells (depending on the target cell type) and they are involved in reproduction, feeding, and many other behaviors (3,5,(14)(15)(16)(17)(18). The abundance, complexity, and importance of FMRFamide peptides within an invertebrate species, is illustrated by the fact that the nematode worm Caenorhabditis elegans contains at least 20 FMRFamide preprohormone genes, and that the deletion of only one of these genes causes severe behavioral defects (5,17,19).…”

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confidence: 99%

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Molecular cloning and functional expression of the first insect FMRFamide receptor

Cazzamali

Grimmelikhuijzen

2002

Proc. Natl. Acad. Sci. U.S.A.

115

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FMRFamide and FMRFamide-related neuropeptides are extremely widespread and abundant in invertebrates and have numerous important functions. Here, we have cloned a Drosophila orphan receptor, and stably expressed it in Chinese hamster ovary cells. Screening of a peptide library revealed that the receptor reacted with high affinity to FMRFamide (EC50, 6 ؋ 10 ؊9 M). The intrinsic Drosophila FMRFamide peptides are known to be synthesized as a large preprohormone, containing at least 13 related FMRFamide peptides (8 distinct FMRFamides). Screening of these intrinsic Drosophila FMRFamides showed that the receptor had highest affinity to Drosophila FMRFamide-6 (PDNFMRFamide) (EC50, 9 ؋ 10 ؊10 M), whereas it had a somewhat lower affinity to Drosophila FMRFamide-2 (DPKQDFMRFamide) (EC50, 3 ؋ 10 ؊9 M) and considerably less affinity to the other Drosophila FMRFamide-related peptides. To our knowledge, this article is the first report on the molecular identification of an invertebrate FMRFamide receptor.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Molecular cloning and functional expression of the first insect FMRFamide receptor

Cazzamali

Grimmelikhuijzen

2002

Proc. Natl. Acad. Sci. U.S.A.

115

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“…13) In all the invertebrates they evoke muscle contraction whereas in the vertebrates they act on the opioid systems. 75,76) The FMRFamide and _ FMRF _ amide-_ related _ peptides are collectively referred to as FaRPs. Insect FaRPs fall under 5 families that can be traced to 5 genes in Drosophila.…”

Section: Fmrfamides and Fmrfamide-related Peptides (Farps)mentioning

confidence: 99%

“…In insects they can inhibit contractions in the fore-, mid-, and hindgut, as well as the oviduct, inhibit writhing of Malpighian tubules, inhibit the release of AKH, and potentiate contraction in a few locust skeletal muscles. 76) In the crayfish, P. clarkii, DRNFLRFamide is released from the pericardial organs and thought to function as a neurohormone. 88) It increases the amplitude of excitatory junction potentials (EJPs) in deep extensor muscles (DEMs) involving a presynaptic mechanism requiring calcium/calmodulin-dependent protein kinase, protein kinase C and cyclic nucleotide dependent protein kinases.…”

Section: Fmrfamides and Fmrfamide-related Peptides (Farps)mentioning

confidence: 99%

Molecular physiology of crustacean and insect neuropeptides

Mercier¹,

Doucet

Retnakaran³

2007

J. Pestic. Sci.

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One of the principal hallmarks of a living organism is its ability to respond to stimuli. As the unicellular organisms evolved into multicellular metazoans, the external signals perceived had to be transduced to several other cells requiring a neuronal network with its accompanying biochemical neurotransmitters. The progressive increase in complexity of the organisms necessitated the need for an integrated signal transducing system collecting external sensory stimuli and sending them to effector systems such that a dynamic equilibrium or homeostasis, which is essential for survival, could be maintained. During the course of evolution many advanced sense organs were developed to detect various parameters in the environment, and concomitantly different internal effector systems were formed to respond to these signals received from outside to maintain homeostasis. Coordination was achieved with a network of electrical conductors in the form of an arborized nervous system and a variety of hydrophilic biochemicals that acted as neurotransmitters carrying the sensory signals to the internal effector systems. As the animal became increasingly complex, a sophisticated neurotransmission system catering to the spatial and temporal needs during growth, development and reproduction had to be in place. Parts of the nervous tissue in many locations took on a secretory role and released protein signal transducers, the neuropeptides. A panoply of such neuropeptides exist in all organisms functioning as neurohormones, neurotransmitters or neuromodulators. Aspects of neuropeptide structure and function in insects and crustaceans have been reviewed by various authors. [1][2][3][4][5][6][7][8][9][10] The neuropeptides are ligands to their cognate receptors in the ef- Organisms have to constantly respond to environmental conditions to maintain a status of dynamic homeostasis for survival. As single celled organisms evolved into multicellular animals, intercellular and inter-organ communications became indispensable not only to orchestrate homeostasis but also to control the many events punctuating metazoan development. To accomplish this need, a signal transduction system was evolved, consisting of an arborized network of nerves as well as a collection of oligopeptide neurotransmitters (neuropeptides) along with their cognate receptors. We review here the current state of our understanding of the physiology of neuropeptides in the most species-rich group of animals, the crustaceans and insects. The vast majority of neuropeptides signal through cell-surface guanosine-protein coupled receptors (GPCRs). These neuropeptide-receptor systems control a variety of physiological functions, for instance the numerous involuntary movements of internal ducts that are precisely timed for transporting reproductive, digestive and secretory materials. The rigid exoskeleton in Crustaceans and Insects require periodic molts to accomplish growth and metamorphosis and this is harmoniously regulated by a cascade of neuropeptides. Neuropeptides also regul...

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Tagma-specific distribution of FXPRLamides in the nervous system of the American cockroach

Predel

Eckert

2000

J. Comp. Neurol.

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FMRFamide neuropeptides and neuropeptide-associated enzymes inDrosophila

Cited by 62 publications

References 68 publications

Molecular cloning and functional expression of the first insect FMRFamide receptor

Molecular cloning and functional expression of the first insect FMRFamide receptor

Molecular physiology of crustacean and insect neuropeptides

Tagma-specific distribution of FXPRLamides in the nervous system of the American cockroach

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