FMH-induced decrease in central histamine levels produces increased feeding and body weight in rats

Orthen-Gambill, Nilla; Salomon, Melinda

doi:10.1016/0031-9384(92)90132-l

Cited by 45 publications

(17 citation statements)

References 14 publications

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“…Intracerebroventricular administration of this compound significantly increases food intake in rats. [16][17][18][19] Together, these findings provide consistent evidence for histamine being an anorexigenic agent.…”

Section: Introductionsupporting

confidence: 59%

Effect of histaminergic manipulation on weight in obese adults: a randomized placebo controlled trial

Barak¹,

Greenway

Fujioka

et al. 2008

Int J Obes

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Objective: To determine the magnitude and determinants of weight loss in humans exposed to betahistine, a centrally acting histamine-1 (H-1) agonist and partial histamine-3 (H-3) antagonist. Design: A multicenter randomized, placebo-controlled dose-ranging weight loss trial with a 12-week treatment period. Subjects: Two hundred and eighty-one obese but otherwise healthy participants. Measurements: Weight and obesity-related comorbidities at baseline and at the end of the intervention. Results: Betahistine, at the doses tested, did not induce significant weight loss. With the exception of headache, no difference in adverse effect profile was noted between placebo and treatment groups. Subgroup analysis revealed that age below 50 years, ethnicity (non-Hispanics) and gender (women) were the strongest predictors of weight loss in this population. When these three factors were combined together, the betahistine 48 mg group (n ¼ 23) lost À4.24 ± 3.87 kg, whereas the placebo group (n ¼ 25) lost À1.65±2.96 kg during this time period (P ¼ 0.005). Conclusion: Betahistine, at the doses tested, induced significant weight loss with minimal adverse events only in women below 50 years.

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Section: Introductionsupporting

confidence: 59%

Effect of histaminergic manipulation on weight in obese adults: a randomized placebo controlled trial

Barak¹,

Greenway

Fujioka

et al. 2008

Int J Obes

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“…Therefore, according to the previous points of view from human studies, feeding suppression has seemed to be caused by alteration of zinc metabolism rather than direct effects of histidine. However, pretreat ment with alpha-fluoromethyl histidine (FMH), a spe cific suicide inhibitor of histamine-synthesizing histi dine decarboxylase (HDC), attenuated histidine-induced feeding suppression in animal studies (5,6). These results support the view that histidine-induced hista mine rather than the histidine-induced zinc deficiency affects food intake.…”

supporting

confidence: 77%

“…Recently, it has been hypothesized that L-histidine (histidine), an essential amino acid, might also control food intake through its conversion into histamine (4)(5)(6). Histidine preloads delivered by intraperitoneal injection (IP) into rats reduced food intake (7,8) and increased water intake (8,9).…”

mentioning

confidence: 99%

Histidine Intake May Negatively Correlate with Energy Intake in Human: A Cross-Sectional Study in Japanese Female Students Aged 18 Years

Okubo¹,

Sasaki²

2005

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummaryL-Histidine (histidine), a precursor of neuronal histamine, has recently been hypothesized to suppress food intake. The association between dietary histidine and energy intake was examined among 1,689 Japanese female students of dietetic courses aged 18y. Nutrient intakes were assessed over a 1-mo period with a validated, self-administered, diet history questionnaire. Both intake of histidine and the ratio of histidine to protein (histidine/ protein) statistically and positively correlated with energy intake. After adjustment for potential non-dietary confounding factors, including body height, body weight, physical activity level, and rate of eating, both the histidine intake and histidine/protein ratio statis tically and positively correlated with energy intake (Pearson's correlation coefficient, r=0.62 and 0.12, respectively, p<0.001). Moreover, when protein or protein excluding his tidine was additionally included into the covariates in order to minimize the effect of dietary factors and other amino acids, both histidine intake and histidinelprotein ratio turned out to show a statistically negative correlation with energy intake (r=-0.22 and -0.23, respectively, p<0.001). Considering the influence of unavoidable various covariates, we found an inverse association between histidinelprotein ratio and energy intake among the young female Japanese students.

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“…Ever since the establishment of the sedative actions of classical antihistamines, it has become clear that this neuronal mediating system, recognized initially for its allergic reactions, is involved in many vital brain functions such as pain, feeding, sleeping, and thermoregulation (Orthen-Gambill and Salomon, 1992;Sakata et al, 1997;Parmentier et al, 2002). The histaminergic neuronal fibers, originating from the hypothalamus, are projected extensively in the brain and promote their actions via three pharmacologically distinct receptor subtypes denoted as H n R (H 1-3 R) (Leurs et al, 2005).…”

mentioning

confidence: 99%

The Histaminergic Signaling System Exerts a Neuroprotective Role against Neurodegenerative-Induced Processes in the Hamster

Canonaco

Madeo²,

Alò³

et al. 2005

J Pharmacol Exp Ther

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The neurotoxic 3-nitropropionic acid (3-NP), a freckled milk vetch-derived inhibitor of mitochondrial enzymatic processes that is capable of mimicking the typical pathological features of neurodegenerative disorders, behaved in a differentiated manner in a hibernating rodent (hamster) with respect to a nonhibernating rodent (rat). Treatment of the two rodents with both an acute and chronic 3-NP dose supplied deleterious neuronal effects due to distinct histamine receptor (H n R) transcriptional activities, especially in the case of the rat. In hamsters, these treatment modalities accounted for overall reduced global activity in a freely moving environment and overt motor symptoms such as hindlimb dystonia and clasping with respect to the greater abnormal motor behaviors in rats. This behavioral difference appeared to be strongly related to qualitative fewer neuronal alterations and, namely, lesser crenated cell membranes, swollen mitochondria, and darkened nuclei in hamster brain areas. Moreover, a mixed H 1,3 R mRNA expression pattern was reported for both rodents treated with a chronic 3-NP dose as demonstrated by predominantly low H 1 R mRNA levels (Ͼ50%) in rat striatum and cortex, whereas extremely high H 3 R levels (Ͼ80%) characterized the lateral and central amygdala nuclei plus the striatum of hamsters. Interestingly, the H 3 R antagonist (thioperamide) blocked 3-NP-dependent behaviors plus induced an up-regulation of H 1 R levels in mainly the above-reported hamster amygdalar nuclei. Overall, these results show, for the first time, that a major protective role against neurodegenerative events appears to be strongly related to the expression activity of H 1,3 R subtypes of amygdalar neurons in this hibernating model.

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FMH-induced decrease in central histamine levels produces increased feeding and body weight in rats

Cited by 45 publications

References 14 publications

Effect of histaminergic manipulation on weight in obese adults: a randomized placebo controlled trial

Effect of histaminergic manipulation on weight in obese adults: a randomized placebo controlled trial

Histidine Intake May Negatively Correlate with Energy Intake in Human: A Cross-Sectional Study in Japanese Female Students Aged 18 Years

The Histaminergic Signaling System Exerts a Neuroprotective Role against Neurodegenerative-Induced Processes in the Hamster

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